1vgr - Revision history

OCA at 07:55, 25 October 2023

OCA — Wed, 25 Oct 2023 07:55:58 GMT

←Older revision		Revision as of 07:55, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1vgr' size='340' side='right'caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1vgr' size='340' side='right'caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35274 Atcc 35274~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1p5h\|1p5h]]~~, [[~~1p5r~~\|~~1p5r~~]]~~, [[1vgq\|1vgq]], [[1t3z\|1t3z]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FRC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~847 ATCC 35274])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [https://pdbe.org/1vgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [https://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [https://pdbe.org/1vgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [https://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]	+	[https://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 35274]]
-	[[Category: Formyl-CoA transferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jonsson, S~~]]	+	[[Category: Oxalobacter formigenes]]
-	[[Category: ~~Lindqvist, Y]]~~	+	[[Category: Jonsson S]]
-	~~[[Category: Ricagno,~~ S]]	+	[[Category: Lindqvist Y]]
-	[[Category: ~~Richards, N G~~]]	+	[[Category: Ricagno S]]
-	[[Category: ~~Caib-baif family~~]]	+	[[Category: Richards NG]]
-	[[Category: ~~Coa complex]]~~	+
-	~~[[Category: Coa transferase]]~~	+
-	~~[[Category: Intertwined]]~~	+
-	~~[[Category: Knotted fold]]~~	+
-	~~[[Category: Oxalate]]~~	+
-	~~[[Category: Oxalate degradation]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:35, 10 November 2021

OCA — Wed, 10 Nov 2021 06:35:06 GMT

OCA at 07:36, 30 December 2020

OCA — Wed, 30 Dec 2020 07:36:10 GMT

←Older revision		Revision as of 07:36, 30 December 2020
Line 1:		Line 1:

	==Formyl-CoA transferase mutant Asp169 to Glu==		==Formyl-CoA transferase mutant Asp169 to Glu==
-	<StructureSection load='1vgr' size='340' side='right' caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1vgr' size='340' side='right'caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1VGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://pdbe.org/1vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://pdbe.org/1vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 40:		Line 40:
	[[Category: Atcc 35274]]		[[Category: Atcc 35274]]
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
		+	[[Category: Large Structures]]
	[[Category: Jonsson, S]]		[[Category: Jonsson, S]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]

OCA at 07:10, 4 April 2018

OCA — Wed, 04 Apr 2018 07:10:05 GMT

←Older revision		Revision as of 07:10, 4 April 2018
Line 1:		Line 1:
		+
	==Formyl-CoA transferase mutant Asp169 to Glu==		==Formyl-CoA transferase mutant Asp169 to Glu==
	<StructureSection load='1vgr' size='340' side='right' caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1vgr' size='340' side='right' caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://pdbe.org/1vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://pdbe.org/1vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:24, 8 February 2016

OCA — Mon, 08 Feb 2016 19:24:58 GMT

←Older revision		Revision as of 19:24, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:39, 10 September 2015

OCA — Thu, 10 Sep 2015 14:39:45 GMT

←Older revision		Revision as of 14:39, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1vgr' size='340' side='right' caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1vgr' size='340' side='right' caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oxalobacter_formigenes Oxalobacter formigenes~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VGR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ~~Oxalobacter formigenes~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://pdbe.org/1vgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vgr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 35274]]
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
-	[[Category: Oxalobacter formigenes]]
	[[Category: Jonsson, S]]		[[Category: Jonsson, S]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]

OCA at 01:37, 25 December 2014

OCA — Thu, 25 Dec 2014 01:37:37 GMT

←Older revision		Revision as of 01:37, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VGR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 Oxalobacter formigenes])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 Oxalobacter formigenes])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]
-	[[Category: Jonsson, S.]]	+	[[Category: Jonsson, S]]
-	[[Category: Lindqvist, Y.]]	+	[[Category: Lindqvist, Y]]
-	[[Category: Ricagno, S.]]	+	[[Category: Ricagno, S]]
-	[[Category: Richards, N G.]]	+	[[Category: Richards, N G]]
	[[Category: Caib-baif family]]		[[Category: Caib-baif family]]
	[[Category: Coa complex]]		[[Category: Coa complex]]

