1v2z - Revision history

OCA at 23:56, 27 December 2023

OCA — Wed, 27 Dec 2023 23:56:58 GMT

←Older revision		Revision as of 23:56, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1v2z' size='340' side='right'caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v2z' size='340' side='right'caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Theeb Theeb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus_BP-1 Thermosynechococcus vestitus BP-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [https://pdbe.org/1v2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [https://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2z ProSAT], [https://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [https://pdbe.org/1v2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [https://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2z ProSAT], [https://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~KAIA_THEEB KAIA_THEEB~~]~~] Component~~ of the KaiABC ~~clock protein~~ complex, which constitutes the main circadian regulator in cyanobacteria. ~~The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription~~, ~~possibly by acting on~~ the ~~state of chromosome compaction~~. In the complex, ~~it enhances~~ the ~~phosphorylation status of KaiC~~. ~~In contrast~~, the ~~presence of~~ KaiB ~~in the~~ complex ~~decreases the phosphorylation status~~ of KaiC, ~~suggesting that~~ KaiB ~~acts~~ by ~~antagonizing the interaction between~~ KaiA ~~and~~ KaiC. ~~A KaiA dimer is sufficient~~ to ~~enhance KaiC hexamer phosphorylation~~.	+	[https://www.uniprot.org/uniprot/KAIA_THEVB KAIA_THEVB] Key component of the KaiABC oscillator complex, which constitutes the main circadian regulator in cyanobacteria. Complex composition changes during the circadian cycle to control KaiC phosphorylation. KaiA stimulates KaiC autophosphorylation, while KaiB sequesters KaiA, leading to KaiC autodephosphorylation. KaiA binding to the KaiC CII domain during the subjective day yields KaiA(2-4):KaiC(6) complexes which stimulate KaiC autophosphorylation. Phospho-Ser-431 KaiC accumulation triggers binding of KaiB during the subjective night to form the KaiB(6):KaiC(6) complex, leading to changes in the output regulators CikA and SasA. KaiB(6):KaiC(6) formation exposes a site for KaiA binding on KaiB that sequesters KaiA from KaiC's CII domain, making the KaiC(6):KaiB(6):KaiA(12) complex resulting in KaiC autodephosphorylation. Complete dephosphorylation of KaiC leads to dissociation of KaiA(2):KaiB(1), completing 1 cycle of the Kai oscillator (By similarity). Formation of the KaiB:KaiC complex is promoted by KaiA, helping switch KaiC from its autophosphorylation to autodephosphatase function (PubMed:24112939).[UniProtKB:Q79PF6]<ref>PMID:24112939</ref> Binds oxidized quinones via the N-terminal PsR domain, allowing it to sense redox changes and possibly mediate clock input.[UniProtKB:Q79PF6]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Theeb~~]]	+	[[Category: Thermosynechococcus vestitus BP-1]]
-	[[Category: Fujita, M]]	+	[[Category: Fujita M]]
-	[[Category: Hayashi, F]]	+	[[Category: Hayashi F]]
-	[[Category: Ishiura, M]]	+	[[Category: Ishiura M]]
-	[[Category: Itoh, N]]	+	[[Category: Itoh N]]
-	[[Category: Kato, H]]	+	[[Category: Kato H]]
-	[[Category: Nakatsu, T]]	+	[[Category: Nakatsu T]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shibata H]]
-	[[Category: Shibata, H]]	+	[[Category: Uzumaki T]]
-	[[Category: Uzumaki, T]]	+
-	~~[[Category: All alpha]]~~	+
-	~~[[Category: Circadian clock protein]]~~	+
-	~~[[Category: Rsgi~~]]	+

OCA at 06:23, 6 October 2021

OCA — Wed, 06 Oct 2021 06:23:35 GMT

←Older revision		Revision as of 06:23, 6 October 2021
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	<StructureSection load='1v2z' size='340' side='right'caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v2z' size='340' side='right'caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [~~http~~://pdbe.org/1v2z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2z ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [https://pdbe.org/1v2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [https://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2z ProSAT], [https://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KAIA_THEEB KAIA_THEEB]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation.	+	[[https://www.uniprot.org/uniprot/KAIA_THEEB KAIA_THEEB]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:40, 1 January 2020

OCA — Wed, 01 Jan 2020 12:40:56 GMT

←Older revision		Revision as of 12:40, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA==		==Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA==
-	<StructureSection load='1v2z' size='340' side='right' caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1v2z' size='340' side='right'caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Circadian clock protein\|Circadian clock protein]]	+	*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Theeb]]		[[Category: Theeb]]
	[[Category: Fujita, M]]		[[Category: Fujita, M]]

OCA at 07:31, 28 March 2018

OCA — Wed, 28 Mar 2018 07:31:02 GMT

←Older revision		Revision as of 07:31, 28 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA==		==Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA==
	<StructureSection load='1v2z' size='340' side='right' caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v2z' size='340' side='right' caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://pdbe.org/1v2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://pdbe.org/1v2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2z ProSAT], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/1v2z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/1v2z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:37, 9 February 2016

OCA — Tue, 09 Feb 2016 10:37:10 GMT

←Older revision		Revision as of 10:37, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v2z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:27, 10 September 2015

