1v05 - Revision history

OCA at 09:07, 9 May 2024

OCA — Thu, 09 May 2024 09:07:14 GMT

←Older revision		Revision as of 09:07, 9 May 2024
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	<StructureSection load='1v05' size='340' side='right'caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='1v05' size='340' side='right'caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V05 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [https://pdbe.org/1v05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [https://www.ebi.ac.uk/pdbsum/1v05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v05 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.43Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [https://pdbe.org/1v05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [https://www.ebi.ac.uk/pdbsum/1v05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v05 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/FLNC_HUMAN FLNC_HUMAN] Defects in FLNC are the cause of myopathy myofibrillar type 5 (MFM5) [MIM:[https://omim.org/entry/609524 609524]. A neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations, and clinical features of a limb-girdle myopathy.<ref>PMID:15929027</ref> Defects in FLNC are the cause of myopathy distal type 4 (MPD4) [MIM:[https://omim.org/entry/614065 614065]. MPD4 is a slowly progressive muscular disorder characterized by distal muscle weakness and atrophy affecting the upper and lower limbs. Onset occurs around the third to fourth decades of life, and patients remain ambulatory even after long disease duration. Muscle biopsy shows non-specific changes with no evidence of rods, necrosis, or inflammation.<ref>PMID:21620354</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FLNC_HUMAN FLNC_HUMAN] Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kiema, T R]]	+	[[Category: Kiema T-R]]
-	[[Category: Pudas, R]]	+	[[Category: Pudas R]]
-	[[Category: Ylanne, J]]	+	[[Category: Ylanne J]]
-	~~[[Category: Actin-binding protein]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+
	[[Category: Z-disk]]		[[Category: Z-disk]]

OCA at 06:05, 28 April 2021

OCA — Wed, 28 Apr 2021 06:05:44 GMT

←Older revision		Revision as of 06:05, 28 April 2021
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	<StructureSection load='1v05' size='340' side='right'caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='1v05' size='340' side='right'caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V05 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [~~http~~://pdbe.org/1v05 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v05 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v05 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [https://pdbe.org/1v05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [https://www.ebi.ac.uk/pdbsum/1v05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v05 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Filamin 3D structures\|Filamin 3D structures]]		*[[Filamin 3D structures\|Filamin 3D structures]]
-	*[[Group:MUZIC:FilaminC\|MUZIC:FilaminC]]
	*[[User:Georg Mlynek/workbench\|User:Georg Mlynek/workbench]]		*[[User:Georg Mlynek/workbench\|User:Georg Mlynek/workbench]]
	== References ==		== References ==

OCA at 07:05, 24 July 2019

OCA — Wed, 24 Jul 2019 07:05:50 GMT

←Older revision		Revision as of 07:05, 24 July 2019
Line 1:		Line 1:

	==Dimerization of human Filamin C: crystal structure of the domain 24==		==Dimerization of human Filamin C: crystal structure of the domain 24==
-	<StructureSection load='1v05' size='340' side='right' caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>	+	<StructureSection load='1v05' size='340' side='right'caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[Filamin\|Filamin]]	+	*[[Filamin 3D structures\|Filamin 3D structures]]
	*[[Group:MUZIC:FilaminC\|MUZIC:FilaminC]]		*[[Group:MUZIC:FilaminC\|MUZIC:FilaminC]]
	*[[User:Georg Mlynek/workbench\|User:Georg Mlynek/workbench]]		*[[User:Georg Mlynek/workbench\|User:Georg Mlynek/workbench]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kiema, T R]]		[[Category: Kiema, T R]]
	[[Category: Pudas, R]]		[[Category: Pudas, R]]

OCA at 07:54, 28 March 2018

OCA — Wed, 28 Mar 2018 07:54:55 GMT

←Older revision		Revision as of 07:54, 28 March 2018
Line 1:		Line 1:
-	==~~DIMERIZATION OF HUMAN FILAMIN~~ C: ~~CRYSTAL STRUCTURE OF THE DOMAIN~~ 24==	+
		+	==Dimerization of human Filamin C: crystal structure of the domain 24==
	<StructureSection load='1v05' size='340' side='right' caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='1v05' size='340' side='right' caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://pdbe.org/1v05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://pdbe.org/1v05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v05 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v05_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v05_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:13, 9 February 2016

