1vyu - Revision history

OCA at 13:27, 9 May 2024

OCA — Thu, 09 May 2024 13:27:49 GMT

←Older revision		Revision as of 13:27, 9 May 2024
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	<StructureSection load='1vyu' size='340' side='right'caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1vyu' size='340' side='right'caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYU FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1vyt\|1vyt]], [[1vyv\|1vyv]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [https://pdbe.org/1vyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [https://www.ebi.ac.uk/pdbsum/1vyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [https://pdbe.org/1vyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [https://www.ebi.ac.uk/pdbsum/1vyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT]] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.	+	[https://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y H]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Fitzmaurice, A]]	+	[[Category: Chen Y-H]]
-	[[Category: He, L L]]	+	[[Category: Fitzmaurice A]]
-	[[Category: Li, M H]]	+	[[Category: He L-L]]
-	[[Category: Liang, T]]	+	[[Category: Li M-H]]
-	[[Category: Yamada, Y]]	+	[[Category: Liang T]]
-	[[Category: Yang, J]]	+	[[Category: Yamada Y]]
-	[[Category: Yang, S]]	+	[[Category: Yang J]]
-	[[Category: Zhang, H]]	+	[[Category: Yang S]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang H]]
-	~~[[Category: Aid doamin]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Calcium channel beta subunit]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Ionic channel]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Voltage-gated channel~~]]	+

OCA at 13:28, 13 October 2021

OCA — Wed, 13 Oct 2021 13:28:36 GMT

←Older revision		Revision as of 13:28, 13 October 2021
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	<StructureSection load='1vyu' size='340' side='right'caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1vyu' size='340' side='right'caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vyt\|1vyt]], [[1vyv\|1vyv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [~~http~~://pdbe.org/1vyu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vyu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [https://pdbe.org/1vyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [https://www.ebi.ac.uk/pdbsum/1vyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT]] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.	+	[[https://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT]] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:36, 8 January 2020

OCA — Wed, 08 Jan 2020 10:36:27 GMT

←Older revision		Revision as of 10:36, 8 January 2020
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	==Beta3 subunit of Voltage-gated Ca2+-channel==		==Beta3 subunit of Voltage-gated Ca2+-channel==
-	<StructureSection load='1vyu' size='340' side='right' caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1vyu' size='340' side='right'caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y H]]		[[Category: Chen, Y H]]
	[[Category: Fitzmaurice, A]]		[[Category: Fitzmaurice, A]]

OCA at 07:41, 4 April 2018

OCA — Wed, 04 Apr 2018 07:41:02 GMT

←Older revision		Revision as of 07:41, 4 April 2018
Line 1:		Line 1:
-	==~~BETA3 SUBUNIT OF VOLTAGE~~-~~GATED CA2~~+-~~CHANNEL~~==	+
		+	==Beta3 subunit of Voltage-gated Ca2+-channel==
	<StructureSection load='1vyu' size='340' side='right' caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1vyu' size='340' side='right' caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://pdbe.org/1vyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://pdbe.org/1vyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:37, 8 February 2016

OCA — Mon, 08 Feb 2016 13:37:00 GMT

←Older revision		Revision as of 13:37, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vyu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:05, 10 September 2015

OCA — Thu, 10 Sep 2015 12:05:19 GMT

←Older revision		Revision as of 12:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1vyu' size='340' side='right' caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1vyu' size='340' side='right' caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://pdbe.org/1vyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT]] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vyu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Chen, Y H]]		[[Category: Chen, Y H]]
	[[Category: Fitzmaurice, A]]		[[Category: Fitzmaurice, A]]

OCA at 12:59, 6 January 2015

OCA — Tue, 06 Jan 2015 12:59:30 GMT

←Older revision		Revision as of 12:59, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Chen, Y H.]]	+	[[Category: Chen, Y H]]
-	[[Category: Fitzmaurice, A.]]	+	[[Category: Fitzmaurice, A]]
-	[[Category: He, L L.]]	+	[[Category: He, L L]]
-	[[Category: Li, M H.]]	+	[[Category: Li, M H]]
-	[[Category: Liang, T.]]	+	[[Category: Liang, T]]
-	[[Category: Yamada, Y.]]	+	[[Category: Yamada, Y]]
-	[[Category: Yang, J.]]	+	[[Category: Yang, J]]
-	[[Category: Yang, S.]]	+	[[Category: Yang, S]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Aid doamin]]		[[Category: Aid doamin]]
	[[Category: Calcium channel beta subunit]]		[[Category: Calcium channel beta subunit]]

OCA at 21:15, 28 September 2014

OCA — Sun, 28 Sep 2014 21:15:43 GMT

←Older revision		Revision as of 21:15, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1vyu.~~png~~\|~~left~~\|200px]]	+	==BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL==
		+	<StructureSection load='1vyu' size='340' side='right' caption='[[1vyu]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyt\|1vyt]], [[1vyv\|1vyv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyu RCSB], [http://www.ebi.ac.uk/pdbsum/1vyu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-voltage-activated Ca2+ channels are essential for diverse biological processes. They are composed of four or five subunits, including alpha1, alpha2-delta, beta and gamma (ref. 1). Their expression and function are critically dependent on the beta-subunit, which transports alpha1 to the surface membrane and regulates diverse channel properties. It is believed that the beta-subunit interacts with alpha1 primarily through the beta-interaction domain (BID), which binds directly to the alpha-interaction domain (AID) of alpha1; however, the molecular mechanism of the alpha1-beta interaction is largely unclear. Here we report the crystal structures of the conserved core region of beta3, alone and in complex with AID, and of beta4 alone. The structures show that the beta-subunit core contains two interacting domains: a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain. The AID binds to a hydrophobic groove in the GK domain through extensive interactions, conferring extremely high affinity between alpha1 and beta-subunits. The BID is essential both for the structural integrity of and for bridging the SH3 and GK domains, but it does not participate directly in binding alpha1. The presence of multiple protein-interacting modules in the beta-subunit opens a new dimension to its function as a multi-functional protein.

-	~~{{STRUCTURE_1vyu\| PDB=1vyu \| SCENE= }}~~	+	Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.,Chen YH, Li MH, Zhang Y, He LL, Yamada Y, Fitzmaurice A, Shen Y, Zhang H, Tong L, Yang J Nature. 2004 Jun 10;429(6992):675-80. Epub 2004 May 30. PMID:15170217<ref>PMID:15170217</ref>

-	~~===BETA3 SUBUNIT OF VOLTAGE-GATED CA2+-CHANNEL===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15170217}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1vyu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA].~~	+

	==See Also==		==See Also==
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015170217<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chen, Y H.]]		[[Category: Chen, Y H.]]

OCA at 10:19, 20 October 2012

OCA — Sat, 20 Oct 2012 10:19:47 GMT

←Older revision		Revision as of 10:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1vyu]] is a 2 chain structure ~~of [[Ion channels]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA].	+	[[1vyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA].

	==See Also==		==See Also==

OCA at 19:00, 6 August 2012

OCA — Mon, 06 Aug 2012 19:00:07 GMT

←Older revision		Revision as of 19:00, 6 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1vyu]] is a 2 chain structure of ~~[[]] and~~ [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA].	+	[[1vyu]] is a 2 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYU OCA].

	==See Also==		==See Also==
-	*[[\|]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]