1vl3 - Revision history

OCA at 06:31, 19 July 2023

OCA — Wed, 19 Jul 2023 06:31:21 GMT

←Older revision		Revision as of 06:31, 19 July 2023
Line 1:		Line 1:

	==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==		==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==
-	<StructureSection load='1vl3' size='340' side='right'caption='[[1vl3~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1vl3' size='340' side='right'caption='[[1vl3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [https://pdbe.org/1vl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [https://www.ebi.ac.uk/pdbsum/1vl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [https://pdbe.org/1vl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [https://www.ebi.ac.uk/pdbsum/1vl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl3 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coletta, M]]	+	[[Category: Coletta M]]
-	[[Category: Lombardi, A]]	+	[[Category: De Sanctis G]]
-	[[Category: Maglio, O]]	+	[[Category: Lombardi A]]
-	[[Category: Marasco, D]]	+	[[Category: Maglio O]]
-	[[Category: Nastri, F]]	+	[[Category: Marasco D]]
-	[[Category: Pavone, V]]	+	[[Category: Nastri F]]
-	~~[[Category: Sanctis, G De~~]]	+	[[Category: Pavone V]]
-	[[Category: Santucci, R]]	+	[[Category: Santucci R]]
-	[[Category: Sinibaldi, F]]	+	[[Category: Sinibaldi F]]
-	~~[[Category: Alpha-helix]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Design]]~~	+
-	~~[[Category: Miniaturized metalloprotein~~]]	+

OCA at 13:24, 13 October 2021

OCA — Wed, 13 Oct 2021 13:24:24 GMT

←Older revision		Revision as of 13:24, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='1vl3' size='340' side='right'caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1vl3' size='340' side='right'caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [~~http~~://pdbe.org/1vl3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vl3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [https://pdbe.org/1vl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [https://www.ebi.ac.uk/pdbsum/1vl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:31, 8 January 2020

OCA — Wed, 08 Jan 2020 10:31:14 GMT

←Older revision		Revision as of 10:31, 8 January 2020
Line 1:		Line 1:

	==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==		==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==
-	<StructureSection load='1vl3' size='340' side='right' caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1vl3' size='340' side='right'caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Coletta, M]]		[[Category: Coletta, M]]
	[[Category: Lombardi, A]]		[[Category: Lombardi, A]]

OCA at 07:36, 4 April 2018

OCA — Wed, 04 Apr 2018 07:36:17 GMT

←Older revision		Revision as of 07:36, 4 April 2018
Line 1:		Line 1:
		+
	==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==		==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==
	<StructureSection load='1vl3' size='340' side='right' caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1vl3' size='340' side='right' caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [http://pdbe.org/1vl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [http://www.ebi.ac.uk/pdbsum/1vl3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [http://pdbe.org/1vl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [http://www.ebi.ac.uk/pdbsum/1vl3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vl3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:45, 10 September 2015

OCA — Thu, 10 Sep 2015 22:45:38 GMT

←Older revision		Revision as of 22:45, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [http://www.ebi.ac.uk/pdbsum/1vl3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [http://pdbe.org/1vl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [http://www.ebi.ac.uk/pdbsum/1vl3 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vl3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:40, 22 December 2014

OCA — Mon, 22 Dec 2014 05:40:36 GMT

←Older revision		Revision as of 05:40, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1vl3\| PDB=1vl3 \| SCENE= }}~~	+	==DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY==
-	===DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY===	+	<StructureSection load='1vl3' size='340' side='right' caption='[[1vl3]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_14639648}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VL3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEU:CO(III)-(DEUTEROPORPHYRIN+IX)'>DEU</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vl3 RCSB], [http://www.ebi.ac.uk/pdbsum/1vl3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptide-based metalloprotein models represent useful systems to help understand how metalloproteins can support different functions, by the use of similar metal ion cofactors. In order to shed light on the role of the protein matrix in modulating the heme properties, we developed new models: mimochromes. They are pseudo-C(2) symmetric systems, composed of two helical peptides covalently linked to the deuteroporphyrin. The use of C(2) symmetry is particularly advantageous, because it simplifies the design, synthesis and characterization. However, it leaves the problem of possible diastereomeric forms. In the cobalt complex of the first derivative, mimochrome I, Lambda and Delta isomers were indeed experimentally observed. All the insights derived from the Co(III)-mimochrome I structure were used to obtain a re-designed molecule, mimochrome IV. The spectroscopic characterization of the iron and cobalt derivatives suggested the presence of the Lambda isomer as unique species. The NMR solution structure of the diamagnetic Co(III)-mimochrome IV confirmed the ability of the molecule to adopt a unique topology, and revealed the peptide chains to be in helical conformation, as designed. The insertion of intramolecular, inter-chain interactions was successful in favoring the formation of one of the two possible diastereomers. The stereochemically stable structure of mimochrome IV provides an attractive model for modulating the redox potential of the heme, by simple changing the peptide chain composition around the heme.

