1vqc - Revision history

OCA at 08:46, 14 February 2024

OCA — Wed, 14 Feb 2024 08:46:51 GMT

←Older revision		Revision as of 08:46, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1vqc' size='340' side='right'caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vqc' size='340' side='right'caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bpf1 Bpf1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_f1 Enterobacteria phage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [https://pdbe.org/1vqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [https://www.ebi.ac.uk/pdbsum/1vqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqc ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [https://pdbe.org/1vqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [https://www.ebi.ac.uk/pdbsum/1vqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/G5P_BPF1 G5P_BPF1]] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).	+	[https://www.uniprot.org/uniprot/G5P_BPF1 G5P_BPF1] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vqc ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.
-
-	Potential use of additivity of mutational effects in simplifying protein engineering.,Skinner MM, Terwilliger TC Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10753-7. PMID:8855252<ref>PMID:8855252</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1vqc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Single-stranded DNA-binding protein 3D structures\|Single-stranded DNA-binding protein 3D structures]]		*[[Single-stranded DNA-binding protein 3D structures\|Single-stranded DNA-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bpf1~~]]	+	[[Category: Enterobacteria phage f1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Skinner~~, M M~~]]	+	[[Category: Skinner MM]]
-	[[Category: Terwilliger~~, T C]]~~	+	[[Category: Terwilliger TC]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Gene v]]~~	+
-	~~[[Category: Mutant~~]]	+

OCA at 15:33, 3 November 2021

OCA — Wed, 03 Nov 2021 15:33:12 GMT

←Older revision		Revision as of 15:33, 3 November 2021
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	[[Category: Skinner, M M]]		[[Category: Skinner, M M]]
	[[Category: Terwilliger, T C]]		[[Category: Terwilliger, T C]]
		+	[[Category: Dna binding protein]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Gene v]]		[[Category: Gene v]]
	[[Category: Mutant]]		[[Category: Mutant]]

OCA at 13:25, 13 October 2021

OCA — Wed, 13 Oct 2021 13:25:52 GMT

←Older revision		Revision as of 13:25, 13 October 2021
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	<StructureSection load='1vqc' size='340' side='right'caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vqc' size='340' side='right'caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [~~http~~://pdbe.org/1vqc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vqc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqc ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [https://pdbe.org/1vqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [https://www.ebi.ac.uk/pdbsum/1vqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/G5P_BPF1 G5P_BPF1]] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).	+	[[https://www.uniprot.org/uniprot/G5P_BPF1 G5P_BPF1]] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Single-stranded DNA-binding protein\|Single-stranded DNA-binding protein]]	+	*[[Single-stranded DNA-binding protein 3D structures\|Single-stranded DNA-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:46, 8 January 2020

OCA — Wed, 08 Jan 2020 10:46:15 GMT

←Older revision		Revision as of 10:46, 8 January 2020
Line 1:		Line 1:

	==GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)==		==GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)==
-	<StructureSection load='1vqc' size='340' side='right' caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1vqc' size='340' side='right'caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bpf1]]		[[Category: Bpf1]]
		+	[[Category: Large Structures]]
	[[Category: Skinner, M M]]		[[Category: Skinner, M M]]
	[[Category: Terwilliger, T C]]		[[Category: Terwilliger, T C]]

OCA at 07:48, 4 April 2018

OCA — Wed, 04 Apr 2018 07:48:53 GMT

←Older revision		Revision as of 07:48, 4 April 2018
Line 1:		Line 1:
		+
	==GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)==		==GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)==
	<StructureSection load='1vqc' size='340' side='right' caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vqc' size='340' side='right' caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://pdbe.org/1vqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://pdbe.org/1vqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/1vqc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/1vqc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:06, 10 February 2016

OCA — Wed, 10 Feb 2016 07:06:20 GMT

←Older revision		Revision as of 07:06, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:32, 11 September 2015

OCA — Fri, 11 Sep 2015 06:32:14 GMT

←Older revision		Revision as of 06:32, 11 September 2015
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	<StructureSection load='1vqc' size='340' side='right' caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vqc' size='340' side='right' caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_f1 Enterobacteria phage f1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpf1 Bpf1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://pdbe.org/1vqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~VHED_BPF1 VHED_BPF1~~]] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).	+	[[http://www.uniprot.org/uniprot/G5P_BPF1 G5P_BPF1]] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vqc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage f1~~]]	+	[[Category: Bpf1]]
	[[Category: Skinner, M M]]		[[Category: Skinner, M M]]
	[[Category: Terwilliger, T C]]		[[Category: Terwilliger, T C]]

OCA at 12:37, 25 December 2014

OCA — Thu, 25 Dec 2014 12:37:50 GMT

←Older revision		Revision as of 12:37, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_f1 Enterobacteria phage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_f1 Enterobacteria phage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VHED_BPF1 VHED_BPF1]] Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single-stranded (progeny) viral DNA, prevents the conversion into the double-stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Enterobacteria phage f1]]		[[Category: Enterobacteria phage f1]]
-	[[Category: Skinner, M M.]]	+	[[Category: Skinner, M M]]
-	[[Category: Terwilliger, T C.]]	+	[[Category: Terwilliger, T C]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Gene v]]		[[Category: Gene v]]
	[[Category: Mutant]]		[[Category: Mutant]]

OCA at 19:45, 29 September 2014

OCA — Mon, 29 Sep 2014 19:45:46 GMT

←Older revision		Revision as of 19:45, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1vqc.~~png\|left~~\|200px]]	+	==GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)==
		+	<StructureSection load='1vqc' size='340' side='right' caption='[[1vqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_f1 Enterobacteria phage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VQC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vqc RCSB], [http://www.ebi.ac.uk/pdbsum/1vqc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/1vqc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.

-	~~{{STRUCTURE_1vqc\| PDB=1vqc \| SCENE= }}~~	+	Potential use of additivity of mutational effects in simplifying protein engineering.,Skinner MM, Terwilliger TC Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10753-7. PMID:8855252<ref>PMID:8855252</ref>

-	~~===GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I~~, ~~I47F)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_8855252}}~~	+	==See Also==
-		+	*[[Single-stranded DNA-binding protein\|Single-stranded DNA-binding protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1vqc~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_f1 Enterobacteria phage f1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQC OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:008855252<~~/~~ref~~><~~ref group="xtra">PMID:015048824</ref><references group="xtra"~~/>	+
	[[Category: Enterobacteria phage f1]]		[[Category: Enterobacteria phage f1]]
	[[Category: Skinner, M M.]]		[[Category: Skinner, M M.]]

OCA: Protected "1vqc" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:02:53 GMT

Protected "1vqc" [edit=sysop:move=sysop]

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Revision as of 13:02, 5 January 2013