1vys - Revision history

OCA at 13:08, 13 December 2023

OCA — Wed, 13 Dec 2023 13:08:44 GMT

←Older revision		Revision as of 13:08, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1vys' size='340' side='right'caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vys' size='340' side='right'caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter~~ cloacae~~" (jordan 1890) bergey et al. 1923~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1VYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>~~, ~~<scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[1gvo\|1gvo]]~~, ~~[[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [~~http~~://pdbe.org/1vys PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vys PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vys ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [https://pdbe.org/1vys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [https://www.ebi.ac.uk/pdbsum/1vys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vys ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P71278_ENTCL P71278_ENTCL]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Enterobacter cloacae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barna, T]]	+	[[Category: Barna T]]
-	[[Category: Moody~~, P C.E]]~~	+	[[Category: Moody PCE]]
-	~~[[Category: Explosive degradation]]~~	+
-	~~[[Category: Flavoenzyme]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Steroid binding~~]]	+

OCA at 11:49, 29 July 2020

OCA — Wed, 29 Jul 2020 11:49:47 GMT

←Older revision		Revision as of 11:49, 29 July 2020
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	==STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID==		==STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID==
-	<StructureSection load='1vys' size='340' side='right' caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1vys' size='340' side='right'caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1VYS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://pdbe.org/1vys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vys ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://pdbe.org/1vys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vys ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barna, T]]		[[Category: Barna, T]]
	[[Category: Moody, P C.E]]		[[Category: Moody, P C.E]]

OCA at 07:31, 4 April 2018

OCA — Wed, 04 Apr 2018 07:31:45 GMT

←Older revision		Revision as of 07:31, 4 April 2018
Line 1:		Line 1:
		+
	==STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID==		==STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID==
	<StructureSection load='1vys' size='340' side='right' caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vys' size='340' side='right' caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://pdbe.org/1vys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://pdbe.org/1vys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vys ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vys_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vys_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:50, 8 February 2016

OCA — Mon, 08 Feb 2016 16:50:51 GMT

←Older revision		Revision as of 16:50, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vys ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:33, 10 September 2015

OCA — Thu, 10 Sep 2015 13:33:41 GMT

←Older revision		Revision as of 13:33, 10 September 2015
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	<StructureSection load='1vys' size='340' side='right' caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1vys' size='340' side='right' caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacter_cloacae Enterobacter~~ cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://pdbe.org/1vys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vys" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Enterobacter cloacae]]
	[[Category: Barna, T]]		[[Category: Barna, T]]
	[[Category: Moody, P C.E]]		[[Category: Moody, P C.E]]

OCA at 12:45, 6 January 2015

OCA — Tue, 06 Jan 2015 12:45:57 GMT

←Older revision		Revision as of 12:45, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Enterobacter cloacae]]		[[Category: Enterobacter cloacae]]
-	[[Category: Barna, T.]]	+	[[Category: Barna, T]]
-	[[Category: Moody, P C.E.]]	+	[[Category: Moody, P C.E]]
	[[Category: Explosive degradation]]		[[Category: Explosive degradation]]
	[[Category: Flavoenzyme]]		[[Category: Flavoenzyme]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Steroid binding]]		[[Category: Steroid binding]]

OCA at 04:17, 3 October 2014

OCA — Fri, 03 Oct 2014 04:17:03 GMT

←Older revision		Revision as of 04:17, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1vys\| PDB=1vys \| SCENE= }}~~	+	==STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID==
-	===STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID===	+	<StructureSection load='1vys' size='340' side='right' caption='[[1vys]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15128738}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=TNF:PICRIC+ACID'>TNF</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gvo\|1gvo]], [[1gvq\|1gvq]], [[1gvr\|1gvr]], [[1gvs\|1gvs]], [[1h50\|1h50]], [[1h51\|1h51]], [[1h60\|1h60]], [[1h61\|1h61]], [[1h62\|1h62]], [[1h63\|1h63]], [[1vyp\|1vyp]], [[1vyr\|1vyr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vys RCSB], [http://www.ebi.ac.uk/pdbsum/1vys PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vys_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of pentaerythritol tetranitrate (PETN) reductase in complex with the nitroaromatic substrate picric acid determined previously at 1.55 A resolution indicated additional electron density between the indole ring of residue Trp-102 and the nitro group at C-6 of picrate. The data suggested the presence of an unusual bond between substrate and the tryptophan side chain. Herein, we have extended the resolution of the PETN reductase-picric acid complex to 0.9 A. This high-resolution analysis indicates that the active site is partially occupied with picric acid and that the anomalous density seen in the original study is attributed to the population of multiple conformational states of Trp-102 and not a formal covalent bond between the indole ring of Trp-102 and picric acid. The significance of any interaction between Trp-102 and nitroaromatic substrates was probed further in solution and crystal complexes with wild-type and mutant (W102Y and W102F) enzymes. Unlike with wild-type enzyme, in the crystalline form picric acid was bound at full occupancy in the mutant enzymes, and there was no evidence for multiple conformations of active site residues. Solution studies indicate tighter binding of picric acid in the active sites of the W102Y and W102F enzymes. Mutation of Trp-102 does not impair significantly enzyme reduction by NADPH, but the kinetics of decay of the hydride-Meisenheimer complex are accelerated in the mutant enzymes. The data reveal that decay of the hydride-Meisenheimer complex is enzyme catalyzed and that the final distribution of reaction products for the mutant enzymes is substantially different from wild-type enzyme. Implications for the mechanism of high explosive degradation by PETN reductase are discussed.