OCA — Thu, 10 Sep 2015 21:27:19 GMT

←Older revision		Revision as of 21:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1v2z' size='340' side='right' caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1v2z' size='340' side='right' caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermosynechococcus_elongatus Thermosynechococcus elongatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://pdbe.org/1v2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1v2z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermosynechococcus elongatus~~]]	+	[[Category: Theeb]]
	[[Category: Fujita, M]]		[[Category: Fujita, M]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]

OCA at 06:19, 25 December 2014

OCA — Thu, 25 Dec 2014 06:19:07 GMT

←Older revision		Revision as of 06:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAIA_THEEB KAIA_THEEB]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Thermosynechococcus elongatus]]		[[Category: Thermosynechococcus elongatus]]
-	[[Category: Fujita, M.]]	+	[[Category: Fujita, M]]
-	[[Category: Hayashi, F.]]	+	[[Category: Hayashi, F]]
-	[[Category: Ishiura, M.]]	+	[[Category: Ishiura, M]]
-	[[Category: Itoh, N.]]	+	[[Category: Itoh, N]]
-	[[Category: Kato, H.]]	+	[[Category: Kato, H]]
-	[[Category: Nakatsu, T.]]	+	[[Category: Nakatsu, T]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shibata, H.]]	+	[[Category: Shibata, H]]
-	[[Category: Uzumaki, T.]]	+	[[Category: Uzumaki, T]]
	[[Category: All alpha]]		[[Category: All alpha]]
	[[Category: Circadian clock protein]]		[[Category: Circadian clock protein]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]

OCA at 21:43, 29 September 2014

OCA — Mon, 29 Sep 2014 21:43:25 GMT

←Older revision		Revision as of 21:43, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1v2z.~~png\|left~~\|200px]]	+	==Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA==
		+	<StructureSection load='1v2z' size='340' side='right' caption='[[1v2z]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v2z RCSB], [http://www.ebi.ac.uk/pdbsum/1v2z PDBsum], [http://www.topsan.org/Proteins/RSGI/1v2z TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/1v2z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	KaiA, KaiB and KaiC constitute the circadian clock machinery in cyanobacteria, and KaiA activates kaiBC expression whereas KaiC represses it. Here we show that KaiA is composed of three functional domains, the N-terminal amplitude-amplifier domain, the central period-adjuster domain and the C-terminal clock-oscillator domain. The C-terminal domain is responsible for dimer formation, binding to KaiC, enhancing KaiC phosphorylation and generating the circadian oscillations. The X-ray crystal structure at a resolution of 1.8 A of the C-terminal clock-oscillator domain of KaiA from the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1 shows that residue His270, located at the center of a KaiA dimer concavity, is essential to KaiA function. KaiA binding to KaiC probably occurs via the concave surface. On the basis of the structure, we predict the structural roles of the residues that affect circadian oscillations.

-	~~{{STRUCTURE_1v2z\| PDB=1v2z \| SCENE= }}~~	+	Crystal structure of the C-terminal clock-oscillator domain of the cyanobacterial KaiA protein.,Uzumaki T, Fujita M, Nakatsu T, Hayashi F, Shibata H, Itoh N, Kato H, Ishiura M Nat Struct Mol Biol. 2004 Jul;11(7):623-31. Epub 2004 May 30. PMID:15170179<ref>PMID:15170179</ref>

-	~~===Crystal structure~~ of the ~~C-terminal domain~~ of ~~Thermosynechococcus elongatus BP-1 KaiA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15170179}}~~	+	==See Also==
-		+	*[[Circadian clock protein\|Circadian clock protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1v2z~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015170179<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermosynechococcus elongatus]]		[[Category: Thermosynechococcus elongatus]]
	[[Category: Fujita, M.]]		[[Category: Fujita, M.]]

OCA: Protected "1v2z" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:09:16 GMT

Protected "1v2z" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 5 January 2013

OCA at 13:09, 5 January 2013

OCA — Sat, 05 Jan 2013 13:09:13 GMT

←Older revision		Revision as of 13:09, 5 January 2013
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-	{{Seed}}
	[[Image:1v2z.png\|left\|200px]]		[[Image:1v2z.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1v2z\| PDB=1v2z \| SCENE= }}		{{STRUCTURE_1v2z\| PDB=1v2z \| SCENE= }}

	===Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA===		===Crystal structure of the C-terminal domain of Thermosynechococcus elongatus BP-1 KaiA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15170179}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15170179 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15170179}}		{{ABSTRACT_PUBMED_15170179}}

	==About this Structure==		==About this Structure==
-	~~1V2Z~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Bacteria Bacteria~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA].	+	[[1v2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15170179~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015170179</ref><references group="xtra"/>
-	[[Category: ~~Bacteria~~]]	+	[[Category: Thermosynechococcus elongatus]]
	[[Category: Fujita, M.]]		[[Category: Fujita, M.]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
Line 35:		Line 23:
	[[Category: Uzumaki, T.]]		[[Category: Uzumaki, T.]]
	[[Category: All alpha]]		[[Category: All alpha]]
		+	[[Category: Circadian clock protein]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:11:51 2009''