OCA at 21:14, 29 September 2014

OCA — Mon, 29 Sep 2014 21:14:56 GMT

←Older revision		Revision as of 21:14, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1vgr.~~png~~\|~~left~~\|200px]]	+	==Formyl-CoA transferase mutant Asp169 to Glu==
		+	<StructureSection load='1vgr' size='340' side='right' caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VGR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 Oxalobacter formigenes])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [http://www.ebi.ac.uk/pdbsum/1vgr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oxalobacter formigenes is an obligate anaerobe that colonizes the human gastrointestinal tract and employs oxalate breakdown to generate ATP in a novel process involving the interplay of two coupled enzymes and a membrane-bound oxalate:formate antiporter. Formyl-CoA transferase is a critical enzyme in oxalate-dependent ATP synthesis and is the first Class III CoA-transferase for which a high resolution, three-dimensional structure has been determined (Ricagno, S., Jonsson, S., Richards, N., and Lindqvist, Y. (2003) EMBO J. 22, 3210-3219). We now report the first detailed kinetic characterizations of recombinant, wild type formyl-CoA transferase and a number of site-specific mutants, which suggest that catalysis proceeds via a series of anhydride intermediates. Further evidence for this mechanistic proposal is provided by the x-ray crystallographic observation of an acylenzyme intermediate that is formed when formyl-CoA transferase is incubated with oxalyl-CoA. The catalytic mechanism of formyl-CoA transferase is therefore established and is almost certainly employed by all other members of the Class III CoA-transferase family.

-	~~{{STRUCTURE_1vgr\| PDB=1vgr \| SCENE= }}~~	+	Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes.,Jonsson S, Ricagno S, Lindqvist Y, Richards NG J Biol Chem. 2004 Aug 20;279(34):36003-12. Epub 2004 Jun 21. PMID:15213226<ref>PMID:15213226</ref>

-	~~===Formyl-CoA transferase mutant Asp169 to Glu===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_15213226}}~~	+	==See Also==
-		+	*[[Formyl-CoA transferase\|Formyl-CoA transferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1vgr~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015213226<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]

OCA: Protected "1vgr" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:20:52 GMT

Protected "1vgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 5 January 2013

OCA at 12:20, 5 January 2013

OCA — Sat, 05 Jan 2013 12:20:51 GMT

←Older revision		Revision as of 12:20, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1vgr.png\|left\|200px]]		[[Image:1vgr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vgr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vgr\| PDB=1vgr \| SCENE= }}		{{STRUCTURE_1vgr\| PDB=1vgr \| SCENE= }}

	===Formyl-CoA transferase mutant Asp169 to Glu===		===Formyl-CoA transferase mutant Asp169 to Glu===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15213226}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15213226 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15213226}}		{{ABSTRACT_PUBMED_15213226}}

	==About this Structure==		==About this Structure==
-	~~1VGR~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA].	+	[[1vgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15213226~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015213226</ref><references group="xtra"/>
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]
Line 37:		Line 25:
	[[Category: Oxalate]]		[[Category: Oxalate]]
	[[Category: Oxalate degradation]]		[[Category: Oxalate degradation]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 02:17:49 2009''~~	+

←Older revision		Revision as of 06:35, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1vgr' size='340' side='right'caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1vgr' size='340' side='right'caption='[[1vgr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1VGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1vgq\|1vgq]], [[1t3z\|1t3z]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FRC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=847 ATCC 35274])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [~~http~~://pdbe.org/1vgr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgr OCA], [https://pdbe.org/1vgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgr RCSB], [https://www.ebi.ac.uk/pdbsum/1vgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]	+	[[https://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]