1uz3 - Revision history

OCA at 09:06, 9 May 2024

OCA — Thu, 09 May 2024 09:06:50 GMT

←Older revision		Revision as of 09:06, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1uz3' size='340' side='right'caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='1uz3' size='340' side='right'caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1utu~~\|~~1utu~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [https://pdbe.org/1uz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1uz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uz3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [https://pdbe.org/1uz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1uz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uz3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EMSY_HUMAN EMSY_HUMAN] Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.<ref>PMID:14651845</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Basu~~, B P~~]]	+	[[Category: Basu BP]]
-	[[Category: Chavali~~, G B~~]]	+	[[Category: Chavali GB]]
-	[[Category: Doherty~~, A J]]~~	+	[[Category: Doherty AJ]]
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Royal family domain~~]]	+

OCA at 07:08, 24 February 2021

OCA — Wed, 24 Feb 2021 07:08:18 GMT

←Older revision		Revision as of 07:08, 24 February 2021
Line 3:		Line 3:
	<StructureSection load='1uz3' size='340' side='right'caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='1uz3' size='340' side='right'caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1utu\|1utu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [~~http~~://pdbe.org/1uz3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1uz3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1uz3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [https://pdbe.org/1uz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1uz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:07, 23 May 2019

OCA — Thu, 23 May 2019 07:07:21 GMT

←Older revision		Revision as of 07:07, 23 May 2019
Line 1:		Line 1:

	==Crystal structure of novel protein EMSY==		==Crystal structure of novel protein EMSY==
-	<StructureSection load='1uz3' size='340' side='right' caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='1uz3' size='340' side='right'caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Basu, B P]]		[[Category: Basu, B P]]
	[[Category: Chavali, G B]]		[[Category: Chavali, G B]]

OCA at 08:15, 28 March 2018

OCA — Wed, 28 Mar 2018 08:15:45 GMT

←Older revision		Revision as of 08:15, 28 March 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF NOVEL PROTEIN~~ EMSY==	+
		+	==Crystal structure of novel protein EMSY==
	<StructureSection load='1uz3' size='340' side='right' caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='1uz3' size='340' side='right' caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://pdbe.org/1uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://pdbe.org/1uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uz3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uz3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:16, 8 February 2016

OCA — Mon, 08 Feb 2016 12:16:51 GMT

←Older revision		Revision as of 12:16, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uz3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:29, 10 September 2015

OCA — Thu, 10 Sep 2015 11:29:19 GMT

←Older revision		Revision as of 11:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1uz3' size='340' side='right' caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='1uz3' size='340' side='right' caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://pdbe.org/1uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1uz3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Basu, B P]]		[[Category: Basu, B P]]
	[[Category: Chavali, G B]]		[[Category: Chavali, G B]]

OCA at 14:05, 6 January 2015

OCA — Tue, 06 Jan 2015 14:05:13 GMT

←Older revision		Revision as of 14:05, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Basu, B P.]]	+	[[Category: Basu, B P]]
-	[[Category: Chavali, G B.]]	+	[[Category: Chavali, G B]]
-	[[Category: Doherty, A J~~.]]~~	+	[[Category: Doherty, A J]]
-	~~[[Category: Chromatin regulator~~]]	+
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Royal family domain]]		[[Category: Royal family domain]]

OCA at 19:17, 29 September 2014

OCA — Mon, 29 Sep 2014 19:17:52 GMT

←Older revision		Revision as of 19:17, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1uz3.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF NOVEL PROTEIN EMSY==
		+	<StructureSection load='1uz3' size='340' side='right' caption='[[1uz3]], [[Resolution\|resolution]] 1.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UZ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1utu\|1utu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1uz3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uz3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	EMSY is a recently discovered gene encoding a BRCA2-associated protein and is amplified in some sporadic breast and ovarian cancers. The EMSY sequence contains no known domain except for a conserved approximately 100 residue segment at the N terminus. This so-called ENT domain is unique in the human genome, although multiple copies are found in Arabidopsis proteins containing members of the Royal family of chromatin remodelling domains. Here, we report the crystal structure of the ENT domain of EMSY, consisting of a unique arrangement of five alpha-helices that fold into a helical bundle arrangement. The fold shares regions of structural homology with the DNA-binding domain of homeodomain proteins. The ENT domain forms a homodimer via the anti-parallel packing of the extended N-terminal alpha-helix of each molecule. It is stabilized mainly by hydrophobic residues at the dimer interface and has a dissociation constant in the low micromolar range. The dimerisation of EMSY mediated by the ENT domain could provide flexibility for it to bind two or more different substrates simultaneously.

-	~~{{STRUCTURE_1uz3\| PDB=1uz3 \| SCENE= }}~~	+	Crystal structure of the ENT domain of human EMSY.,Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, Kouzarides T, Itzhaki LS, Doherty AJ J Mol Biol. 2005 Jul 29;350(5):964-73. PMID:15978617<ref>PMID:15978617</ref>

-	~~===CRYSTAL STRUCTURE OF NOVEL PROTEIN EMSY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15978617}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1uz3]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015978617<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Basu, B P.]]		[[Category: Basu, B P.]]

OCA: Protected "1uz3" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:15:54 GMT

Protected "1uz3" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:15, 5 January 2013

OCA at 12:15, 5 January 2013

OCA — Sat, 05 Jan 2013 12:15:51 GMT

←Older revision		Revision as of 12:15, 5 January 2013
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	[[Image:1uz3.png\|left\|200px]]		[[Image:1uz3.png\|left\|200px]]

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	{{STRUCTURE_1uz3\| PDB=1uz3 \| SCENE= }}		{{STRUCTURE_1uz3\| PDB=1uz3 \| SCENE= }}

	===CRYSTAL STRUCTURE OF NOVEL PROTEIN EMSY===		===CRYSTAL STRUCTURE OF NOVEL PROTEIN EMSY===

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	{{ABSTRACT_PUBMED_15978617}}		{{ABSTRACT_PUBMED_15978617}}

	==About this Structure==		==About this Structure==
-	~~1UZ3~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA].	+	[[1uz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZ3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15978617~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015978617</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Basu, B P.]]		[[Category: Basu, B P.]]
	[[Category: Chavali, G B.]]		[[Category: Chavali, G B.]]
	[[Category: Doherty, A J.]]		[[Category: Doherty, A J.]]
		+	[[Category: Chromatin regulator]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Royal family domain]]		[[Category: Royal family domain]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:56:07 2009''