1vwe - Revision history

OCA at 13:26, 9 May 2024

OCA — Thu, 09 May 2024 13:26:56 GMT

←Older revision		Revision as of 13:26, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1vwe' size='340' side='right'caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1vwe' size='340' side='right'caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~As_4.1583 As 4.1583~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [https://pdbe.org/1vwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [https://www.ebi.ac.uk/pdbsum/1vwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vwe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [https://pdbe.org/1vwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [https://www.ebi.ac.uk/pdbsum/1vwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vwe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).	+	[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: As 4 1583]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cass, R T~~]]	+	[[Category: Streptomyces avidinii]]
-	[[Category: ~~Katz, B A~~]]	+	[[Category: Cass RT]]
-	[[Category: ~~Cyclic peptide discovered by phage display~~]]	+	[[Category: Katz BA]]

OCA at 13:27, 13 October 2021

OCA — Wed, 13 Oct 2021 13:27:47 GMT

←Older revision		Revision as of 13:27, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='1vwe' size='340' side='right'caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1vwe' size='340' side='right'caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [~~http~~://pdbe.org/1vwe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vwe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vwe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [https://pdbe.org/1vwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [https://www.ebi.ac.uk/pdbsum/1vwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vwe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).	+	[[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:02, 8 January 2020

OCA — Wed, 08 Jan 2020 10:02:47 GMT

←Older revision		Revision as of 10:02, 8 January 2020
Line 1:		Line 1:

	==STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6==		==STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6==
-	<StructureSection load='1vwe' size='340' side='right' caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1vwe' size='340' side='right'caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Avidin\|Avidin]]	+	*[[Avidin 3D structures\|Avidin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: As 4 1583]]		[[Category: As 4 1583]]
		+	[[Category: Large Structures]]
	[[Category: Cass, R T]]		[[Category: Cass, R T]]
	[[Category: Katz, B A]]		[[Category: Katz, B A]]
	[[Category: Cyclic peptide discovered by phage display]]		[[Category: Cyclic peptide discovered by phage display]]

OCA at 07:10, 4 April 2018

OCA — Wed, 04 Apr 2018 07:10:15 GMT

←Older revision		Revision as of 07:10, 4 April 2018
Line 1:		Line 1:
		+
	==STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6==		==STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6==
	<StructureSection load='1vwe' size='340' side='right' caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1vwe' size='340' side='right' caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://pdbe.org/1vwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://pdbe.org/1vwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vwe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/1vwe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/1vwe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vwe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:58, 11 September 2015

OCA — Fri, 11 Sep 2015 14:58:55 GMT

←Older revision		Revision as of 14:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1vwe' size='340' side='right' caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1vwe' size='340' side='right' caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_avidinii Streptomyces avidinii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://pdbe.org/1vwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vwe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptomyces avidinii~~]]	+	[[Category: As 4 1583]]
	[[Category: Cass, R T]]		[[Category: Cass, R T]]
	[[Category: Katz, B A]]		[[Category: Katz, B A]]
	[[Category: Cyclic peptide discovered by phage display]]		[[Category: Cyclic peptide discovered by phage display]]

OCA at 18:03, 25 December 2014

OCA — Thu, 25 Dec 2014 18:03:20 GMT

←Older revision		Revision as of 18:03, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Streptomyces avidinii]]		[[Category: Streptomyces avidinii]]
-	[[Category: Cass, R T.]]	+	[[Category: Cass, R T]]
-	[[Category: Katz, B A.]]	+	[[Category: Katz, B A]]
	[[Category: Cyclic peptide discovered by phage display]]		[[Category: Cyclic peptide discovered by phage display]]

