1vco - Revision history

OCA at 00:01, 28 December 2023

OCA — Thu, 28 Dec 2023 00:01:37 GMT

←Older revision		Revision as of 00:01, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='1vco' size='340' side='right'caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1vco' size='340' side='right'caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VCO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1vcm\|1vcm]]~~, [[~~1vcn~~\|~~1vcn~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~274~~ "~~Flavobacterium thermophilum~~" ~~Yoshida and Oshima 1971])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [https://pdbe.org/1vco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [https://www.ebi.ac.uk/pdbsum/1vco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vco ProSAT], [https://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [~~http~~://pdbe.org/1vco PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vco PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vco ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYRG_THET8 PYRG_THET8]] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity).	+	[https://www.uniprot.org/uniprot/PYRG_THET8 PYRG_THET8] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Goto, M~~]]	+	[[Category: Thermus thermophilus]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Goto M]]
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Tetramer~~]]	+

OCA at 07:34, 30 December 2020

OCA — Wed, 30 Dec 2020 07:34:59 GMT

←Older revision		Revision as of 07:34, 30 December 2020
Line 1:		Line 1:

	==Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine==		==Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine==
-	<StructureSection load='1vco' size='340' side='right' caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='1vco' size='340' side='right'caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1VCO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vcm\|1vcm]], [[1vcn\|1vcn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vcm\|1vcm]], [[1vcn\|1vcn]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://pdbe.org/1vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vco ProSAT], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://pdbe.org/1vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vco ProSAT], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]		[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
		+	[[Category: Large Structures]]
	[[Category: Goto, M]]		[[Category: Goto, M]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 07:30, 4 April 2018

OCA — Wed, 04 Apr 2018 07:30:21 GMT

←Older revision		Revision as of 07:30, 4 April 2018
Line 1:		Line 1:
		+
	==Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine==		==Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine==
	<StructureSection load='1vco' size='340' side='right' caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1vco' size='340' side='right' caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://pdbe.org/1vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://pdbe.org/1vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vco ProSAT], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/1vco_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/1vco_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vco ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:48, 11 September 2015

OCA — Fri, 11 Sep 2015 13:48:54 GMT

←Older revision		Revision as of 13:48, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1vco' size='340' side='right' caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1vco' size='340' side='right' caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VCO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vcm\|1vcm]], [[1vcn\|1vcn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vcm\|1vcm]], [[1vcn\|1vcn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 ~~Thermus thermophilus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~CTP_synthase~~ CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://pdbe.org/1vco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vco" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~CTP synthase]]~~	+	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
-	~~[[Category: Thermus thermophilus~~]]	+
	[[Category: Goto, M]]		[[Category: Goto, M]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 17:17, 25 December 2014

OCA — Thu, 25 Dec 2014 17:17:54 GMT

←Older revision		Revision as of 17:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VCO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VCO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vcm\|1vcm]], [[1vcn\|1vcn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vcm\|1vcm]], [[1vcn\|1vcn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYRG_THET8 PYRG_THET8]] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: CTP synthase]]		[[Category: CTP synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Goto, M.]]	+	[[Category: Goto, M]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
	[[Category: Ligase]]		[[Category: Ligase]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Tetramer]]		[[Category: Tetramer]]

