1w27 - Revision history

OCA at 08:07, 15 November 2023

OCA — Wed, 15 Nov 2023 08:07:55 GMT

←Older revision		Revision as of 08:07, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='1w27' size='340' side='right'caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1w27' size='340' side='right'caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Petcr Petcr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W27 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DTT:2~~,~~3-DIHYDROXY-~~1~~,4-DITHIOBUTANE'>DTT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lyase Lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [https://pdbe.org/1w27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [https://www.ebi.ac.uk/pdbsum/1w27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w27 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [https://pdbe.org/1w27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [https://www.ebi.ac.uk/pdbsum/1w27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PAL1_PETCR PAL1_PETCR]] This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.	+	[https://www.uniprot.org/uniprot/PAL1_PETCR PAL1_PETCR] This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lyase]]~~	+	[[Category: Petroselinum crispum]]
-	~~[[Category: Petcr~~]]	+	[[Category: Ritter H]]
-	[[Category: Ritter, H]]	+	[[Category: Schulz GE]]
-	[[Category: Schulz~~, G E]]~~	+
-	~~[[Category: Mio]]~~	+
-	~~[[Category: Phenylpropanoid metabolism~~]]	+

OCA at 13:30, 13 October 2021

OCA — Wed, 13 Oct 2021 13:30:39 GMT

←Older revision		Revision as of 13:30, 13 October 2021
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	<StructureSection load='1w27' size='340' side='right'caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1w27' size='340' side='right'caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Petcr Petcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Petcr Petcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lyase Lyase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lyase Lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [~~http~~://pdbe.org/1w27 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w27 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w27 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [https://pdbe.org/1w27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [https://www.ebi.ac.uk/pdbsum/1w27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PAL1_PETCR PAL1_PETCR]] This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.	+	[[https://www.uniprot.org/uniprot/PAL1_PETCR PAL1_PETCR]] This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:11, 8 January 2020

OCA — Wed, 08 Jan 2020 10:11:00 GMT

←Older revision		Revision as of 10:11, 8 January 2020
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	==Phenylalanine ammonia-lyase (PAL) from Petroselinum crispum==		==Phenylalanine ammonia-lyase (PAL) from Petroselinum crispum==
-	<StructureSection load='1w27' size='340' side='right' caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1w27' size='340' side='right'caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petcr Petcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petcr Petcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Aminomutase\|Aminomutase]]	+	*[[Aminomutase 3D structures\|Aminomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Petcr]]		[[Category: Petcr]]

OCA at 07:17, 4 April 2018

OCA — Wed, 04 Apr 2018 07:17:18 GMT

←Older revision		Revision as of 07:17, 4 April 2018
Line 1:		Line 1:
-	==~~PHENYLALANINE AMMONIA~~-~~LYASE~~ (PAL) ~~FROM PETROSELINUM CRISPUM~~==	+
		+	==Phenylalanine ammonia-lyase (PAL) from Petroselinum crispum==
	<StructureSection load='1w27' size='340' side='right' caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1w27' size='340' side='right' caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://pdbe.org/1w27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://pdbe.org/1w27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w27_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w27_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w27 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1w27" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1w27" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminomutase\|Aminomutase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:06, 12 September 2015

OCA — Sat, 12 Sep 2015 02:06:29 GMT

←Older revision		Revision as of 02:06, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1w27' size='340' side='right' caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1w27' size='340' side='right' caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Petroselinum_crispum Petroselinum crispum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petcr Petcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://pdbe.org/1w27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w27" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Lyase]]		[[Category: Lyase]]
-	[[Category: ~~Petroselinum crispum~~]]	+	[[Category: Petcr]]
	[[Category: Ritter, H]]		[[Category: Ritter, H]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]
	[[Category: Mio]]		[[Category: Mio]]
	[[Category: Phenylpropanoid metabolism]]		[[Category: Phenylpropanoid metabolism]]

