1v1t - Revision history

OCA at 13:07, 13 December 2023

OCA — Wed, 13 Dec 2023 13:07:58 GMT

←Older revision		Revision as of 13:07, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1v1t' size='340' side='right'caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v1t' size='340' side='right'caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V1T FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [https://pdbe.org/1v1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [https://www.ebi.ac.uk/pdbsum/1v1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v1t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [https://pdbe.org/1v1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [https://www.ebi.ac.uk/pdbsum/1v1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v1t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1v1t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1v1t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of syntenin\|3D structures of syntenin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cierpicki, T]]	+	[[Category: Synthetic construct]]
-	[[Category: Cooper~~, D R~~]]	+	[[Category: Cierpicki T]]
-	[[Category: Derewenda, U]]	+	[[Category: Cooper DR]]
-	[[Category: Derewenda~~, Z S~~]]	+	[[Category: Derewenda U]]
-	[[Category: Devedjiev, Y]]	+	[[Category: Derewenda ZS]]
-	[[Category: Grembecka, J]]	+	[[Category: Devedjiev Y]]
-	~~[[Category: Adhesion-complex]]~~	+	[[Category: Grembecka J]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Scaffolding protein~~]]	+

OCA at 09:43, 29 September 2021

OCA — Wed, 29 Sep 2021 09:43:38 GMT

←Older revision		Revision as of 09:43, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1v1t' size='340' side='right'caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v1t' size='340' side='right'caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V1T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [~~http~~://pdbe.org/1v1t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v1t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v1t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [https://pdbe.org/1v1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [https://www.ebi.ac.uk/pdbsum/1v1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v1t ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:34, 10 October 2019

OCA — Thu, 10 Oct 2019 05:34:38 GMT

←Older revision		Revision as of 05:34, 10 October 2019
Line 1:		Line 1:

	==Crystal structure of the PDZ tandem of human syntenin in complex with TNEYKV peptide==		==Crystal structure of the PDZ tandem of human syntenin in complex with TNEYKV peptide==
-	<StructureSection load='1v1t' size='340' side='right' caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1v1t' size='340' side='right'caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V1T FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cierpicki, T]]		[[Category: Cierpicki, T]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]

OCA at 08:16, 28 March 2018

OCA — Wed, 28 Mar 2018 08:16:44 GMT

←Older revision		Revision as of 08:16, 28 March 2018
Line 1:		Line 1:
-	==Crystal structure of the PDZ tandem of human syntenin with TNEYKV peptide==	+
		+	==Crystal structure of the PDZ tandem of human syntenin in complex with TNEYKV peptide==
	<StructureSection load='1v1t' size='340' side='right' caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v1t' size='340' side='right' caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [http://pdbe.org/1v1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [http://www.ebi.ac.uk/pdbsum/1v1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [http://pdbe.org/1v1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [http://www.ebi.ac.uk/pdbsum/1v1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v1t ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/1v1t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/1v1t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:38, 9 February 2016

OCA — Tue, 09 Feb 2016 03:38:38 GMT

←Older revision		Revision as of 03:38, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v1t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:14, 10 September 2015

OCA — Thu, 10 Sep 2015 18:14:55 GMT

←Older revision		Revision as of 18:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1v1t' size='340' side='right' caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v1t' size='340' side='right' caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V1T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [http://www.ebi.ac.uk/pdbsum/1v1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [http://pdbe.org/1v1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [http://www.ebi.ac.uk/pdbsum/1v1t PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1v1t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cierpicki, T]]		[[Category: Cierpicki, T]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]

