1uw7 - Revision history

OCA at 09:05, 9 May 2024

OCA — Thu, 09 May 2024 09:05:59 GMT

←Older revision		Revision as of 09:05, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1uw7' size='340' side='right'caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1uw7' size='340' side='right'caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Sars_coronavirus_hku~~-39849 ~~Sars~~ coronavirus ~~hku~~-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_HKU-39849 SARS coronavirus HKU-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1p9t\|1p9t]]~~, [[~~1puk~~\|~~1puk~~]]~~, [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [https://pdbe.org/1uw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [https://pdbe.org/1uw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~R1AB_CVHSA R1AB_CVHSA~~]~~] The replicase polyprotein of coronaviruses is a multifunctional~~ protein~~: it contains the activities necessary for~~ the transcription ~~of negative stranded RNA, leader RNA, subgenomic mRNAs~~ and ~~progeny virion RNA as well as~~ proteinases responsible for the ~~cleavage~~ of the polyprotein ~~into functional products (~~By ~~similarity~~).<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~The papain-like proteinase (PL-PRO) is responsible~~ for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host ~~IRF~~-3.<ref>PMID:~~17024178~~</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> ~~The main proteinase 3CL~~-~~PRO is responsible~~ for ~~the majority of cleavages as it cleaves~~ the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]~~. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity)~~. Also ~~contains~~ an ADP-ribose-1''-phosphate (ADRP)~~-binding function~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~The helicase which contains~~ a ~~zinc finger structure displays RNA and DNA duplex-unwinding activities~~ with ~~5' to 3' polarity. Its ATPase activity is strongly stimulated by poly~~(U)~~, poly(dT), poly(C), poly(dA), but not~~ by ~~poly(G)~~. ~~Activity of helicase is dependent on magnesium~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~The exoribonuclease acts on both ssRNA and dsRNA in~~ a 3' to 5' ~~direction~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~Nsp7-nsp8 hexadecamer may possibly confer processivity~~ to ~~the polymerase~~, ~~maybe by binding to dsRNA or by producing primers utilized by~~ the ~~latter~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~Nsp9 is a ssRNA-binding protein.~~<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~NendoU is a~~ Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> ~~<ref>PMID:19369340</ref>~~	+	[https://www.uniprot.org/uniprot/R1AB_SARS R1AB_SARS] Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).<ref>PMID:23035226</ref> <ref>PMID:30943371</ref> May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>PMID:19640993</ref> Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF-kappa-B signaling.<ref>PMID:16271890</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> <ref>PMID:24622840</ref> <ref>PMID:24410069</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.<ref>PMID:23943763</ref> <ref>PMID:24410069</ref> Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.[PROSITE-ProRule:PRU00772]<ref>PMID:16226257</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).<ref>PMID:24991833</ref> <ref>PMID:24410069</ref> Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> May participate in viral replication by acting as a ssRNA-binding protein.<ref>PMID:19153232</ref> Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.<ref>PMID:22635272</ref> Responsible for replication and transcription of the viral RNA genome.<ref>PMID:22791111</ref> Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.<ref>PMID:12917423</ref> <ref>PMID:22615777</ref> Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity (PubMed:16549795, PubMed:20421945, PubMed:22635272). Acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens (PubMed:23966862, PubMed:29511076, PubMed:21593585).<ref>PMID:16549795</ref> <ref>PMID:20421945</ref> <ref>PMID:21593585</ref> <ref>PMID:22635272</ref> <ref>PMID:23966862</ref> <ref>PMID:29511076</ref> Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.<ref>PMID:18417574</ref> <ref>PMID:20421945</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sars~~ coronavirus ~~hku~~-39849]]	+	[[Category: SARS coronavirus HKU-39849]]
-	[[Category: Alderton, D]]	+	[[Category: Alderton D]]
-	[[Category: Berrow, N]]	+	[[Category: Berrow N]]
-	[[Category: Carter, L]]	+	[[Category: Carter L]]
-	[[Category: Davidson, A]]	+	[[Category: Davidson A]]
-	[[Category: Diprose, J]]	+	[[Category: Diprose J]]
-	[[Category: Fry, E]]	+	[[Category: Fry E]]
-	[[Category: Gilbert, R]]	+	[[Category: Gilbert R]]
-	[[Category: Grimes~~, J M~~]]	+	[[Category: Grimes JM]]
-	[[Category: Nettleship, J]]	+	[[Category: Nettleship J]]
-	[[Category: Owens, R]]	+	[[Category: Owens R]]
-	[[Category: Poon~~, L L.M~~]]	+	[[Category: Poon LLM]]
-	[[Category: Sainsbury, S]]	+	[[Category: Sainsbury S]]
-	[[Category: Siddell, S]]	+	[[Category: Siddell S]]
-	[[Category: Stuart~~, D I~~]]	+	[[Category: Stuart DI]]
-	[[Category: Sutton, G]]	+	[[Category: Sutton G]]
-	[[Category: Walsh, M]]	+	[[Category: Walsh M]]
-	[[Category: Walter, T]]	+	[[Category: Walter T]]
-	~~[[Category: Coronavirus]]~~	+
-	~~[[Category: Replicase protein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Sar]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 10:29, 17 February 2021

