1w0g - Revision history

OCA at 13:10, 13 December 2023

OCA — Wed, 13 Dec 2023 13:10:46 GMT

←Older revision		Revision as of 13:10, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1w0g' size='340' side='right'caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='1w0g' size='340' side='right'caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~, ~~<scene name='pdbligand=MYT:METYRAPONE'>MYT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1w0e\|1w0e]]~~, ~~[[1w0f\|1w0f]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [https://pdbe.org/1w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [https://www.ebi.ac.uk/pdbsum/1w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [https://pdbe.org/1w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [https://www.ebi.ac.uk/pdbsum/1w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Angove~~, H C~~]]	+	[[Category: Angove HC]]
-	[[Category: Cosme, J]]	+	[[Category: Cosme J]]
-	[[Category: Day~~, P J~~]]	+	[[Category: Day PJ]]
-	[[Category: Jhoti, H]]	+	[[Category: Jhoti H]]
-	[[Category: Tickle~~, I J~~]]	+	[[Category: Tickle IJ]]
-	[[Category: Vinkovic~~, D M~~]]	+	[[Category: Vinkovic DM]]
-	[[Category: Vonrhein, C]]	+	[[Category: Vonrhein C]]
-	[[Category: Ward, A]]	+	[[Category: Ward A]]
-	[[Category: Williams~~, P A]]~~	+	[[Category: Williams PA]]
-	~~[[Category: Cytochrome p450]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Nifedipine oxidase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 13:29, 13 October 2021

OCA — Wed, 13 Oct 2021 13:29:25 GMT

←Older revision		Revision as of 13:29, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='1w0g' size='340' side='right'caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='1w0g' size='340' side='right'caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w0e\|1w0e]], [[1w0f\|1w0f]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [~~http~~://pdbe.org/1w0g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w0g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [https://pdbe.org/1w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [https://www.ebi.ac.uk/pdbsum/1w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:48, 8 January 2020

OCA — Wed, 08 Jan 2020 10:48:36 GMT

←Older revision		Revision as of 10:48, 8 January 2020
Line 1:		Line 1:

	==Crystal structure of human cytochrome P450 3A4==		==Crystal structure of human cytochrome P450 3A4==
-	<StructureSection load='1w0g' size='340' side='right' caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='1w0g' size='340' side='right'caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]	+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Angove, H C]]		[[Category: Angove, H C]]
	[[Category: Cosme, J]]		[[Category: Cosme, J]]

OCA at 07:50, 4 April 2018

OCA — Wed, 04 Apr 2018 07:50:38 GMT

←Older revision		Revision as of 07:50, 4 April 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF HUMAN CYTOCHROME~~ P450 3A4==	+
		+	==Crystal structure of human cytochrome P450 3A4==
	<StructureSection load='1w0g' size='340' side='right' caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='1w0g' size='340' side='right' caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://pdbe.org/1w0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://pdbe.org/1w0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/1w0g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/1w0g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:37, 8 February 2016

OCA — Mon, 08 Feb 2016 17:37:52 GMT

←Older revision		Revision as of 17:37, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w0g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:53, 10 September 2015

OCA — Thu, 10 Sep 2015 13:53:34 GMT

←Older revision		Revision as of 13:53, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1w0g' size='340' side='right' caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='1w0g' size='340' side='right' caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://pdbe.org/1w0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w0g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Angove, H C]]		[[Category: Angove, H C]]
	[[Category: Cosme, J]]		[[Category: Cosme, J]]

OCA at 13:12, 6 January 2015

OCA — Tue, 06 Jan 2015 13:12:02 GMT

←Older revision		Revision as of 13:12, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Angove, H C.]]	+	[[Category: Angove, H C]]
-	[[Category: Cosme, J.]]	+	[[Category: Cosme, J]]
-	[[Category: Day, P J.]]	+	[[Category: Day, P J]]
-	[[Category: Jhoti, H.]]	+	[[Category: Jhoti, H]]
-	[[Category: Tickle, I J.]]	+	[[Category: Tickle, I J]]
-	[[Category: Vinkovic, D M.]]	+	[[Category: Vinkovic, D M]]
-	[[Category: Vonrhein, C.]]	+	[[Category: Vonrhein, C]]
-	[[Category: Ward, A.]]	+	[[Category: Ward, A]]
-	[[Category: Williams, P A.]]	+	[[Category: Williams, P A]]
	[[Category: Cytochrome p450]]		[[Category: Cytochrome p450]]
	[[Category: Electron transport]]		[[Category: Electron transport]]

OCA at 22:37, 28 September 2014

OCA — Sun, 28 Sep 2014 22:37:06 GMT

←Older revision		Revision as of 22:37, 28 September 2014
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-	[[~~Image:~~1w0g.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4==
		+	<StructureSection load='1w0g' size='340' side='right' caption='[[1w0g]], [[Resolution\|resolution]] 2.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W0G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYT:METYRAPONE'>MYT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w0e\|1w0e]], [[1w0f\|1w0f]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w0g RCSB], [http://www.ebi.ac.uk/pdbsum/1w0g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/1w0g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds and xenobiotics, such as pollutants, environmental compounds, and drug molecules. The microsomal, membrane-associated, P450 isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, and CYP1A2 are responsible for the oxidative metabolism of more than 90% of marketed drugs. Cytochrome P450 3A4 (CYP3A4) metabolizes more drug molecules than all other isoforms combined. Here we report three crystal structures of CYP3A4: unliganded, bound to the inhibitor metyrapone, and bound to the substrate progesterone. The structures revealed a surprisingly small active site, with little conformational change associated with the binding of either compound. An unexpected peripheral binding site is identified, located above a phenylalanine cluster, which may be involved in the initial recognition of substrates or allosteric effectors.

-	~~{{STRUCTURE_1w0g\| PDB=1w0g \| SCENE= }}~~	+	Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.,Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15. PMID:15256616<ref>PMID:15256616</ref>

-	~~===CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15256616}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1w0g]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA].~~	+

	==See Also==		==See Also==
	*[[Cytochrome P450\|Cytochrome P450]]		*[[Cytochrome P450\|Cytochrome P450]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015256616<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Angove, H C.]]		[[Category: Angove, H C.]]

OCA at 10:55, 20 October 2012

OCA — Sat, 20 Oct 2012 10:55:40 GMT

←Older revision		Revision as of 10:55, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1w0g]] is a 1 chain structure ~~of [[Cytochrome P450]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA].	+	[[1w0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0G OCA].

	==See Also==		==See Also==

OCA at 03:41, 26 July 2012

OCA — Thu, 26 Jul 2012 03:41:51 GMT

←Older revision		Revision as of 03:41, 26 July 2012
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	[[Image:1w0g.png\|left\|200px]]		[[Image:1w0g.png\|left\|200px]]

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	===CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4===		===CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4===

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	==See Also==		==See Also==
-	*[[Cytochrome P450]]	+	*[[Cytochrome P450\|Cytochrome P450]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15256616~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015256616</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Angove, H C.]]		[[Category: Angove, H C.]]