1vbs - Revision history

OCA at 06:17, 3 April 2024

OCA — Wed, 03 Apr 2024 06:17:09 GMT

←Older revision		Revision as of 06:17, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='1vbs' size='340' side='right'caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1vbs' size='340' side='right'caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1VBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VBS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=DAL:D~~-~~ALANINE'>DAL</scene>~~, ~~<scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CYCLOPHILIN ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [~~http~~://pdbe.org/1vbs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vbs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vbs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [https://pdbe.org/1vbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [https://www.ebi.ac.uk/pdbsum/1vbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vbs ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vbs ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vbs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The stereospecificity of peptidyl prolyl cis/trans isomerases (PPIases) was studied using tetrapeptide substrate analogs in which one amino acid residue was replaced by the cognate D-amino acid in various positions of the peptide chain. Reversed stereocenters around proline markedly increased the rate of the spontaneous trans to cis isomerization of the prolyl bond whereas cis to trans isomerizations were less sensitive. PPIases like human cyclophilin18, human FKBP12, Escherichia coli parvulin10 and the PPIase domain of E. coli trigger factor exhibited stereoselectivity demanding at the P1 to P2' position of the substrate chain. The discriminating factor for stereoselectivity was the lack of formation of the Michaelis complexes of the diastereomeric substrates. However, D-alanine at the P1 position preserved considerable affinity to the active site, and largely prevented activation of the catalytic machinery for all PPIases investigated.
-
-	Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases.,Schiene C, Reimer U, Schutkowski M, Fischer G FEBS Lett. 1998 Aug 7;432(3):202-6. PMID:9720925<ref>PMID:9720925</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1vbs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]		*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Fischer, G]]	+	[[Category: Fischer G]]
-	[[Category: Ke, H]]	+	[[Category: Ke H]]
-	[[Category: Schutkowski, M]]	+	[[Category: Schutkowski M]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhao Y]]
-	~~[[Category: Competitive inhibitor]]~~	+
-	~~[[Category: Cyclophilin some]]~~	+
-	~~[[Category: Isomerase- isomerase substrate complex]]~~	+
-	~~[[Category: Peptidyl-prolyl isomerase~~]]	+

OCA at 07:34, 30 December 2020

OCA — Wed, 30 Dec 2020 07:34:36 GMT

←Older revision		Revision as of 07:34, 30 December 2020
Line 1:		Line 1:

	==STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE==		==STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE==
-	<StructureSection load='1vbs' size='340' side='right' caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1vbs' size='340' side='right'caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1VBS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://pdbe.org/1vbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vbs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://pdbe.org/1vbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vbs ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Cyclophilin\|Cyclophilin]]	+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Fischer, G]]		[[Category: Fischer, G]]

OCA at 07:41, 4 April 2018

OCA — Wed, 04 Apr 2018 07:41:27 GMT

←Older revision		Revision as of 07:41, 4 April 2018
Line 1:		Line 1:
		+
	==STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE==		==STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE==
	<StructureSection load='1vbs' size='340' side='right' caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1vbs' size='340' side='right' caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://pdbe.org/1vbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://pdbe.org/1vbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vbs ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/1vbs_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/1vbs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vbs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:16, 11 September 2015

OCA — Fri, 11 Sep 2015 16:16:47 GMT

←Older revision		Revision as of 16:16, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1vbs' size='340' side='right' caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1vbs' size='340' side='right' caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VBS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://pdbe.org/1vbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vbs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Fischer, G]]		[[Category: Fischer, G]]

OCA at 13:52, 6 January 2015

OCA — Tue, 06 Jan 2015 13:52:39 GMT

←Older revision		Revision as of 13:52, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VBS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VBS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Fischer, G.]]	+	[[Category: Fischer, G]]
-	[[Category: Ke, H.]]	+	[[Category: Ke, H]]
-	[[Category: Schutkowski, M.]]	+	[[Category: Schutkowski, M]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
	[[Category: Competitive inhibitor]]		[[Category: Competitive inhibitor]]
	[[Category: Cyclophilin some]]		[[Category: Cyclophilin some]]
	[[Category: Isomerase- isomerase substrate complex]]		[[Category: Isomerase- isomerase substrate complex]]
	[[Category: Peptidyl-prolyl isomerase]]		[[Category: Peptidyl-prolyl isomerase]]