OCA — Tue, 09 Feb 2016 15:13:54 GMT

←Older revision		Revision as of 15:13, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='1v05' size='340' side='right' caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='1v05' size='340' side='right' caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://pdbe.org/1v05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v05 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1v05" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kiema, T R]]		[[Category: Kiema, T R]]
	[[Category: Pudas, R]]		[[Category: Pudas, R]]

OCA at 11:44, 1 July 2015

OCA — Wed, 01 Jul 2015 11:44:44 GMT

←Older revision		Revision as of 11:44, 1 July 2015
Line 38:		Line 38:
	[[Category: Actin-binding protein]]		[[Category: Actin-binding protein]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
		+	[[Category: Z-disk]]

OCA at 13:42, 6 January 2015

OCA — Tue, 06 Jan 2015 13:42:09 GMT

←Older revision		Revision as of 13:42, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kiema, T R.]]	+	[[Category: Kiema, T R]]
-	[[Category: Pudas, R.]]	+	[[Category: Pudas, R]]
-	[[Category: Ylanne, J.]]	+	[[Category: Ylanne, J]]
	[[Category: Actin-binding protein]]		[[Category: Actin-binding protein]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 19:05, 29 September 2014

OCA — Mon, 29 Sep 2014 19:05:55 GMT

←Older revision		Revision as of 19:05, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1v05\| PDB=1v05 \| SCENE= }}~~	+	==DIMERIZATION OF HUMAN FILAMIN C: CRYSTAL STRUCTURE OF THE DOMAIN 24==
-	===DIMERIZATION OF HUMAN FILAMIN C: CRYSTAL STRUCTURE OF THE DOMAIN 24===	+	<StructureSection load='1v05' size='340' side='right' caption='[[1v05]], [[Resolution\|resolution]] 1.43Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15642266}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1v05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V05 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v05 RCSB], [http://www.ebi.ac.uk/pdbsum/1v05 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v05_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Filamins are essential in cell motility and many developmental processes. They are large actin cross linking proteins that contain actin binding domains in their N termini and a long rod region constructed from 24 tandem Ig domains. Dimerization is crucial for the actin crosslinking function of filamins and requires the most C-terminal Ig domain. We describe here the crystal structure of this 24th Ig domain (Ig24) of human filamin C and show how it mediates dimerization. The dimer interface is novel and quite different to that seen in the Dictyostelium discoideum filamin analog. The sequence signature of the dimerization interface suggests that the C-terminal domains of all vertebrate filamins share the same dimerization mechanism. Furthermore, we show that point mutations in the dimerization interface disrupt the dimer and that the dissociation constant for recombinant Ig24 is in the micromolar range.

-	~~==About this~~ Structure==	+	Structural basis for vertebrate filamin dimerization.,Pudas R, Kiema TR, Butler PJ, Stewart M, Ylanne J Structure. 2005 Jan;13(1):111-9. PMID:15642266<ref>PMID:15642266</ref>
-	~~[[1v05]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1V05 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Filamin\|Filamin]]		*[[Filamin\|Filamin]]
	*[[Group:MUZIC:FilaminC\|MUZIC:FilaminC]]		*[[Group:MUZIC:FilaminC\|MUZIC:FilaminC]]
-		+	*[[User:Georg Mlynek/workbench\|User:Georg Mlynek/workbench]]
-	==~~Reference~~==	+	== References ==
-	~~<ref group="xtra">PMID:015642266</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kiema, T R.]]		[[Category: Kiema, T R.]]

OCA at 11:14, 24 March 2013

OCA — Sun, 24 Mar 2013 11:14:43 GMT

←Older revision		Revision as of 11:14, 24 March 2013
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:015642266</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015642266</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kiema, T R.]]		[[Category: Kiema, T R.]]

OCA at 09:56, 11 March 2013

OCA — Mon, 11 Mar 2013 09:56:23 GMT

←Older revision		Revision as of 09:56, 11 March 2013
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-	[[Image:1v05.png\|left\|200px]]
-
	{{STRUCTURE_1v05\| PDB=1v05 \| SCENE= }}		{{STRUCTURE_1v05\| PDB=1v05 \| SCENE= }}
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	===DIMERIZATION OF HUMAN FILAMIN C: CRYSTAL STRUCTURE OF THE DOMAIN 24===		===DIMERIZATION OF HUMAN FILAMIN C: CRYSTAL STRUCTURE OF THE DOMAIN 24===
-
	{{ABSTRACT_PUBMED_15642266}}		{{ABSTRACT_PUBMED_15642266}}