1v8b - Revision history

OCA at 23:59, 27 December 2023

OCA — Wed, 27 Dec 2023 23:59:20 GMT

←Older revision		Revision as of 23:59, 27 December 2023
Line 3:		Line 3:
	<StructureSection load='1v8b' size='340' side='right'caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1v8b' size='340' side='right'caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V8B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase]~~, ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [https://pdbe.org/1v8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [https://www.ebi.ac.uk/pdbsum/1v8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v8b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [https://pdbe.org/1v8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [https://www.ebi.ac.uk/pdbsum/1v8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v8b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SAHH_PLAF7 SAHH_PLAF7]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.[HAMAP-Rule:MF_00563]	+	[https://www.uniprot.org/uniprot/SAHH_PLAF7 SAHH_PLAF7] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.[HAMAP-Rule:MF_00563]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adenosylhomocysteinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Kitade, Y]]	+	[[Category: Kitade Y]]
-	[[Category: Kusakabe, Y]]	+	[[Category: Kusakabe Y]]
-	[[Category: Nakamura~~, K T~~]]	+	[[Category: Nakamura KT]]
-	[[Category: Nakanishi, M]]	+	[[Category: Nakanishi M]]
-	[[Category: Shiraiwa, K]]	+	[[Category: Shiraiwa K]]
-	[[Category: Tanaka, N]]	+	[[Category: Tanaka N]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 06:27, 6 October 2021

OCA — Wed, 06 Oct 2021 06:27:16 GMT

←Older revision		Revision as of 06:27, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1v8b' size='340' side='right'caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1v8b' size='340' side='right'caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V8B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [~~http~~://pdbe.org/1v8b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v8b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v8b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [https://pdbe.org/1v8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [https://www.ebi.ac.uk/pdbsum/1v8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v8b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SAHH_PLAF7 SAHH_PLAF7]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.[HAMAP-Rule:MF_00563]	+	[[https://www.uniprot.org/uniprot/SAHH_PLAF7 SAHH_PLAF7]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.[HAMAP-Rule:MF_00563]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:46, 1 January 2020

OCA — Wed, 01 Jan 2020 12:46:26 GMT

←Older revision		Revision as of 12:46, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of a hydrolase==		==Crystal structure of a hydrolase==
-	<StructureSection load='1v8b' size='340' side='right' caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1v8b' size='340' side='right'caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
		+	[[Category: Large Structures]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
	[[Category: Kitade, Y]]		[[Category: Kitade, Y]]

OCA at 07:35, 28 March 2018

OCA — Wed, 28 Mar 2018 07:35:50 GMT

←Older revision		Revision as of 07:35, 28 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of a hydrolase==		==Crystal structure of a hydrolase==
	<StructureSection load='1v8b' size='340' side='right' caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1v8b' size='340' side='right' caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://pdbe.org/1v8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://pdbe.org/1v8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v8b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v8b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v8b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:21, 9 February 2016

OCA — Tue, 09 Feb 2016 07:21:53 GMT

←Older revision		Revision as of 07:21, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v8b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:55, 10 September 2015

OCA — Thu, 10 Sep 2015 19:55:27 GMT

←Older revision		Revision as of 19:55, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1v8b' size='340' side='right' caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1v8b' size='340' side='right' caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://pdbe.org/1v8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1v8b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: Kitade, Y]]		[[Category: Kitade, Y]]
	[[Category: Kusakabe, Y]]		[[Category: Kusakabe, Y]]

OCA at 05:19, 25 December 2014

OCA — Thu, 25 Dec 2014 05:19:10 GMT

←Older revision		Revision as of 05:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAHH_PLAF7 SAHH_PLAF7]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.[HAMAP-Rule:MF_00563]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Kitade, Y.]]	+	[[Category: Kitade, Y]]
-	[[Category: Kusakabe, Y.]]	+	[[Category: Kusakabe, Y]]
-	[[Category: Nakamura, K T.]]	+	[[Category: Nakamura, K T]]
-	[[Category: Nakanishi, M.]]	+	[[Category: Nakanishi, M]]
-	[[Category: Shiraiwa, K.]]	+	[[Category: Shiraiwa, K]]
-	[[Category: Tanaka, N.]]	+	[[Category: Tanaka, N]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 20:49, 29 September 2014

