1uud - Revision history

OCA at 07:49, 12 July 2023

OCA — Wed, 12 Jul 2023 07:49:49 GMT

←Older revision		Revision as of 07:49, 12 July 2023
Line 1:		Line 1:

	==NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA==		==NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA==
-	<StructureSection load='1uud' size='340' side='right'caption='[[1uud~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1uud' size='340' side='right'caption='[[1uud]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/HIV-1_M:B_HXB2R HIV-1 M:B_HXB2R]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UUD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[[~~1uts\|1uts]],~~ [~~[1uui\|1uui~~]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [https://pdbe.org/1uud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [https://www.ebi.ac.uk/pdbsum/1uud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [https://pdbe.org/1uud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [https://www.ebi.ac.uk/pdbsum/1uud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uud ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: HIV-1 M:B_HXB2R]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aboul-Ela, F]]	+	[[Category: Aboul-Ela F]]
-	[[Category: Afshar, M]]	+	[[Category: Afshar M]]
-	[[Category: Bower, J]]	+	[[Category: Bower J]]
-	[[Category: Davis, B]]	+	[[Category: Davis B]]
-	[[Category: Drysdale~~, M J~~]]	+	[[Category: Drysdale MJ]]
-	[[Category: Karn, J]]	+	[[Category: Karn J]]
-	[[Category: Lentzen, G]]	+	[[Category: Lentzen G]]
-	[[Category: Murchie~~, A I.H~~]]	+	[[Category: Murchie AIH]]
-	[[Category: Potter~~, A J~~]]	+	[[Category: Potter AJ]]
-	[[Category: Varani, G]]	+	[[Category: Varani G]]
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Ligand-rna interaction]]~~	+
-	~~[[Category: Rna bulge]]~~	+
-	~~[[Category: Tar rna~~]]	+

OCA at 06:18, 6 October 2021

OCA — Wed, 06 Oct 2021 06:18:12 GMT

←Older revision		Revision as of 06:18, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1uud' size='340' side='right'caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1uud' size='340' side='right'caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UUD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UUD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uts\|1uts]], [[1uui\|1uui]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uts\|1uts]], [[1uui\|1uui]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [~~http~~://pdbe.org/1uud PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uud PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uud ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [https://pdbe.org/1uud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [https://www.ebi.ac.uk/pdbsum/1uud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uud ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:22, 1 January 2020

OCA — Wed, 01 Jan 2020 13:22:21 GMT

←Older revision		Revision as of 13:22, 1 January 2020
Line 1:		Line 1:

	==NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA==		==NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA==
-	<StructureSection load='1uud' size='340' side='right' caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1uud' size='340' side='right'caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UUD FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aboul-Ela, F]]		[[Category: Aboul-Ela, F]]
	[[Category: Afshar, M]]		[[Category: Afshar, M]]

OCA at 08:11, 28 March 2018

OCA — Wed, 28 Mar 2018 08:11:04 GMT

←Older revision		Revision as of 08:11, 28 March 2018
Line 1:		Line 1:
-	==NMR ~~STRUCTURE OF A SYNTHETIC SMALL MOLECULE~~, ~~RBT203~~, ~~BOUND TO~~ HIV-1 TAR RNA==	+
		+	==NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA==
	<StructureSection load='1uud' size='340' side='right' caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1uud' size='340' side='right' caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uts\|1uts]], [[1uui\|1uui]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uts\|1uts]], [[1uui\|1uui]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [http://pdbe.org/1uud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [http://www.ebi.ac.uk/pdbsum/1uud PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [http://pdbe.org/1uud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [http://www.ebi.ac.uk/pdbsum/1uud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uud ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:11, 10 September 2015

OCA — Thu, 10 Sep 2015 01:11:16 GMT

←Older revision		Revision as of 01:11, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uts\|1uts]], [[1uui\|1uui]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uts\|1uts]], [[1uui\|1uui]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [http://www.ebi.ac.uk/pdbsum/1uud PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [http://pdbe.org/1uud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [http://www.ebi.ac.uk/pdbsum/1uud PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uud" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:42, 22 January 2015

OCA — Thu, 22 Jan 2015 06:42:37 GMT

←Older revision		Revision as of 06:42, 22 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aboul-Ela, F.]]	+	[[Category: Aboul-Ela, F]]
-	[[Category: Afshar, M.]]	+	[[Category: Afshar, M]]
-	[[Category: Bower, J.]]	+	[[Category: Bower, J]]
-	[[Category: Davis, B.]]	+	[[Category: Davis, B]]
-	[[Category: Drysdale, M J.]]	+	[[Category: Drysdale, M J]]
-	[[Category: Karn, J.]]	+	[[Category: Karn, J]]
-	[[Category: Lentzen, G.]]	+	[[Category: Lentzen, G]]
-	[[Category: Murchie, A I.H.]]	+	[[Category: Murchie, A I.H]]
-	[[Category: Potter, A J.]]	+	[[Category: Potter, A J]]
-	[[Category: Varani, G.]]	+	[[Category: Varani, G]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Hiv-1]]		[[Category: Hiv-1]]