OCA — Wed, 17 Feb 2021 10:29:09 GMT

←Older revision		Revision as of 10:29, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='1uw7' size='340' side='right'caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1uw7' size='340' side='right'caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [~~http~~://pdbe.org/1uw7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uw7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [https://pdbe.org/1uw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [https://www.ebi.ac.uk/pdbsum/1uw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/R1AB_CVHSA R1AB_CVHSA]] The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products (By similarity).<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>	+	[[https://www.uniprot.org/uniprot/R1AB_CVHSA R1AB_CVHSA]] The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products (By similarity).<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:45, 10 May 2019

OCA — Fri, 10 May 2019 11:45:02 GMT

←Older revision		Revision as of 11:45, 10 May 2019
Line 1:		Line 1:

	==Nsp9 protein from SARS-coronavirus.==		==Nsp9 protein from SARS-coronavirus.==
-	<StructureSection load='1uw7' size='340' side='right' caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1uw7' size='340' side='right'caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sars coronavirus hku-39849]]		[[Category: Sars coronavirus hku-39849]]
	[[Category: Alderton, D]]		[[Category: Alderton, D]]

OCA at 08:16, 28 March 2018

OCA — Wed, 28 Mar 2018 08:16:33 GMT

←Older revision		Revision as of 08:16, 28 March 2018
Line 1:		Line 1:
		+
	==Nsp9 protein from SARS-coronavirus.==		==Nsp9 protein from SARS-coronavirus.==
	<StructureSection load='1uw7' size='340' side='right' caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1uw7' size='340' side='right' caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://pdbe.org/1uw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://pdbe.org/1uw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uw7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uw7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uw7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:54, 11 September 2015

OCA — Fri, 11 Sep 2015 08:54:19 GMT

←Older revision		Revision as of 08:54, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://pdbe.org/1uw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uw7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:32, 12 February 2015

OCA — Thu, 12 Feb 2015 06:32:09 GMT

←Older revision		Revision as of 06:32, 12 February 2015
Line 1:		Line 1:
-	==~~NSP9 PROTEIN FROM~~ SARS-~~CORONAVIRUS~~.==	+	==Nsp9 protein from SARS-coronavirus.==
	<StructureSection load='1uw7' size='340' side='right' caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1uw7' size='340' side='right' caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_hku-39849 Sars coronavirus hku-39849]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/R1AB_CVHSA R1AB_CVHSA]] The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products (By similarity).<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Viruses~~]]	+	[[Category: Sars coronavirus hku-39849]]
	[[Category: Alderton, D]]		[[Category: Alderton, D]]
	[[Category: Berrow, N]]		[[Category: Berrow, N]]

