1uw6 - Revision history

OCA at 13:01, 13 December 2023

OCA — Wed, 13 Dec 2023 13:01:09 GMT

←Older revision		Revision as of 13:01, 13 December 2023
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	<StructureSection load='1uw6' size='340' side='right'caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1uw6' size='340' side='right'caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Great_pond_snail Great pond snail~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN~~-2~~-YL)PYRIDINE'>NCT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [https://pdbe.org/1uw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [https://pdbe.org/1uw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.	+	[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST] Binds to acetylcholine. Modulates neuronal synaptic transmission.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Great pond snail]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brejc, K~~]]	+	[[Category: Lymnaea stagnalis]]
-	[[Category: ~~Celie, P H.N~~]]	+	[[Category: Brejc K]]
-	[[Category: ~~Dijk, W J.Van]]~~	+	[[Category: Celie PHN]]
-	~~[[Category: Rossum-fikkert, S E.Van~~]]	+	[[Category: Sixma TK]]
-	[[Category: Sixma~~, T K~~]]	+	[[Category: Smit AB]]
-	[[Category: Smit~~, A B~~]]	+	[[Category: Van Dijk WJ]]
-	[[Category: ~~Acetylcholine~~]]	+	[[Category: Van Rossum-fikkert SE]]
-	[[Category: ~~Glycoprotein]]~~	+
-	~~[[Category: Igg fold]]~~	+
-	~~[[Category: Nicotine]]~~	+
-	~~[[Category: Pentamer~~]]	+

OCA at 06:19, 6 October 2021

OCA — Wed, 06 Oct 2021 06:19:11 GMT

←Older revision		Revision as of 06:19, 6 October 2021
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	<StructureSection load='1uw6' size='340' side='right'caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1uw6' size='340' side='right'caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [~~http~~://pdbe.org/1uw6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uw6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [https://pdbe.org/1uw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.	+	[[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:39, 1 January 2020

OCA — Wed, 01 Jan 2020 12:39:14 GMT

←Older revision		Revision as of 12:39, 1 January 2020
Line 1:		Line 1:

	==X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine==		==X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine==
-	<StructureSection load='1uw6' size='340' side='right' caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1uw6' size='340' side='right'caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	*[[Cation-pi interactions\|Cation-pi interactions]]		*[[Cation-pi interactions\|Cation-pi interactions]]
	== References ==		== References ==
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Great pond snail]]		[[Category: Great pond snail]]
		+	[[Category: Large Structures]]
	[[Category: Brejc, K]]		[[Category: Brejc, K]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]

OCA at 07:29, 28 March 2018

OCA — Wed, 28 Mar 2018 07:29:07 GMT

←Older revision		Revision as of 07:29, 28 March 2018
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-	==X-~~RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN~~ (~~ACHBP~~) ~~IN COMPLEX WITH NICOTINE~~==	+
		+	==X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine==
	<StructureSection load='1uw6' size='340' side='right' caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1uw6' size='340' side='right' caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://pdbe.org/1uw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://pdbe.org/1uw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uw6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uw6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 41:
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Dijk, W J.Van]]		[[Category: Dijk, W J.Van]]
-	[[Category: Rossum-~~Fikkert~~, S E.Van]]	+	[[Category: Rossum-fikkert, S E.Van]]
	[[Category: Sixma, T K]]		[[Category: Sixma, T K]]
	[[Category: Smit, A B]]		[[Category: Smit, A B]]

OCA at 08:03, 7 February 2016

OCA — Sun, 07 Feb 2016 08:03:54 GMT

←Older revision		Revision as of 08:03, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uw6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:28, 9 September 2015

OCA — Wed, 09 Sep 2015 23:28:04 GMT

←Older revision		Revision as of 23:28, 9 September 2015
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	<StructureSection load='1uw6' size='340' side='right' caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1uw6' size='340' side='right' caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lymnaea_stagnalis Lymnaea stagnalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://pdbe.org/1uw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uw6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lymnaea stagnalis~~]]	+	[[Category: Great pond snail]]
	[[Category: Brejc, K]]		[[Category: Brejc, K]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]

