1w20 - Revision history

OCA at 13:12, 13 December 2023

OCA — Wed, 13 Dec 2023 13:12:26 GMT

←Older revision		Revision as of 13:12, 13 December 2023
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	<StructureSection load='1w20' size='340' side='right'caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='1w20' size='340' side='right'caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9infa 9infa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1W20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W20 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.08Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [https://pdbe.org/1w20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [https://www.ebi.ac.uk/pdbsum/1w20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w20 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [~~http~~://pdbe.org/1w20 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w20 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w20 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.	+	[https://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Exo-alpha-sialidase~~]]	+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Crennell~~, S J~~]]	+	[[Category: Crennell SJ]]
-	[[Category: Garman~~, E F~~]]	+	[[Category: Garman EF]]
-	[[Category: Laver~~, W G~~]]	+	[[Category: Laver WG]]
-	[[Category: Rudino-Pinera, E]]	+	[[Category: Rudino-Pinera E]]
-	[[Category: Tunnah, P]]	+	[[Category: Tunnah P]]
-	[[Category: Webster~~, R G]]~~	+	[[Category: Webster RG]]
-	~~[[Category: Hb site]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Influenza type some]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Subtype n6~~]]	+

OCA at 07:42, 30 December 2020

OCA — Wed, 30 Dec 2020 07:42:23 GMT

←Older revision		Revision as of 07:42, 30 December 2020
Line 1:		Line 1:

	==Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K==		==Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K==
-	<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='1w20' size='340' side='right'caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1W20 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://pdbe.org/1w20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w20 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://pdbe.org/1w20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w20 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: Large Structures]]
	[[Category: Crennell, S J]]		[[Category: Crennell, S J]]
	[[Category: Garman, E F]]		[[Category: Garman, E F]]

OCA at 07:44, 6 March 2019

OCA — Wed, 06 Mar 2019 07:44:06 GMT

←Older revision		Revision as of 07:44, 6 March 2019
Line 1:		Line 1:

	==Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K==		==Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K==
-	<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>

OCA at 07:22, 4 April 2018

OCA — Wed, 04 Apr 2018 07:22:57 GMT

←Older revision		Revision as of 07:22, 4 April 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE~~ N6 ~~COMPLEXED WITH~~ 30 ~~MM SIALIC ACID~~ (NANA, ~~NEU5AC~~), ~~CRYSTAL SOAKED FOR~~ 3 ~~HOURS AT~~ 291 K==	+
		+	==Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K==
	<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://pdbe.org/1w20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://pdbe.org/1w20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w20 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w20_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w20_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:02, 9 February 2016

OCA — Tue, 09 Feb 2016 11:02:55 GMT

←Older revision		Revision as of 11:02, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w20 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 21:39, 10 September 2015

OCA — Thu, 10 Sep 2015 21:39:55 GMT

←Older revision		Revision as of 21:39, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://pdbe.org/1w20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: Influenza a virus]]
	[[Category: Crennell, S J]]		[[Category: Crennell, S J]]
	[[Category: Garman, E F]]		[[Category: Garman, E F]]

OCA at 13:33, 6 January 2015

OCA — Tue, 06 Jan 2015 13:33:21 GMT

←Older revision		Revision as of 13:33, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Crennell, S J.]]	+	[[Category: Crennell, S J]]
-	[[Category: Garman, E F.]]	+	[[Category: Garman, E F]]
-	[[Category: Laver, W G.]]	+	[[Category: Laver, W G]]
-	[[Category: Rudino-Pinera, E.]]	+	[[Category: Rudino-Pinera, E]]
-	[[Category: Tunnah, P.]]	+	[[Category: Tunnah, P]]
-	[[Category: Webster, R G.]]	+	[[Category: Webster, R G]]
	[[Category: Hb site]]		[[Category: Hb site]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 23:51, 28 September 2014

