1w13 - Revision history

OCA at 13:28, 9 May 2024

OCA — Thu, 09 May 2024 13:28:52 GMT

←Older revision		Revision as of 13:28, 9 May 2024
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	<StructureSection load='1w13' size='340' side='right'caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1w13' size='340' side='right'caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W13 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SM1:N~~-~~(BENZYLSULFONYL)-D-SERYL-N-(4-{~~[~~AMINO(IMINO)METHYL~~]~~AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[1c5w\|1c5w~~]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</div></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [https://pdbe.org/1w13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [https://www.ebi.ac.uk/pdbsum/1w13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w13 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [https://pdbe.org/1w13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [https://www.ebi.ac.uk/pdbsum/1w13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w13 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>	+	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.	+	[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: U-plasminogen activator]]~~	+	[[Category: Jacob U]]
-	[[Category: Jacob, U]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Plasminogen activator]]~~	+
-	~~[[Category: Urokinase~~]]	+

OCA at 07:08, 24 February 2021

OCA — Wed, 24 Feb 2021 07:08:34 GMT

←Older revision		Revision as of 07:08, 24 February 2021
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	<StructureSection load='1w13' size='340' side='right'caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1w13' size='340' side='right'caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W13 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [~~http~~://pdbe.org/1w13 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w13 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w13 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [https://pdbe.org/1w13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [https://www.ebi.ac.uk/pdbsum/1w13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w13 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[~~http~~://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>	+	[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.	+	[[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Urokinase\|Urokinase]]	+	*[[Urokinase 3D Structures\|Urokinase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:07, 23 May 2019

OCA — Thu, 23 May 2019 07:07:50 GMT

←Older revision		Revision as of 07:07, 23 May 2019
Line 1:		Line 1:

	==UROKINASE TYPE PLASMINOGEN ACTIVATOR==		==UROKINASE TYPE PLASMINOGEN ACTIVATOR==
-	<StructureSection load='1w13' size='340' side='right' caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1w13' size='340' side='right'caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Jacob, U]]		[[Category: Jacob, U]]

OCA at 07:15, 4 April 2018

OCA — Wed, 04 Apr 2018 07:15:28 GMT

←Older revision		Revision as of 07:15, 4 April 2018
Line 1:		Line 1:
		+
	==UROKINASE TYPE PLASMINOGEN ACTIVATOR==		==UROKINASE TYPE PLASMINOGEN ACTIVATOR==
	<StructureSection load='1w13' size='340' side='right' caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1w13' size='340' side='right' caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://pdbe.org/1w13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://pdbe.org/1w13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w13 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w1/1w13_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w1/1w13_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:09, 8 February 2016

OCA — Mon, 08 Feb 2016 16:09:06 GMT

←Older revision		Revision as of 16:09, 8 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w13 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:15, 10 September 2015

OCA — Thu, 10 Sep 2015 13:15:20 GMT

←Older revision		Revision as of 13:15, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1w13' size='340' side='right' caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1w13' size='340' side='right' caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://pdbe.org/1w13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w13" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Jacob, U]]		[[Category: Jacob, U]]

OCA at 12:22, 6 January 2015

OCA — Tue, 06 Jan 2015 12:22:15 GMT

←Older revision		Revision as of 12:22, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
Line 39:		Line 39:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
-	[[Category: Jacob, U.]]	+	[[Category: Jacob, U]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Plasminogen activator]]		[[Category: Plasminogen activator]]
	[[Category: Urokinase]]		[[Category: Urokinase]]