OCA at 13:32, 24 December 2014

OCA — Wed, 24 Dec 2014 13:32:13 GMT

←Older revision		Revision as of 13:32, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Lymnaea stagnalis]]		[[Category: Lymnaea stagnalis]]
-	[[Category: Brejc, K.]]	+	[[Category: Brejc, K]]
-	[[Category: Celie, P H.N.]]	+	[[Category: Celie, P H.N]]
-	[[Category: Dijk, W J.Van.]]	+	[[Category: Dijk, W J.Van]]
-	[[Category: Rossum-Fikkert, S E.Van.]]	+	[[Category: Rossum-Fikkert, S E.Van]]
-	[[Category: Sixma, T K.]]	+	[[Category: Sixma, T K]]
-	[[Category: Smit, A B.]]	+	[[Category: Smit, A B]]
	[[Category: Acetylcholine]]		[[Category: Acetylcholine]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 21:28, 28 September 2014

OCA — Sun, 28 Sep 2014 21:28:32 GMT

←Older revision		Revision as of 21:28, 28 September 2014
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-	[[~~Image:~~1uw6.~~png~~\|~~left~~\|200px]]	+	==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE==
		+	<StructureSection load='1uw6' size='340' side='right' caption='[[1uw6]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1i9b\|1i9b]], [[1uv6\|1uv6]], [[1ux2\|1ux2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw6 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uw6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABAA, GABAC, 5HT3 serotonin, and glycine receptors. Ligand binding is driven by enthalpy and is accompanied by conformational changes in the ligand binding site. Residues in the binding site contract around the ligand, with the largest movement in the C loop. As expected, the binding is characterized by substantial aromatic and hydrophobic contributions, but additionally there are close contacts between protein oxygens and positively charged groups in the ligands. The higher affinity of nicotine is due to a main chain hydrogen bond with the B loop and a closer packing of the aromatic groups. These structures will be useful tools for the development of new drugs involving nicotinic acetylcholine receptor-associated diseases.

-	~~{{STRUCTURE_1uw6\| PDB=1uw6 \| SCENE= }}~~	+	Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.,Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB, Sixma TK Neuron. 2004 Mar 25;41(6):907-14. PMID:15046723<ref>PMID:15046723</ref>

-	~~===X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15046723}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1uw6]] is~~ a ~~20 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA].~~	+

	==See Also==		==See Also==
	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]		*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
	*[[Cation-pi interactions\|Cation-pi interactions]]		*[[Cation-pi interactions\|Cation-pi interactions]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015046723<~~/~~ref~~><~~ref group="xtra">PMID:011357122</ref><ref group="xtra">PMID:011357121</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Lymnaea stagnalis]]		[[Category: Lymnaea stagnalis]]
	[[Category: Brejc, K.]]		[[Category: Brejc, K.]]

OCA at 06:03, 20 October 2012

OCA — Sat, 20 Oct 2012 06:03:39 GMT

←Older revision		Revision as of 06:03, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1uw6]] is a 20 chain structure ~~of [[Acetylcholine binding protein]] and [[Cation-pi interactions]]~~ with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA].	+	[[1uw6]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW6 OCA].

	==See Also==		==See Also==

OCA at 11:58, 25 July 2012

OCA — Wed, 25 Jul 2012 11:58:59 GMT

←Older revision		Revision as of 11:58, 25 July 2012
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	[[Image:1uw6.png\|left\|200px]]		[[Image:1uw6.png\|left\|200px]]

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	===X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE===		===X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH NICOTINE===

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	==See Also==		==See Also==
-	*[[Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
-	*[[Cation-pi interactions]]	+	*[[Cation-pi interactions\|Cation-pi interactions]]

	==Reference==		==Reference==