-	~~==About this Structure==~~	+	Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase. Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation.,Khan H, Barna T, Harris RJ, Bruce NC, Barsukov I, Munro AW, Moody PC, Scrutton NS J Biol Chem. 2004 Jul 16;279(29):30563-72. Epub 2004 May 5. PMID:15128738<ref>PMID:15128738</ref>
-	~~[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae~~ Enterobacter cloacae]. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1VYS OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Pentaerythritol tetranitrate reductase\|Pentaerythritol tetranitrate reductase]]		*[[Pentaerythritol tetranitrate reductase\|Pentaerythritol tetranitrate reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015128738</ref><ref group="xtra">PMID:011428899</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacter cloacae]]		[[Category: Enterobacter cloacae]]
	[[Category: Barna, T.]]		[[Category: Barna, T.]]

OCA at 09:33, 24 April 2013

OCA — Wed, 24 Apr 2013 09:33:36 GMT

←Older revision		Revision as of 09:33, 24 April 2013
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	{{STRUCTURE_1vys\| PDB=1vys \| SCENE= }}		{{STRUCTURE_1vys\| PDB=1vys \| SCENE= }}
-	===~~STUCTURE~~ OF PENTAERYTHRITOL ~~TETRANIRATE~~ REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID===	+	===STRUCTURE OF PENTAERYTHRITOL TETRANITRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID===
	{{ABSTRACT_PUBMED_15128738}}		{{ABSTRACT_PUBMED_15128738}}

Line 10:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015128738</ref><ref group="xtra">PMID:011428899</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015128738</ref><ref group="xtra">PMID:011428899</ref><references group="xtra"/><references/>
	[[Category: Enterobacter cloacae]]		[[Category: Enterobacter cloacae]]
	[[Category: Barna, T.]]		[[Category: Barna, T.]]
Line 16:		Line 16:
	[[Category: Explosive degradation]]		[[Category: Explosive degradation]]
	[[Category: Flavoenzyme]]		[[Category: Flavoenzyme]]
-	[[Category: ~~Reductase~~]]	+	[[Category: Oxidoreductase]]
	[[Category: Steroid binding]]		[[Category: Steroid binding]]

OCA at 09:22, 11 March 2013

OCA — Mon, 11 Mar 2013 09:22:10 GMT

←Older revision		Revision as of 09:22, 11 March 2013
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-	[[Image:1vys.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vys", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vys\| PDB=1vys \| SCENE= }}		{{STRUCTURE_1vys\| PDB=1vys \| SCENE= }}
-
	===STUCTURE OF PENTAERYTHRITOL TETRANIRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID===		===STUCTURE OF PENTAERYTHRITOL TETRANIRATE REDUCTASE W102Y MUTANT AND COMPLEXED WITH PICRIC ACID===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15128738}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15128738 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15128738}}		{{ABSTRACT_PUBMED_15128738}}

OCA at 08:01, 25 April 2012

OCA — Wed, 25 Apr 2012 08:01:01 GMT

←Older revision		Revision as of 08:01, 25 April 2012
Line 20:		Line 20:
	==About this Structure==		==About this Structure==
	[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA].		[[1vys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYS OCA].
		+
		+	==See Also==
		+	*[[Pentaerythritol tetranitrate reductase\|Pentaerythritol tetranitrate reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15128738~~</ref><ref group="xtra">PMID:~~11428899~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015128738</ref><ref group="xtra">PMID:011428899</ref><references group="xtra"/>
	[[Category: Enterobacter cloacae]]		[[Category: Enterobacter cloacae]]
	[[Category: Barna, T.]]		[[Category: Barna, T.]]