OCA at 20:20, 29 September 2014

OCA — Mon, 29 Sep 2014 20:20:29 GMT

←Older revision		Revision as of 20:20, 29 September 2014
Line 1:		Line 1:
-	{~~{STRUCTURE_1w13~~\| ~~PDB~~=1w13 \| ~~SCENE~~= }}	+	==UROKINASE TYPE PLASMINOGEN ACTIVATOR==
-	===~~UROKINASE TYPE PLASMINOGEN ACTIVATOR~~===	+	<StructureSection load='1w13' size='340' side='right' caption='[[1w13]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12684001}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W13 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM1:N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE'>SM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5w\|1c5w]], [[1c5x\|1c5x]], [[1c5y\|1c5y]], [[1c5z\|1c5z]], [[1ejn\|1ejn]], [[1f5k\|1f5k]], [[1f5l\|1f5l]], [[1f92\|1f92]], [[1fv9\|1fv9]], [[1gi7\|1gi7]], [[1gi8\|1gi8]], [[1gi9\|1gi9]], [[1gj7\|1gj7]], [[1gj8\|1gj8]], [[1gj9\|1gj9]], [[1gja\|1gja]], [[1gjb\|1gjb]], [[1gjc\|1gjc]], [[1gjd\|1gjd]], [[1kdu\|1kdu]], [[1lmw\|1lmw]], [[1o3p\|1o3p]], [[1owd\|1owd]], [[1owe\|1owe]], [[1owh\|1owh]], [[1owi\|1owi]], [[1owj\|1owj]], [[1owk\|1owk]], [[1sqa\|1sqa]], [[1sqo\|1sqo]], [[1sqt\|1sqt]], [[1urk\|1urk]], [[1w0z\|1w0z]], [[1w10\|1w10]], [[1w11\|1w11]], [[1w12\|1w12]], [[1w14\|1w14]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w13 RCSB], [http://www.ebi.ac.uk/pdbsum/1w13 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w1/1w13_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Urokinase type plasminogen activator (uPA), a trypsin-like serine proteinase, plays an important role in normal tissue re-modelling, cell adhesion, and cell motility. In addition, studies utilizing normal animals and potent, selective uPA inhibitors or genetically modified mice that lack functional uPA genes have demonstrated that uPA can significantly enhance tumor initiation, growth, progression and metastasis, strongly suggesting that this enzyme may be a promising anti-cancer target. We have investigated the structure-activity relationship (SAR) of peptidomimetic inhibitors of uPA and solved high resolution X-ray structures of key, lead small molecule inhibitors (e.g. phenethylsulfonamidino(P4)-D-seryl(P3)-L-alanyl(P2)-L-argininal(P1) and derivatives thereof) in complex with the uPA proteinase domain. These potent inhibitors are highly selective for uPA. The non-natural D-seryl residue present at the P3 position in these inhibitors contributes substantially to both potency and selectivity because, due to its D-configuration, its side-chain binds in the S4 pocket to interact with the uPA unique residues Leu97b and His99. Additional potency and selectivity can be achieved by optimizing the inhibitor P4 residue to bind a pocket, known as S1sub or S1beta, that is adjacent to the primary specificity pocket of uPA.

-	~~==Disease==~~	+	Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors.,Zeslawska E, Jacob U, Schweinitz A, Coombs G, Bode W, Madison E J Mol Biol. 2003 Apr 18;328(1):109-18. PMID:12684001<ref>PMID:12684001</ref>
-	~~[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are~~ the ~~cause~~ of ~~Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis~~. ~~Although affected individuals do not exhibit systemic fibrinolysis~~, ~~they show delayed onset bleeding after challenge~~, ~~such as surgery~~. ~~The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha~~-~~granule proteins~~.<ref>PMID:~~20007542~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[1w13]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA].~~	+

	==See Also==		==See Also==
	*[[Urokinase\|Urokinase]]		*[[Urokinase\|Urokinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012684001</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]

OCA at 18:15, 24 March 2013

OCA — Sun, 24 Mar 2013 18:15:38 GMT

←Older revision		Revision as of 18:15, 24 March 2013
Line 1:		Line 1:
-	[[Image:1w13.png\|left\|200px]]
-
	{{STRUCTURE_1w13\| PDB=1w13 \| SCENE= }}		{{STRUCTURE_1w13\| PDB=1w13 \| SCENE= }}
-
	===UROKINASE TYPE PLASMINOGEN ACTIVATOR===		===UROKINASE TYPE PLASMINOGEN ACTIVATOR===
		+	{{ABSTRACT_PUBMED_12684001}}

-	~~{{ABSTRACT_PUBMED_12684001}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012684001</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012684001</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]

OCA at 10:42, 20 October 2012

OCA — Sat, 20 Oct 2012 10:42:35 GMT

←Older revision		Revision as of 10:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1w13]] is a 1 chain structure ~~of [[Urokinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA].	+	[[1w13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W13 OCA].

	==See Also==		==See Also==