OCA at 20:31, 29 September 2014

OCA — Mon, 29 Sep 2014 20:31:01 GMT

←Older revision		Revision as of 20:31, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1vco.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine==
		+	<StructureSection load='1vco' size='340' side='right' caption='[[1vco]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VCO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vcm\|1vcm]], [[1vcn\|1vcn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vco RCSB], [http://www.ebi.ac.uk/pdbsum/1vco PDBsum], [http://www.topsan.org/Proteins/RSGI/1vco TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/1vco_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CTP synthetase (CTPs) catalyzes the last step in CTP biosynthesis, in which ammonia generated at the glutaminase domain reacts with the ATP-phosphorylated UTP at the synthetase domain to give CTP. Glutamine hydrolysis is active in the presence of ATP and UTP and is stimulated by the addition of GTP. We report the crystal structures of Thermus thermophilus HB8 CTPs alone, CTPs with 3SO4(2-), and CTPs with glutamine. The enzyme is folded into a homotetramer with a cross-shaped structure. Based on the binding mode of sulfate anions to the synthetase site, ATP and UTP are computer modeled into CTPs with a geometry favorable for the reaction. Glutamine bound to the glutaminase domain is situated next to the triad of Glu-His-Cys as a catalyst and a water molecule. Structural information provides an insight into the conformational changes associated with the binding of ATP and UTP and the formation of the GTP binding site.

-	~~{{STRUCTURE_1vco\| PDB=1vco \| SCENE= }}~~	+	Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites.,Goto M, Omi R, Nakagawa N, Miyahara I, Hirotsu K Structure. 2004 Aug;12(8):1413-23. PMID:15296735<ref>PMID:15296735</ref>

-	~~===Crystal Structure~~ of T.th. ~~HB8 CTP synthetase complex with Glutamine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15296735}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1vco]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015296735<~~/~~ref~~><~~ref group="xtra">PMID:015157079</ref><references group="xtra"~~/>	+
	[[Category: CTP synthase]]		[[Category: CTP synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]

OCA: Protected "1vco" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:14:52 GMT

Protected "1vco" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:14, 5 January 2013

OCA at 11:14, 5 January 2013

OCA — Sat, 05 Jan 2013 11:14:50 GMT

←Older revision		Revision as of 11:14, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1vco.png\|left\|200px]]		[[Image:1vco.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vco", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vco\| PDB=1vco \| SCENE= }}		{{STRUCTURE_1vco\| PDB=1vco \| SCENE= }}

	===Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine===		===Crystal Structure of T.th. HB8 CTP synthetase complex with Glutamine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15296735}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15296735 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15296735}}		{{ABSTRACT_PUBMED_15296735}}

	==About this Structure==		==About this Structure==
-	~~1VCO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA].	+	[[1vco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15296735~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015296735</ref><ref group="xtra">PMID:015157079</ref><references group="xtra"/>
	[[Category: CTP synthase]]		[[Category: CTP synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Goto, M.]]		[[Category: Goto, M.]]
	[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]		[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
		+	[[Category: Ligase]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Tetramer]]		[[Category: Tetramer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:59:02 2009''

OCA at 21:59, 17 February 2009

OCA — Tue, 17 Feb 2009 21:59:03 GMT

←Older revision		Revision as of 21:59, 17 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
-	~~Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites., Goto M, Omi R, Nakagawa N, Miyahara I, Hirotsu K, Structure. 2004 Aug;12(8):1413-23.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15296735 15296735]~~	+	<ref group="xtra">PMID:15296735</ref><references group="xtra"/>
	[[Category: CTP synthase]]		[[Category: CTP synthase]]
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
Line 33:		Line 33:
	[[Category: Tetramer]]		[[Category: Tetramer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 15~~:13:~~05 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:59:02 2009''

OCA at 13:13, 16 November 2008

OCA — Sun, 16 Nov 2008 13:13:08 GMT

←Older revision		Revision as of 13:13, 16 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA].	+	1VCO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCO OCA].

	==Reference==		==Reference==
	Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites., Goto M, Omi R, Nakagawa N, Miyahara I, Hirotsu K, Structure. 2004 Aug;12(8):1413-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15296735 15296735]		Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites., Goto M, Omi R, Nakagawa N, Miyahara I, Hirotsu K, Structure. 2004 Aug;12(8):1413-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15296735 15296735]
	[[Category: CTP synthase]]		[[Category: CTP synthase]]
		+	[[Category: Thermus thermophilus]]
	[[Category: Goto, M.]]		[[Category: Goto, M.]]
	[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]		[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
Line 32:		Line 33:
	[[Category: Tetramer]]		[[Category: Tetramer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 07:~~16:18 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:13:05 2008''