1vdg - Revision history

OCA at 07:52, 25 October 2023

OCA — Wed, 25 Oct 2023 07:52:26 GMT

←Older revision		Revision as of 07:52, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1vdg' size='340' side='right'caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1vdg' size='340' side='right'caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1g0x\|1g0x]]~~, [[~~1ufu~~\|~~1ufu~~]]~~, [[1ugn\|1ugn]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [https://pdbe.org/1vdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [https://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [https://pdbe.org/1vdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [https://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>	+	[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amano, K]]	+	[[Category: Amano K]]
-	[[Category: Kohda, D]]	+	[[Category: Kohda D]]
-	[[Category: Kuroki, K]]	+	[[Category: Kuroki K]]
-	[[Category: Maenaka, K]]	+	[[Category: Maenaka K]]
-	[[Category: Rasubala, L]]	+	[[Category: Rasubala L]]
-	[[Category: Shiroishi, M]]	+	[[Category: Shiroishi M]]
-	[[Category: Tokunaga, K]]	+	[[Category: Tokunaga K]]
-	[[Category: Tsuchiya, N]]	+	[[Category: Tsuchiya N]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin-like~~]]	+

OCA at 13:20, 13 October 2021

OCA — Wed, 13 Oct 2021 13:20:49 GMT

←Older revision		Revision as of 13:20, 13 October 2021
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	<StructureSection load='1vdg' size='340' side='right'caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1vdg' size='340' side='right'caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VDG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [~~http~~://pdbe.org/1vdg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [https://pdbe.org/1vdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [https://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>	+	[[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:35, 8 January 2020

OCA — Wed, 08 Jan 2020 10:35:34 GMT

←Older revision		Revision as of 10:35, 8 January 2020
Line 1:		Line 1:

	==Crystal structure of LIR1.01, one of the alleles of LIR1==		==Crystal structure of LIR1.01, one of the alleles of LIR1==
-	<StructureSection load='1vdg' size='340' side='right' caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1vdg' size='340' side='right'caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Amano, K]]		[[Category: Amano, K]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]

OCA at 07:40, 4 April 2018

OCA — Wed, 04 Apr 2018 07:40:13 GMT

←Older revision		Revision as of 07:40, 4 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of LIR1.01, one of the alleles of LIR1==		==Crystal structure of LIR1.01, one of the alleles of LIR1==
	<StructureSection load='1vdg' size='340' side='right' caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1vdg' size='340' side='right' caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://pdbe.org/1vdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://pdbe.org/1vdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vdg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vdg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:53, 8 February 2016

OCA — Mon, 08 Feb 2016 23:53:38 GMT

←Older revision		Revision as of 23:53, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vdg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 16:35, 10 September 2015

OCA — Thu, 10 Sep 2015 16:35:39 GMT

←Older revision		Revision as of 16:35, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1vdg' size='340' side='right' caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1vdg' size='340' side='right' caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://pdbe.org/1vdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Amano, K]]		[[Category: Amano, K]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]

OCA at 03:01, 25 December 2014

OCA — Thu, 25 Dec 2014 03:01:12 GMT

←Older revision		Revision as of 03:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	==See Also==		==See Also==
	*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]		*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Amano, K.]]	+	[[Category: Amano, K]]
-	[[Category: Kohda, D.]]	+	[[Category: Kohda, D]]
-	[[Category: Kuroki, K.]]	+	[[Category: Kuroki, K]]
-	[[Category: Maenaka, K.]]	+	[[Category: Maenaka, K]]
-	[[Category: Rasubala, L.]]	+	[[Category: Rasubala, L]]
-	[[Category: Shiroishi, M.]]	+	[[Category: Shiroishi, M]]
-	[[Category: Tokunaga, K.]]	+	[[Category: Tokunaga, K]]
-	[[Category: Tsuchiya, N.]]	+	[[Category: Tsuchiya, N]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin-like]]		[[Category: Immunoglobulin-like]]

OCA at 18:40, 29 September 2014

OCA — Mon, 29 Sep 2014 18:40:37 GMT

←Older revision		Revision as of 18:40, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1vdg.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of LIR1.01, one of the alleles of LIR1==
		+	<StructureSection load='1vdg' size='340' side='right' caption='[[1vdg]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g0x\|1g0x]], [[1ufu\|1ufu]], [[1ugn\|1ugn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vdg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

-	~~{{STRUCTURE_1vdg\| PDB~~=~~1vdg \| SCENE~~= }}	+	==See Also==
-		+	*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]
-	~~===Crystal structure of LIR1.01, one of the alleles of LIR1===~~	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure~~==	+
-	[[~~1vdg~~]] ~~is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amano, K.]]		[[Category: Amano, K.]]

OCA: Protected "1vdg" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:23:50 GMT

Protected "1vdg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:23, 5 January 2013

OCA at 11:23, 5 January 2013

OCA — Sat, 05 Jan 2013 11:23:47 GMT

←Older revision		Revision as of 11:23, 5 January 2013
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-	{{Seed}}
	[[Image:1vdg.png\|left\|200px]]		[[Image:1vdg.png\|left\|200px]]

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	{{STRUCTURE_1vdg\| PDB=1vdg \| SCENE= }}		{{STRUCTURE_1vdg\| PDB=1vdg \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~1VDG~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA].	+	[[1vdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amano, K.]]		[[Category: Amano, K.]]
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	[[Category: Tokunaga, K.]]		[[Category: Tokunaga, K.]]
	[[Category: Tsuchiya, N.]]		[[Category: Tsuchiya, N.]]
		+	[[Category: Immune system]]
	[[Category: Immunoglobulin-like]]		[[Category: Immunoglobulin-like]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:39:40 2009''