OCA at 23:10, 28 September 2014

OCA — Sun, 28 Sep 2014 23:10:08 GMT

←Older revision		Revision as of 23:10, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1vwe.~~png\|left~~\|200px]]	+	==STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6==
		+	<StructureSection load='1vwe' size='340' side='right' caption='[[1vwe]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VWE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vwe RCSB], [http://www.ebi.ac.uk/pdbsum/1vwe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/1vwe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The pH dependences of the affinities for streptavidin of linear and cyclic peptide ligands containing the HPQ sequence discovered by phage display were determined by plasmon resonance measurements. At pH values ranging from 3.0 to 9.0, the Kd values for Ac-AEFSHPQNTIEGRK-NH2, cyclo-Ac-AE[CHPQGPPC]IEGRK-NH2, and cyclo-Ac-AE[CHPQFC]IEGRK-NH2, were determined by competition, and those for cyclo-[5-S-valeramide-HPQGPPC]K-NH2 were determined directly by equilibrium affinity measurements. The Kd values of the ligands increase by an average factor of 3.0 +/- 0.8 per decrease in pH unit between pH approximately 4.5 and pH approximately 6.3. Below pH approximately 4.5 there is a smaller increase in Kd values, and above pH approximately 6.3 the Kd values become relatively pH-independent. We determined the crystal structures of complexes of streptavidin with cyclo-[5-S-valeramide-HPQGPPC]K-NH2 at pH 1.5, 2.5, 3.0, and 3.5, with cyclo-Ac-[CHPQFC]-NH2 at pH 2.0, 3.0, 3.6, 4.2, 4.8, and 11.8, with cyclo-Ac-[CHPQGPPC]-NH2 at pH 2.5, 2.9, and 3.7, and with FSHPQNT at pH 4.0 and compared the structures with one another and with those previously determined at other pH values. At pH values from 3.0 to 11.8, the electron density for the peptide His side chain is strong, flat, and well defined. A hydrogen bond between the Ndelta1 atom of the His and the peptide Gln amide group indicates the His of the bound peptide in the crystals is uncharged at pH >/= 3.0. By determining selected structures in two different space groups, I222 with two crystallographically inequivalent ligand sites and I4122 with one site, we show that below pH approximately 3.0, the pKa of the bound peptide His in the crystals is influenced by crystal packing interactions. The presence of the Ndelta1His-NGln hydrogen bond along with pH dependences of the peptide affinities suggest that deprotonation of the peptide His is required for high affinity binding of HPQ-containing peptides to streptavidin both in the crystals and in solution.

-	~~{{STRUCTURE_1vwe\| PDB=1vwe \| SCENE= }}~~	+	In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.,Katz BA, Cass RT J Biol Chem. 1997 May 16;272(20):13220-8. PMID:9148939<ref>PMID:9148939</ref>

-	~~===STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2~~, ~~PH 3.6===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9148939}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1vwe]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_avidinii Streptomyces avidinii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA].~~	+

	==See Also==		==See Also==
	*[[Avidin\|Avidin]]		*[[Avidin\|Avidin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009148939<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Streptomyces avidinii]]		[[Category: Streptomyces avidinii]]
	[[Category: Cass, R T.]]		[[Category: Cass, R T.]]
	[[Category: Katz, B A.]]		[[Category: Katz, B A.]]
	[[Category: Cyclic peptide discovered by phage display]]		[[Category: Cyclic peptide discovered by phage display]]

OCA at 19:45, 20 October 2012

OCA — Sat, 20 Oct 2012 19:45:35 GMT

←Older revision		Revision as of 19:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1vwe]] is a 2 chain structure ~~of [[Avidin]]~~ with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA].	+	[[1vwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VWE OCA].

	==See Also==		==See Also==

OCA at 08:22, 27 July 2012

OCA — Fri, 27 Jul 2012 08:22:52 GMT

←Older revision		Revision as of 08:22, 27 July 2012
Line 1:		Line 1:
	[[Image:1vwe.png\|left\|200px]]		[[Image:1vwe.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vwe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vwe\| PDB=1vwe \| SCENE= }}		{{STRUCTURE_1vwe\| PDB=1vwe \| SCENE= }}

	===STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6===		===STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 3.6===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9148939}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9148939 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9148939}}		{{ABSTRACT_PUBMED_9148939}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Avidin]]	+	*[[Avidin\|Avidin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9148939~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009148939</ref><references group="xtra"/>
	[[Category: Streptomyces avidinii]]		[[Category: Streptomyces avidinii]]
	[[Category: Cass, R T.]]		[[Category: Cass, R T.]]
	[[Category: Katz, B A.]]		[[Category: Katz, B A.]]
	[[Category: Cyclic peptide discovered by phage display]]		[[Category: Cyclic peptide discovered by phage display]]

OCA: Protected "1vwe" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 02:09:33 GMT

Protected "1vwe" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:09, 27 December 2010