1vyx - Revision history

OCA at 13:27, 9 May 2024

OCA — Thu, 09 May 2024 13:27:49 GMT

←Older revision		Revision as of 13:27, 9 May 2024
Line 1:		Line 1:

	==Solution structure of the KSHV K3 N-terminal domain==		==Solution structure of the KSHV K3 N-terminal domain==
-	<StructureSection load='1vyx' size='340' side='right'caption='[[1vyx~~]], [[NMR_Ensembles_of_Models \| 28 NMR models~~]]' scene=''>	+	<StructureSection load='1vyx' size='340' side='right'caption='[[1vyx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hhv-8 Hhv-~~8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1chc\|1chc]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [https://pdbe.org/1vyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [https://www.ebi.ac.uk/pdbsum/1vyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [https://pdbe.org/1vyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [https://www.ebi.ac.uk/pdbsum/1vyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MIR1_HHV8P MIR1_HHV8P]] E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.<ref>PMID:10799607</ref> <ref>PMID:10859362</ref> <ref>PMID:11756476</ref> <ref>PMID:15864354</ref> <ref>PMID:15994556</ref>	+	[https://www.uniprot.org/uniprot/MIR1_HHV8P MIR1_HHV8P] E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.<ref>PMID:10799607</ref> <ref>PMID:10859362</ref> <ref>PMID:11756476</ref> <ref>PMID:15864354</ref> <ref>PMID:15994556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hhv-~~8]]	+	[[Category: Human gammaherpesvirus 8]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allen~~, M D~~]]	+	[[Category: Allen MD]]
-	[[Category: Brown~~, S E~~]]	+	[[Category: Brown SE]]
-	[[Category: Bycroft, M]]	+	[[Category: Bycroft M]]
-	[[Category: Dodd~~, R B~~]]	+	[[Category: Dodd RB]]
-	[[Category: Duncan~~, L M~~]]	+	[[Category: Duncan LM]]
-	[[Category: Read~~, R J~~]]	+	[[Category: Read RJ]]
-	[[Category: Sanderson~~, C M~~]]	+	[[Category: Sanderson CM]]
-	[[Category: Lehner~~, P J]]~~	+	[[Category: Lehner PJ]]
-	~~[[Category: Cross-brace motif]]~~	+
-	~~[[Category: Ring domain]]~~	+
-	~~[[Category: Zinc-binding protein~~]]	+

OCA at 08:16, 10 November 2021

OCA — Wed, 10 Nov 2021 08:16:17 GMT

←Older revision		Revision as of 08:16, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1vyx' size='340' side='right'caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>		<StructureSection load='1vyx' size='340' side='right'caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1VYX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1chc\|1chc]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [~~http~~://pdbe.org/1vyx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1vyx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [https://pdbe.org/1vyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [https://www.ebi.ac.uk/pdbsum/1vyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MIR1_HHV8P MIR1_HHV8P]] E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.<ref>PMID:10799607</ref> <ref>PMID:10859362</ref> <ref>PMID:11756476</ref> <ref>PMID:15864354</ref> <ref>PMID:15994556</ref>	+	[[https://www.uniprot.org/uniprot/MIR1_HHV8P MIR1_HHV8P]] E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.<ref>PMID:10799607</ref> <ref>PMID:10859362</ref> <ref>PMID:11756476</ref> <ref>PMID:15864354</ref> <ref>PMID:15994556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:23, 5 February 2020

OCA — Wed, 05 Feb 2020 09:23:24 GMT

←Older revision		Revision as of 09:23, 5 February 2020
Line 1:		Line 1:

	==Solution structure of the KSHV K3 N-terminal domain==		==Solution structure of the KSHV K3 N-terminal domain==
-	<StructureSection load='1vyx' size='340' side='right' caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>	+	<StructureSection load='1vyx' size='340' side='right'caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Hhv-8]]		[[Category: Hhv-8]]
		+	[[Category: Large Structures]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Brown, S E]]		[[Category: Brown, S E]]

OCA at 18:41, 24 January 2018

OCA — Wed, 24 Jan 2018 18:41:00 GMT

←Older revision		Revision as of 18:41, 24 January 2018
Line 1:		Line 1:
-	==~~SOLUTION STRUCTURE OF THE~~ KSHV K3 N-~~TERMINAL DOMAIN~~==	+
		+	==Solution structure of the KSHV K3 N-terminal domain==
	<StructureSection load='1vyx' size='340' side='right' caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>		<StructureSection load='1vyx' size='340' side='right' caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://pdbe.org/1vyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://pdbe.org/1vyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Dodd, R B]]		[[Category: Dodd, R B]]
	[[Category: Duncan, L M]]		[[Category: Duncan, L M]]
-	[[Category: Lehner, P J]]
	[[Category: Read, R J]]		[[Category: Read, R J]]
	[[Category: Sanderson, C M]]		[[Category: Sanderson, C M]]
		+	[[Category: Lehner, P J]]
	[[Category: Cross-brace motif]]		[[Category: Cross-brace motif]]
	[[Category: Ring domain]]		[[Category: Ring domain]]
	[[Category: Zinc-binding protein]]		[[Category: Zinc-binding protein]]