OCA — Mon, 29 Sep 2014 20:49:08 GMT

←Older revision		Revision as of 20:49, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1v8b.~~png\|left~~\|200px]]	+	==Crystal structure of a hydrolase==
		+	<StructureSection load='1v8b' size='340' side='right' caption='[[1v8b]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V8B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v8b RCSB], [http://www.ebi.ac.uk/pdbsum/1v8b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v8b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human malaria parasite Plasmodium falciparum is responsible for the death of more than a million people each year. The emergence of strains of malarial parasite resistant to conventional drug therapy has stimulated searches for antimalarials with novel modes of action. S-Adenosyl-L-homocysteine hydrolase (SAHH) is a regulator of biological methylations. Inhibitors of SAHH affect the methylation status of nucleic acids, proteins, and small molecules. P.falciparum SAHH (PfSAHH) inhibitors are expected to provide a new type of chemotherapeutic agent against malaria. Despite the pressing need to develop selective PfSAHH inhibitors as therapeutic drugs, only the mammalian SAHH structures are currently available. Here, we report the crystal structure of PfSAHH complexed with the reaction product adenosine (Ado). Knowledge of the structure of the Ado complex in combination with a structural comparison with Homo sapiens SAHH (HsSAHH) revealed that a single substitution between the PfSAHH (Cys59) and HsSAHH (Thr60) accounts for the differential interactions with nucleoside inhibitors. To examine roles of the Cys59 in the interactions with nucleoside inhibitors, a mutant PfSAHH was prepared. A replacement of Cys59 by Thr results in mutant PfSAHH, which shows HsSAHH-like nucleoside inhibitor sensitivity. The present structure should provide opportunities to design potent and selective PfSAHH inhibitors.

-	~~{{STRUCTURE_1v8b\| PDB=1v8b \| SCENE= }}~~	+	Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum.,Tanaka N, Nakanishi M, Kusakabe Y, Shiraiwa K, Yabe S, Ito Y, Kitade Y, Nakamura KT J Mol Biol. 2004 Oct 29;343(4):1007-17. PMID:15476817<ref>PMID:15476817</ref>

-	~~===Crystal structure of~~ a ~~hydrolase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15476817}}~~	+	==See Also==
-		+	*[[S-adenosylhomocysteine hydrolase\|S-adenosylhomocysteine hydrolase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1v8b~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015476817<~~/~~ref~~><~~ref group="xtra">PMID:016516468</ref><references group="xtra"~~/>	+
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA: Protected "1v8b" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:41:51 GMT

Protected "1v8b" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:41, 5 January 2013

OCA at 11:41, 5 January 2013

OCA — Sat, 05 Jan 2013 11:41:48 GMT

←Older revision		Revision as of 11:41, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1v8b.png\|left\|200px]]		[[Image:1v8b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1v8b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1v8b\| PDB=1v8b \| SCENE= }}		{{STRUCTURE_1v8b\| PDB=1v8b \| SCENE= }}

	===Crystal structure of a hydrolase===		===Crystal structure of a hydrolase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15476817}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15476817 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15476817}}		{{ABSTRACT_PUBMED_15476817}}

	==About this Structure==		==About this Structure==
-	~~1V8B~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7~~ Plasmodium falciparum ~~3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA].	+	[[1v8b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V8B OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15476817~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015476817</ref><ref group="xtra">PMID:016516468</ref><references group="xtra"/>
	[[Category: Adenosylhomocysteinase]]		[[Category: Adenosylhomocysteinase]]
-	[[Category: Plasmodium falciparum ~~3d7~~]]	+	[[Category: Plasmodium falciparum]]
	[[Category: Kitade, Y.]]		[[Category: Kitade, Y.]]
	[[Category: Kusakabe, Y.]]		[[Category: Kusakabe, Y.]]
Line 33:		Line 21:
	[[Category: Tanaka, N.]]		[[Category: Tanaka, N.]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:55:27 2009''