-	~~==About this Structure==~~	+	Design of a new mimochrome with unique topology.,Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V Chemistry. 2003 Nov 21;9(22):5643-54. PMID:14639648<ref>PMID:14639648</ref>
-	~~[[1vl3]] is~~ a ~~2 chain structure~~. ~~This structure supersedes the now removed PDB entry [http~~:~~//oca.weizmann.ac.il/oca~~-~~bin/send-pdb?obs=1&id=1l1b 1l1b]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:014639648</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Coletta, M.]]	+	== References ==
-	[[Category: Lombardi, A.]]	+	<references/>
-	[[Category: Maglio, O.]]	+	__TOC__
-	[[Category: Marasco, D.]]	+	</StructureSection>
-	[[Category: Nastri, F.]]	+	[[Category: Coletta, M]]
-	[[Category: Pavone, V.]]	+	[[Category: Lombardi, A]]
-	[[Category: Sanctis, G De.]]	+	[[Category: Maglio, O]]
-	[[Category: Santucci, R.]]	+	[[Category: Marasco, D]]
-	[[Category: Sinibaldi, F.]]	+	[[Category: Nastri, F]]
		+	[[Category: Pavone, V]]
		+	[[Category: Sanctis, G De]]
		+	[[Category: Santucci, R]]
		+	[[Category: Sinibaldi, F]]
	[[Category: Alpha-helix]]		[[Category: Alpha-helix]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Design]]		[[Category: Design]]
	[[Category: Miniaturized metalloprotein]]		[[Category: Miniaturized metalloprotein]]

OCA at 08:20, 23 April 2014

OCA — Wed, 23 Apr 2014 08:20:54 GMT

←Older revision		Revision as of 08:20, 23 April 2014
Line 1:		Line 1:
-	[[Image:1vl3.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vl3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vl3\| PDB=1vl3 \| SCENE= }}		{{STRUCTURE_1vl3\| PDB=1vl3 \| SCENE= }}
-
	===DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY===		===DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14639648}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14639648 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14639648}}		{{ABSTRACT_PUBMED_14639648}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:014639648</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014639648</ref><references group="xtra"/><references/>
	[[Category: Coletta, M.]]		[[Category: Coletta, M.]]
	[[Category: Lombardi, A.]]		[[Category: Lombardi, A.]]

OCA: Protected "1vl3" [edit=sysop:move=sysop]

OCA — Wed, 31 Aug 2011 05:55:56 GMT

Protected "1vl3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:55, 31 August 2011

OCA at 05:55, 31 August 2011

OCA — Wed, 31 Aug 2011 05:55:54 GMT

←Older revision		Revision as of 05:55, 31 August 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1vl3.png\|left\|200px]]		[[Image:1vl3.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].	+	[[1vl3]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].

	==Reference==		==Reference==
-	~~Design of a new mimochrome with unique topology., Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V, Chemistry. 2003 Nov 21;9(22):5643-54.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~14639648 14639648]~~	+	<ref group="xtra">PMID:014639648</ref><references group="xtra"/>
	[[Category: Coletta, M.]]		[[Category: Coletta, M.]]
	[[Category: Lombardi, A.]]		[[Category: Lombardi, A.]]
Line 34:		Line 33:
	[[Category: Sinibaldi, F.]]		[[Category: Sinibaldi, F.]]
	[[Category: Alpha-helix]]		[[Category: Alpha-helix]]
		+	[[Category: De novo protein]]
	[[Category: Design]]		[[Category: Design]]
	[[Category: Miniaturized metalloprotein]]		[[Category: Miniaturized metalloprotein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:57:56 2008''

OCA at 10:57, 28 July 2008

OCA — Mon, 28 Jul 2008 10:57:57 GMT

←Older revision		Revision as of 10:57, 28 July 2008
Line 1:		Line 1:
-	[[Image:1vl3.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1vl3.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1vl3\| PDB=1vl3 \| SCENE= }}		{{STRUCTURE_1vl3\| PDB=1vl3 \| SCENE= }}

-	~~'''~~DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY~~'''~~	+	===DESIGN OF NEW MIMOCHROMES WITH UNIQUE TOPOLOGY===


-	~~==Overview==~~	+	<!--
-	~~Peptide~~-based metalloprotein models represent useful systems to help understand how metalloproteins can support different functions, by the use of similar metal ion cofactors. In order to shed light on the role of the protein matrix in modulating the heme properties, we developed new models: mimochromes. They are pseudo-~~C(2) symmetric systems, composed of two helical peptides covalently linked to the deuteroporphyrin.~~ The ~~use of C(2) symmetry is particularly advantageous~~, ~~because it simplifies the design~~, ~~synthesis and characterization. However, it leaves~~ the ~~problem of possible diastereomeric forms. In~~ the ~~cobalt complex of the first derivative, mimochrome I, Lambda and Delta isomers were indeed experimentally observed. All the insights derived from the Co~~(~~III)-mimochrome I structure were used to obtain a re-designed molecule, mimochrome IV. The spectroscopic characterization of the iron and cobalt derivatives suggested the presence of the Lambda isomer~~ as ~~unique species~~. ~~The NMR solution structure of the diamagnetic Co(III~~)~~-mimochrome IV confirmed the ability of the molecule to adopt a unique topology~~, ~~and revealed~~ the ~~peptide chains to be in helical conformation, as designed~~. ~~The insertion of intramolecular, inter~~-chain interactions was successful in favoring the formation of one of the two possible diastereomers. The stereochemically stable structure of mimochrome IV provides an attractive model for modulating the redox potential of the heme, by simple changing the peptide chain composition around the heme.	+	The line below this paragraph, {{ABSTRACT_PUBMED_14639648}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 14639648 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_14639648}}

	==About this Structure==		==About this Structure==
-	This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].	+	This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l1b 1l1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VL3 OCA].

	==Reference==		==Reference==
Line 32:		Line 36:
	[[Category: Design]]		[[Category: Design]]
	[[Category: Miniaturized metalloprotein]]		[[Category: Miniaturized metalloprotein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:40:04 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:57:56 2008''