OCA at 13:13, 6 January 2015

OCA — Tue, 06 Jan 2015 13:13:26 GMT

←Older revision		Revision as of 13:13, 6 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_1v1t\| PDB=1v1t \| SCENE= }}~~	+	==Crystal structure of the PDZ tandem of human syntenin with TNEYKV peptide==
-	===Crystal structure of the PDZ tandem of human syntenin with TNEYKV peptide===	+	<StructureSection load='1v1t' size='340' side='right' caption='[[1v1t]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16533050}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1v1t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V1T FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n99\|1n99]], [[1nte\|1nte]], [[1obx\|1obx]], [[1oby\|1oby]], [[1obz\|1obz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v1t RCSB], [http://www.ebi.ac.uk/pdbsum/1v1t PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/1v1t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PDZ domains are among the most abundant protein modules in the known genomes. Their main function is to provide scaffolds for membrane-associated protein complexes by binding to the cytosolic, C-terminal fragments of receptors, channels, and other integral membrane proteins. Here, using both heteronuclear NMR and single crystal X-ray diffraction, we show how peptides with different sequences, including those corresponding to the C-termini of syndecan, neurexin, and ephrin B, can simultaneously bind to both PDZ domains of the scaffolding protein syntenin. The PDZ2 domain binds these peptides in the canonical fashion, and an induced fit mechanism allows for the accommodation of a range of side chains in the P(0) and P(-)(2) positions. However, binding to the PDZ1 domain requires that the target peptide assume a noncanonical conformation. These data help explain how syntenin, and perhaps other PDZ-containing proteins, may preferentially bind to dimeric and clustered targets, and provide a mechanistic explanation for the previously reported cooperative ligand binding by syntenin's two PDZ domains.

-	~~==About this Structure==~~	+	The binding of the PDZ tandem of syntenin to target proteins.,Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS Biochemistry. 2006 Mar 21;45(11):3674-83. PMID:16533050<ref>PMID:16533050</ref>
-	~~[[1v1t]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:016533050</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cierpicki, T.]]	+	[[Category: Cierpicki, T]]
-	[[Category: Cooper, D R.]]	+	[[Category: Cooper, D R]]
-	[[Category: Derewenda, U.]]	+	[[Category: Derewenda, U]]
-	[[Category: Derewenda, Z S.]]	+	[[Category: Derewenda, Z S]]
-	[[Category: Devedjiev, Y.]]	+	[[Category: Devedjiev, Y]]
-	[[Category: Grembecka, J.]]	+	[[Category: Grembecka, J]]
	[[Category: Adhesion-complex]]		[[Category: Adhesion-complex]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Scaffolding protein]]		[[Category: Scaffolding protein]]

OCA at 08:50, 23 April 2014

OCA — Wed, 23 Apr 2014 08:50:05 GMT

←Older revision		Revision as of 08:50, 23 April 2014
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-	[[Image:1v1t.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1v1t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1v1t\| PDB=1v1t \| SCENE= }}		{{STRUCTURE_1v1t\| PDB=1v1t \| SCENE= }}
-
	===Crystal structure of the PDZ tandem of human syntenin with TNEYKV peptide===		===Crystal structure of the PDZ tandem of human syntenin with TNEYKV peptide===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16533050}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16533050 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16533050}}		{{ABSTRACT_PUBMED_16533050}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:016533050</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016533050</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cierpicki, T.]]		[[Category: Cierpicki, T.]]

OCA: Protected "1v1t" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2012 05:06:39 GMT

Protected "1v1t" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:06, 30 May 2012

OCA at 05:06, 30 May 2012

OCA — Wed, 30 May 2012 05:06:38 GMT

←Older revision		Revision as of 05:06, 30 May 2012
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-	{{Seed}}
	[[Image:1v1t.png\|left\|200px]]		[[Image:1v1t.png\|left\|200px]]

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	{{STRUCTURE_1v1t\| PDB=1v1t \| SCENE= }}		{{STRUCTURE_1v1t\| PDB=1v1t \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF THE~~ PDZ ~~TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH~~ TNEYKV ~~PEPTIDE~~===	+	===Crystal structure of the PDZ tandem of human syntenin with TNEYKV peptide===


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	==About this Structure==		==About this Structure==
-	~~1V1T~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA].	+	[[1v1t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V1T OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16533050~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016533050</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cierpicki, T.]]		[[Category: Cierpicki, T.]]
-	[[Category: Cooper, D.]]	+	[[Category: Cooper, D R.]]
	[[Category: Derewenda, U.]]		[[Category: Derewenda, U.]]
	[[Category: Derewenda, Z S.]]		[[Category: Derewenda, Z S.]]
	[[Category: Devedjiev, Y.]]		[[Category: Devedjiev, Y.]]
	[[Category: Grembecka, J.]]		[[Category: Grembecka, J.]]
		+	[[Category: Adhesion-complex]]
		+	[[Category: Cell adhesion]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Scaffolding protein]]		[[Category: Scaffolding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:10:02 2009''