1vot - Revision history

Eric Martz: Added languages

Eric Martz — Fri, 16 Jun 2017 17:28:51 GMT

Added languages

←Older revision		Revision as of 17:28, 16 June 2017
Line 39:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[en:1vot]]
		+	[[zh:1vot (Chinese)]]
		+
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]

OCA at 05:41, 8 February 2016

OCA — Mon, 08 Feb 2016 05:41:26 GMT

←Older revision		Revision as of 05:41, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vot ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 34:
	*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]		*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]
	*[[PDB identification code\|PDB identification code]]		*[[PDB identification code\|PDB identification code]]
		+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:27, 10 September 2015

OCA — Thu, 10 Sep 2015 08:27:42 GMT

←Older revision		Revision as of 08:27, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HUP:HUPERZINE+A'>HUP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HUP:HUPERZINE+A'>HUP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vot RCSB], [http://www.ebi.ac.uk/pdbsum/1vot PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vot OCA], [http://pdbe.org/1vot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vot RCSB], [http://www.ebi.ac.uk/pdbsum/1vot PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vot" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]		*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]
-	*[[AChE inhibitors and substrates (Part II)\|AChE inhibitors and substrates (Part II)]]
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
	*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]		*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]

OCA at 21:02, 24 December 2014

OCA — Wed, 24 Dec 2014 21:02:48 GMT

←Older revision		Revision as of 21:02, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VOT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VOT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HUP:HUPERZINE+A'>HUP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HUP:HUPERZINE+A'>HUP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vot RCSB], [http://www.ebi.ac.uk/pdbsum/1vot PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vot RCSB], [http://www.ebi.ac.uk/pdbsum/1vot PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 40:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]
-	[[Category: Harel, M.]]	+	[[Category: Harel, M]]
-	[[Category: Raves, M L.]]	+	[[Category: Raves, M L]]
-	[[Category: Silman, I.]]	+	[[Category: Silman, I]]
-	[[Category: Sussman, J L.]]	+	[[Category: Sussman, J L]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Neurotransmitter cleavage]]		[[Category: Neurotransmitter cleavage]]

OCA at 05:19, 3 October 2014

OCA — Fri, 03 Oct 2014 05:19:20 GMT

←Older revision		Revision as of 05:19, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1vot\| PDB=1vot \| SCENE= }}~~	+	==ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A==
-	===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===	+	<StructureSection load='1vot' size='340' side='right' caption='[[1vot]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_8989325}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VOT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HUP:HUPERZINE+A'>HUP</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vot RCSB], [http://www.ebi.ac.uk/pdbsum/1vot PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/1vot_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	(-)-Huperzine A (HupA) is found in an extract from a club moss that has been used for centuries in Chinese folk medicine. Its action has been attributed to its ability to strongly inhibit acetylcholinesterase (AChE). The crystal structure of the complex of AChE with optically pure HupA at 2.5 A resolution shows an unexpected orientation for the inhibitor with surprisingly few strong direct interactions with protein residues to explain its high affinity. This structure is compared to the native structure of AChE devoid of any inhibitor as determined to the same resolution. An analysis of the affinities of structural analogues of HupA, correlated with their interactions with the protein, shows the importance of individual hydrophobic interactions between HupA and aromatic residues in the active-site gorge of AChE.

-	~~==Function==~~	+	Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.,Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL Nat Struct Biol. 1997 Jan;4(1):57-63. PMID:8989325<ref>PMID:8989325</ref>
-	~~[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis~~ of the ~~acetylcholine released into the synaptic cleft~~. ~~May be involved in cell~~-~~cell interactions~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1vot]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Torpedo_californica Torpedo californica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1VOT OCA].~~	+	</div>

	==See Also==		==See Also==
Line 15:		Line 32:
	*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]		*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]
	*[[PDB identification code\|PDB identification code]]		*[[PDB identification code\|PDB identification code]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:008989325</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]

OCA at 05:27, 23 October 2013

OCA — Wed, 23 Oct 2013 05:27:08 GMT

←Older revision		Revision as of 05:27, 23 October 2013
Line 2:		Line 2:
	===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===		===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===
	{{ABSTRACT_PUBMED_8989325}}		{{ABSTRACT_PUBMED_8989325}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.

	==About this Structure==		==About this Structure==
Line 11:		Line 14:
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
	*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]		*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]
		+	*[[PDB identification code\|PDB identification code]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008989325</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008989325</ref><references group="xtra"/><references/>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]

OCA at 10:19, 11 March 2013

OCA — Mon, 11 Mar 2013 10:19:35 GMT

←Older revision		Revision as of 10:19, 11 March 2013
Line 1:		Line 1:
-	[[Image:1vot.png\|left\|200px]]
-
	{{STRUCTURE_1vot\| PDB=1vot \| SCENE= }}		{{STRUCTURE_1vot\| PDB=1vot \| SCENE= }}
-
	===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===		===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===
-
	{{ABSTRACT_PUBMED_8989325}}		{{ABSTRACT_PUBMED_8989325}}

OCA at 09:06, 20 October 2012

OCA — Sat, 20 Oct 2012 09:06:34 GMT

←Older revision		Revision as of 09:06, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1vot]] is a 1 chain structure ~~of [[Acetylcholinesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOT OCA].	+	[[1vot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOT OCA].

	==See Also==		==See Also==

OCA at 21:47, 25 July 2012

OCA — Wed, 25 Jul 2012 21:47:09 GMT

←Older revision		Revision as of 21:47, 25 July 2012
Line 1:		Line 1:
	[[Image:1vot.png\|left\|200px]]		[[Image:1vot.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vot", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vot\| PDB=1vot \| SCENE= }}		{{STRUCTURE_1vot\| PDB=1vot \| SCENE= }}

	===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===		===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8989325}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8989325 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8989325}}		{{ABSTRACT_PUBMED_8989325}}

Line 25:		Line 14:
	*[[AChE inhibitors and substrates (Part II)\|AChE inhibitors and substrates (Part II)]]		*[[AChE inhibitors and substrates (Part II)\|AChE inhibitors and substrates (Part II)]]
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
-	*[[Alzheimer's Disease\|Alzheimer's Disease]]
	*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]		*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]

OCA at 07:15, 13 June 2012

OCA — Wed, 13 Jun 2012 07:15:48 GMT

←Older revision		Revision as of 07:15, 13 June 2012
Line 26:		Line 26:
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
	*[[Alzheimer's Disease\|Alzheimer's Disease]]		*[[Alzheimer's Disease\|Alzheimer's Disease]]
		+	*[[Huperzine A Complexed with Acetylcholinesterase\|Huperzine A Complexed with Acetylcholinesterase]]

	==Reference==		==Reference==