OCA at 20:02, 9 February 2016

OCA — Tue, 09 Feb 2016 20:02:49 GMT

←Older revision		Revision as of 20:02, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vyx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:34, 11 September 2015

OCA — Fri, 11 Sep 2015 01:34:15 GMT

←Older revision		Revision as of 01:34, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1vyx' size='340' side='right' caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>		<StructureSection load='1vyx' size='340' side='right' caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_herpesvirus_8 Human herpesvirus~~ 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://pdbe.org/1vyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIR1_HHV8P MIR1_HHV8P]] E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.<ref>PMID:10799607</ref> <ref>PMID:10859362</ref> <ref>PMID:11756476</ref> <ref>PMID:15864354</ref> <ref>PMID:15994556</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1vyx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human herpesvirus~~ 8]]	+	[[Category: Hhv-8]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Brown, S E]]		[[Category: Brown, S E]]

OCA at 12:20, 6 January 2015

OCA — Tue, 06 Jan 2015 12:20:42 GMT

←Older revision		Revision as of 12:20, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human herpesvirus 8]]		[[Category: Human herpesvirus 8]]
-	[[Category: Allen, M D.]]	+	[[Category: Allen, M D]]
-	[[Category: Brown, S E.]]	+	[[Category: Brown, S E]]
-	[[Category: Bycroft, M.]]	+	[[Category: Bycroft, M]]
-	[[Category: Dodd, R B.]]	+	[[Category: Dodd, R B]]
-	[[Category: Duncan, L M.]]	+	[[Category: Duncan, L M]]
-	[[Category: Lehner, P J.]]	+	[[Category: Lehner, P J]]
-	[[Category: Read, R J.]]	+	[[Category: Read, R J]]
-	[[Category: Sanderson, C M.]]	+	[[Category: Sanderson, C M]]
	[[Category: Cross-brace motif]]		[[Category: Cross-brace motif]]
	[[Category: Ring domain]]		[[Category: Ring domain]]
	[[Category: Zinc-binding protein]]		[[Category: Zinc-binding protein]]

OCA at 20:19, 29 September 2014

OCA — Mon, 29 Sep 2014 20:19:56 GMT

←Older revision		Revision as of 20:19, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1vyx.~~png~~\|~~left~~\|200px]]	+	==SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN==
		+	<StructureSection load='1vyx' size='340' side='right' caption='[[1vyx]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1chc\|1chc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vyx RCSB], [http://www.ebi.ac.uk/pdbsum/1vyx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RING domains are found in a large number of eukaryotic proteins. Most function as E3 ubiquitin-protein ligases, catalyzing the terminal step in the ubiquitination process. Structurally, these domains have been characterized as binding two zinc ions in a stable cross-brace motif. The tumorigenic human gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus encodes a ubiquitin-protein ligase termed K3, which functions as an immune evasion molecule by ubiquitinating major histocompatibility complex class I. K3 possesses at its N terminus a domain related to cellular RING domains but with an altered zinc ligand arrangement. This domain was initially characterized as a plant homeodomain, a structure not previously known to function as an E3. Here, it is conclusively demonstrated that the K3 N-terminal domain is a variant member of the RING domain family and not a plant homeodomain. The domain is found to interact with the cellular ubiquitin-conjugating enzymes UbcH5A to -C and UbcH13, which dock to the equivalent surface as on classical cellular RING domains. Interaction with UbcH13 suggests a possible role for K3 in catalyzing Lys(63)-linked ubiquitination.

-	~~{{STRUCTURE_1vyx\| PDB=1vyx \| SCENE= }}~~	+	Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.,Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ J Biol Chem. 2004 Dec 17;279(51):53840-7. Epub 2004 Sep 30. PMID:15465811<ref>PMID:15465811</ref>

-	~~===SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15465811}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1vyx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_herpesvirus_8 Human herpesvirus 8]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015465811<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Human herpesvirus 8]]		[[Category: Human herpesvirus 8]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D.]]

OCA: Protected "1vyx" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 10:58:46 GMT

Protected "1vyx" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:58, 5 January 2013

OCA at 10:58, 5 January 2013

OCA — Sat, 05 Jan 2013 10:58:44 GMT

←Older revision		Revision as of 10:58, 5 January 2013
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-	{{Seed}}
	[[Image:1vyx.png\|left\|200px]]		[[Image:1vyx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1vyx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1vyx\| PDB=1vyx \| SCENE= }}		{{STRUCTURE_1vyx\| PDB=1vyx \| SCENE= }}

	===SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN===		===SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15465811}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15465811 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15465811}}		{{ABSTRACT_PUBMED_15465811}}

	==About this Structure==		==About this Structure==
-	~~1VYX~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA].	+	[[1vyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15465811~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015465811</ref><references group="xtra"/>
	[[Category: Human herpesvirus 8]]		[[Category: Human herpesvirus 8]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D.]]
Line 36:		Line 24:
	[[Category: Ring domain]]		[[Category: Ring domain]]
	[[Category: Zinc-binding protein]]		[[Category: Zinc-binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:22:26 2009''