OCA — Sun, 28 Sep 2014 23:51:38 GMT

←Older revision		Revision as of 23:51, 28 September 2014
Line 1:		Line 1:
-	~~[[Image:1w20.png\|left\|200px]]~~	+	==STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM SIALIC ACID (NANA, NEU5AC), CRYSTAL SOAKED FOR 3 HOURS AT 291 K==
-		+	<StructureSection load='1w20' size='340' side='right' caption='[[1w20]], [[Resolution\|resolution]] 2.08Å' scene=''>
-	~~{{STRUCTURE_1w20\| PDB=1w20 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W20 FirstGlance]. <br>
-	===STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM SIALIC ACID (NANA, NEU5AC), CRYSTAL SOAKED FOR 3 HOURS AT 291 K===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a14\|1a14]], [[1a4g\|1a4g]], [[1a4q\|1a4q]], [[1b9s\|1b9s]], [[1b9t\|1b9t]], [[1b9v\|1b9v]], [[1bji\|1bji]], [[1e8t\|1e8t]], [[1e8u\|1e8u]], [[1e8v\|1e8v]], [[1euu\|1euu]], [[1f8b\|1f8b]], [[1f8c\|1f8c]], [[1f8d\|1f8d]], [[1f8e\|1f8e]], [[1inf\|1inf]], [[1ing\|1ing]], [[1inh\|1inh]], [[1inv\|1inv]], [[1inw\|1inw]], [[1inx\|1inx]], [[1iny\|1iny]], [[1ivb\|1ivb]], [[1ivc\|1ivc]], [[1ivd\|1ivd]], [[1ive\|1ive]], [[1ivf\|1ivf]], [[1ivg\|1ivg]], [[1kit\|1kit]], [[1l7f\|1l7f]], [[1l7g\|1l7g]], [[1l7h\|1l7h]], [[1mwe\|1mwe]], [[1nca\|1nca]], [[1ncb\|1ncb]], [[1ncc\|1ncc]], [[1ncd\|1ncd]], [[1nma\|1nma]], [[1nmb\|1nmb]], [[1nmc\|1nmc]], [[1nn2\|1nn2]], [[1nna\|1nna]], [[1nnb\|1nnb]], [[1nnc\|1nnc]], [[1nsb\|1nsb]], [[1nsc\|1nsc]], [[1nsd\|1nsd]], [[1usr\|1usr]], [[1usx\|1usx]], [[1v2i\|1v2i]], [[1v3b\|1v3b]], [[1v3c\|1v3c]], [[1v3d\|1v3d]], [[1v3e\|1v3e]], [[1vcj\|1vcj]], [[1w1x\|1w1x]], [[1w21\|1w21]], [[1v0z\|1v0z]], [[1w8n\|1w8n]], [[1w8o\|1w8o]], [[1xoe\|1xoe]], [[1xog\|1xog]], [[1z4v\|1z4v]], [[1z4w\|1z4w]], [[1z4x\|1z4x]], [[1z4y\|1z4y]], [[1z4z\|1z4z]], [[1z50\|1z50]], [[2bat\|2bat]], [[2qwa\|2qwa]], [[2qwb\|2qwb]], [[2qwc\|2qwc]], [[2qwd\|2qwd]], [[2qwe\|2qwe]], [[2qwf\|2qwf]], [[2qwg\|2qwg]], [[2qwh\|2qwh]], [[2qwi\|2qwi]], [[2qwj\|2qwj]], [[2qwk\|2qwk]], [[2sil\|2sil]], [[2sim\|2sim]], [[3nn9\|3nn9]], [[4nn9\|4nn9]], [[5nn9\|5nn9]], [[6nn9\|6nn9]], [[7nn9\|7nn9]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w20 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w20 RCSB], [http://www.ebi.ac.uk/pdbsum/1w20 PDBsum]</span></td></tr>
-	[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w20_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]

OCA at 13:40, 20 October 2012

OCA — Sat, 20 Oct 2012 13:40:03 GMT

←Older revision		Revision as of 13:40, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[1w20]] is a 4 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA].	+	[[1w20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W20 OCA].

	==See Also==		==See Also==

OCA: Protected "1w20" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 12:42:26 GMT

Protected "1w20" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 26 July 2012