OCA at 14:06, 6 January 2015

OCA — Tue, 06 Jan 2015 14:06:35 GMT

←Older revision		Revision as of 14:06, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Viruses]]		[[Category: Viruses]]
-	[[Category: Alderton, D.]]	+	[[Category: Alderton, D]]
-	[[Category: Berrow, N.]]	+	[[Category: Berrow, N]]
-	[[Category: Carter, L.]]	+	[[Category: Carter, L]]
-	[[Category: Davidson, A.]]	+	[[Category: Davidson, A]]
-	[[Category: Diprose, J.]]	+	[[Category: Diprose, J]]
-	[[Category: Fry, E.]]	+	[[Category: Fry, E]]
-	[[Category: Gilbert, R.]]	+	[[Category: Gilbert, R]]
-	[[Category: Grimes, J M.]]	+	[[Category: Grimes, J M]]
-	[[Category: Nettleship, J.]]	+	[[Category: Nettleship, J]]
-	[[Category: Owens, R.]]	+	[[Category: Owens, R]]
-	[[Category: Poon, L L.M.]]	+	[[Category: Poon, L L.M]]
-	[[Category: Sainsbury, S.]]	+	[[Category: Sainsbury, S]]
-	[[Category: Siddell, S.]]	+	[[Category: Siddell, S]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
-	[[Category: Sutton, G.]]	+	[[Category: Sutton, G]]
-	[[Category: Walsh, M.]]	+	[[Category: Walsh, M]]
-	[[Category: Walter, T.]]	+	[[Category: Walter, T]]
	[[Category: Coronavirus]]		[[Category: Coronavirus]]
	[[Category: Replicase protein]]		[[Category: Replicase protein]]

OCA at 21:12, 29 September 2014

OCA — Mon, 29 Sep 2014 21:12:21 GMT

←Older revision		Revision as of 21:12, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1uw7.~~png~~\|~~left~~\|200px]]	+	==NSP9 PROTEIN FROM SARS-CORONAVIRUS.==
		+	<StructureSection load='1uw7' size='340' side='right' caption='[[1uw7]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UW7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p9t\|1p9t]], [[1puk\|1puk]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uw7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uw7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/1uw7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As part of a high-throughput structural analysis of SARS-coronavirus (SARS-CoV) proteins, we have solved the structure of the non-structural protein 9 (nsp9). This protein, encoded by ORF1a, has no designated function but is most likely involved with viral RNA synthesis. The protein comprises a single beta-barrel with a fold previously unseen in single domain proteins. The fold superficially resembles an OB-fold with a C-terminal extension and is related to both of the two subdomains of the SARS-CoV 3C-like protease (which belongs to the serine protease superfamily). nsp9 has, presumably, evolved from a protease. The crystal structure suggests that the protein is dimeric. This is confirmed by analytical ultracentrifugation and dynamic light scattering. We show that nsp9 binds RNA and interacts with nsp8, activities that may be essential for its function(s).

-	~~{{STRUCTURE_1uw7\| PDB=1uw7 \| SCENE= }}~~	+	The nsp9 replicase protein of SARS-coronavirus, structure and functional insights.,Sutton G, Fry E, Carter L, Sainsbury S, Walter T, Nettleship J, Berrow N, Owens R, Gilbert R, Davidson A, Siddell S, Poon LL, Diprose J, Alderton D, Walsh M, Grimes JM, Stuart DI Structure. 2004 Feb;12(2):341-53. PMID:14962394<ref>PMID:14962394</ref>

-	~~===NSP9 PROTEIN FROM SARS-CORONAVIRUS.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14962394}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1uw7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Viruses Viruses]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014962394<~~/~~ref~~><~~ref group="xtra">PMID:015630477</ref><references group="xtra"~~/>	+
	[[Category: Viruses]]		[[Category: Viruses]]
	[[Category: Alderton, D.]]		[[Category: Alderton, D.]]

OCA: Protected "1uw7" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:17:32 GMT

Protected "1uw7" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:17, 5 January 2013

OCA at 12:17, 5 January 2013

OCA — Sat, 05 Jan 2013 12:17:29 GMT

←Older revision		Revision as of 12:17, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1uw7.png\|left\|200px]]		[[Image:1uw7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1uw7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1uw7\| PDB=1uw7 \| SCENE= }}		{{STRUCTURE_1uw7\| PDB=1uw7 \| SCENE= }}

	===NSP9 PROTEIN FROM SARS-CORONAVIRUS.===		===NSP9 PROTEIN FROM SARS-CORONAVIRUS.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14962394}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14962394 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14962394}}		{{ABSTRACT_PUBMED_14962394}}

	==About this Structure==		==About this Structure==
-	~~1UW7~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA].	+	[[1uw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14962394~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014962394</ref><ref group="xtra">PMID:015630477</ref><references group="xtra"/>
	[[Category: Viruses]]		[[Category: Viruses]]
	[[Category: Alderton, D.]]		[[Category: Alderton, D.]]
Line 48:		Line 36:
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virus]]		[[Category: Virus]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:16:25 2009''