OCA at 00:05, 29 September 2014

OCA — Mon, 29 Sep 2014 00:05:34 GMT

←Older revision		Revision as of 00:05, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1vbs.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE==
		+	<StructureSection load='1vbs' size='340' side='right' caption='[[1vbs]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VBS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NIT:4-NITROANILINE'>NIT</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vbs RCSB], [http://www.ebi.ac.uk/pdbsum/1vbs PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/1vbs_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The stereospecificity of peptidyl prolyl cis/trans isomerases (PPIases) was studied using tetrapeptide substrate analogs in which one amino acid residue was replaced by the cognate D-amino acid in various positions of the peptide chain. Reversed stereocenters around proline markedly increased the rate of the spontaneous trans to cis isomerization of the prolyl bond whereas cis to trans isomerizations were less sensitive. PPIases like human cyclophilin18, human FKBP12, Escherichia coli parvulin10 and the PPIase domain of E. coli trigger factor exhibited stereoselectivity demanding at the P1 to P2' position of the substrate chain. The discriminating factor for stereoselectivity was the lack of formation of the Michaelis complexes of the diastereomeric substrates. However, D-alanine at the P1 position preserved considerable affinity to the active site, and largely prevented activation of the catalytic machinery for all PPIases investigated.

-	~~{{STRUCTURE_1vbs\| PDB=1vbs \| SCENE= }}~~	+	Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases.,Schiene C, Reimer U, Schutkowski M, Fischer G FEBS Lett. 1998 Aug 7;432(3):202-6. PMID:9720925<ref>PMID:9720925</ref>

-	~~===STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9720925}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1vbs]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].~~	+

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin\|Cyclophilin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009720925<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]

OCA at 20:13, 20 October 2012

OCA — Sat, 20 Oct 2012 20:13:24 GMT

←Older revision		Revision as of 20:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1vbs]] is a 2 chain structure ~~of [[Cyclophilin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].	+	[[1vbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].

	==See Also==		==See Also==

OCA: Protected "1vbs" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 09:48:06 GMT

Protected "1vbs" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:48, 27 July 2012

OCA at 09:48, 27 July 2012

OCA — Fri, 27 Jul 2012 09:48:04 GMT

←Older revision		Revision as of 09:48, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1vbs.png\|left\|200px]]		[[Image:1vbs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vbs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vbs\| PDB=1vbs \| SCENE= }}		{{STRUCTURE_1vbs\| PDB=1vbs \| SCENE= }}

	===STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE===		===STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9720925}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9720925 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9720925}}		{{ABSTRACT_PUBMED_9720925}}

	==About this Structure==		==About this Structure==
-	~~1VBS~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].	+	[[1vbs]] is a 2 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].
		+
		+	==See Also==
		+	*[[Cyclophilin\|Cyclophilin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9720925~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009720925</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]
Line 32:		Line 23:
	[[Category: Competitive inhibitor]]		[[Category: Competitive inhibitor]]
	[[Category: Cyclophilin some]]		[[Category: Cyclophilin some]]
-	[[Category: ~~Mechanism~~]]	+	[[Category: Isomerase- isomerase substrate complex]]
	[[Category: Peptidyl-prolyl isomerase]]		[[Category: Peptidyl-prolyl isomerase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:29:02 2009''

OCA at 01:29, 18 February 2009

OCA — Wed, 18 Feb 2009 01:29:07 GMT

←Older revision		Revision as of 01:29, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1VBS is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].	+	1VBS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBS OCA].

	==Reference==		==Reference==
-	~~Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases., Schiene C, Reimer U, Schutkowski M, Fischer G, FEBS Lett. 1998 Aug 7;432(3):202-6.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9720925 9720925]~~	+	<ref group="xtra">PMID:9720925</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]
	[[Category: Fischer, G.]]		[[Category: Fischer, G.]]
Line 36:		Line 35:
	[[Category: Peptidyl-prolyl isomerase]]		[[Category: Peptidyl-prolyl isomerase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:48:~~39 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:29:02 2009''