OCA at 11:29, 20 October 2014

OCA — Mon, 20 Oct 2014 11:29:35 GMT

←Older revision		Revision as of 11:29, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1uud.~~png~~\|~~left~~\|~~200px~~]]	+	==NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT203, BOUND TO HIV-1 TAR RNA==
		+	<StructureSection load='1uud' size='340' side='right' caption='[[1uud]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UUD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P14:N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE'>P14</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uts\|1uts]], [[1uui\|1uui]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uud OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uud RCSB], [http://www.ebi.ac.uk/pdbsum/1uud PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The targeting of RNA for the design of novel anti-viral compounds has until now proceeded largely without incorporating direct input from structure-based design methodology, partly because of lack of structural data, and complications arising from substrate flexibility. We propose a paradigm to explain the physical mechanism for ligand-induced refolding of trans-activation response element (TAR RNA) from human immunodeficiency virus 1 (HIV-1). Based upon Poisson-Boltzmann analysis of the TAR structure, as bound by a peptide derived from the transcriptional activator protein, Tat, our hypothesis shows that two specific electrostatic interactions are necessary to stabilise the conformation. This result contradicts the belief that a single argininamide residue is responsible for stabilising the TAR fold, as well as the conventional wisdom that electrostatic interactions with RNA are non-specific or dominated by phosphates. We test this hypothesis by using NMR and computational methods to model the interaction of a series of novel inhibitors of the in vitro RNA-binding activities for a peptide derived from Tat. A subset of inhibitors, including the bis-guanidine compound rbt203 and its analogues, induce a conformation in TAR similar to that brought about by the protein. Comparison of the interactions of two of these ligands with the RNA and structure-activity relationships observed within the compound series, confirm the importance of the two specific electrostatic interactions in the stabilisation of the Tat-bound RNA conformation. This work illustrates how the use of medicinal chemistry and structural analysis can provide a rational basis for prediction of ligand-induced conformational change, a necessary step towards the application of structure-based methods in the design of novel RNA or protein-binding drugs.

-	~~{{STRUCTURE_1uud\| PDB=1uud \| SCENE= }}~~	+	Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".,Davis B, Afshar M, Varani G, Murchie AI, Karn J, Lentzen G, Drysdale M, Bower J, Potter AJ, Starkey ID, Swarbrick T, Aboul-ela F J Mol Biol. 2004 Feb 13;336(2):343-56. PMID:14757049<ref>PMID:14757049</ref>

-	~~===NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE~~, ~~RBT203, BOUND TO HIV-1 TAR RNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14757049}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1uud]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1UUD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014757049<~~/~~ref~~><~~ref group="xtra">PMID:007563092</ref><references group="xtra"~~/>	+
	[[Category: Aboul-Ela, F.]]		[[Category: Aboul-Ela, F.]]
	[[Category: Afshar, M.]]		[[Category: Afshar, M.]]

OCA at 09:43, 16 January 2013

OCA — Wed, 16 Jan 2013 09:43:55 GMT

←Older revision		Revision as of 09:43, 16 January 2013
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	[[Image:1uud.png\|left\|200px]]		[[Image:1uud.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1uud", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1uud\| PDB=1uud \| SCENE= }}		{{STRUCTURE_1uud\| PDB=1uud \| SCENE= }}

	===NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT203, BOUND TO HIV-1 TAR RNA===		===NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT203, BOUND TO HIV-1 TAR RNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14757049}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14757049 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14757049}}		{{ABSTRACT_PUBMED_14757049}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14757049~~</ref><ref group="xtra">PMID:~~7563092~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014757049</ref><ref group="xtra">PMID:007563092</ref><references group="xtra"/>
	[[Category: Aboul-Ela, F.]]		[[Category: Aboul-Ela, F.]]
	[[Category: Afshar, M.]]		[[Category: Afshar, M.]]

OCA: Protected "1uud" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 19:14:47 GMT

Protected "1uud" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:14, 14 March 2011

OCA at 19:14, 14 March 2011

OCA — Mon, 14 Mar 2011 19:14:46 GMT

←Older revision		Revision as of 19:14, 14 March 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1uud.png\|left\|200px]]		[[Image:1uud.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~1UUD is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA].	+	[[1uud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUD OCA].

	==Reference==		==Reference==
-	~~Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic~~ "~~hot spots~~"~~., Davis B, Afshar M, Varani G, Murchie AI, Karn J, Lentzen G, Drysdale M, Bower J, Potter AJ, Starkey ID, Swarbrick T, Aboul-ela F, J Mol Biol. 2004 Feb 13;336(2)~~:~~343-56.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/14757049 14757049]~~	+	<ref group="xtra">PMID:14757049</ref><ref group="xtra">PMID:7563092</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Aboul-Ela, F.]]		[[Category: Aboul-Ela, F.]]
	[[Category: Afshar, M.]]		[[Category: Afshar, M.]]
Line 40:		Line 38:
	[[Category: Rna bulge]]		[[Category: Rna bulge]]
	[[Category: Tar rna]]		[[Category: Tar rna]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:03:04 2008''