OCA at 22:27, 25 December 2014

OCA — Thu, 25 Dec 2014 22:27:30 GMT

←Older revision		Revision as of 22:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAL1_PETCR PAL1_PETCR]] This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Petroselinum crispum]]		[[Category: Petroselinum crispum]]
-	[[Category: Ritter, H.]]	+	[[Category: Ritter, H]]
-	[[Category: Schulz, G E~~.]]~~	+	[[Category: Schulz, G E]]
-	~~[[Category: Lyase~~]]	+
	[[Category: Mio]]		[[Category: Mio]]
	[[Category: Phenylpropanoid metabolism]]		[[Category: Phenylpropanoid metabolism]]

OCA at 21:46, 29 September 2014

OCA — Mon, 29 Sep 2014 21:46:52 GMT

←Older revision		Revision as of 21:46, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1w27.~~png~~\|~~left~~\|200px]]	+	==PHENYLALANINE AMMONIA-LYASE (PAL) FROM PETROSELINUM CRISPUM==
		+	<StructureSection load='1w27' size='340' side='right' caption='[[1w27]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W27 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.23, 4.3.1.24 and 4.3.1.25 4.3.1.23, 4.3.1.24 and 4.3.1.25] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w27 RCSB], [http://www.ebi.ac.uk/pdbsum/1w27 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w27_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Because of its key role in secondary phenylpropanoid metabolism, Phe ammonia-lyase is one of the most extensively studied plant enzymes. To provide a basis for detailed structure-function studies, the enzyme from parsley (Petroselinum crispum) was crystallized, and the structure was elucidated at 1.7-A resolution. It contains the unusual electrophilic 4-methylidene-imidazole-5-one group, which is derived from a tripeptide segment in two autocatalytic dehydration reactions. The enzyme resembles His ammonia-lyase from the general His degradation pathway but contains 207 additional residues, mainly in an N-terminal extension rigidifying a domain interface and in an inserted alpha-helical domain restricting the access to the active center. Presumably, Phe ammonia-lyase developed from His ammonia-lyase when fungi and plants diverged from the other kingdoms. A pathway of the catalyzed reaction is proposed in agreement with established biochemical data. The inactivation of the enzyme by a nucleophile is described in detail.

-	~~{{STRUCTURE_1w27\| PDB=1w27 \| SCENE= }}~~	+	Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase.,Ritter H, Schulz GE Plant Cell. 2004 Dec;16(12):3426-36. Epub 2004 Nov 17. PMID:15548745<ref>PMID:15548745</ref>

-	~~===PHENYLALANINE AMMONIA-LYASE (PAL) FROM PETROSELINUM CRISPUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15548745}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1w27]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Petroselinum_crispum Petroselinum crispum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015548745<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Petroselinum crispum]]		[[Category: Petroselinum crispum]]

OCA: Protected "1w27" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:15:21 GMT

Protected "1w27" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:15, 5 January 2013

OCA at 13:15, 5 January 2013

OCA — Sat, 05 Jan 2013 13:15:18 GMT

←Older revision		Revision as of 13:15, 5 January 2013
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-	{{Seed}}
	[[Image:1w27.png\|left\|200px]]		[[Image:1w27.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w27", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w27\| PDB=1w27 \| SCENE= }}		{{STRUCTURE_1w27\| PDB=1w27 \| SCENE= }}

	===PHENYLALANINE AMMONIA-LYASE (PAL) FROM PETROSELINUM CRISPUM===		===PHENYLALANINE AMMONIA-LYASE (PAL) FROM PETROSELINUM CRISPUM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15548745}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15548745 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15548745}}		{{ABSTRACT_PUBMED_15548745}}

	==About this Structure==		==About this Structure==
-	~~1W27~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA].	+	[[1w27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15548745~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015548745</ref><references group="xtra"/>
		+	[[Category: Lyase]]
	[[Category: Petroselinum crispum]]		[[Category: Petroselinum crispum]]
-	[[Category: Phenylalanine ammonia-lyase]]
	[[Category: Ritter, H.]]		[[Category: Ritter, H.]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]
Line 31:		Line 19:
	[[Category: Mio]]		[[Category: Mio]]
	[[Category: Phenylpropanoid metabolism]]		[[Category: Phenylpropanoid metabolism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:43:36 2009''

OCA at 07:43, 18 February 2009

OCA — Wed, 18 Feb 2009 07:43:37 GMT

←Older revision		Revision as of 07:43, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1W27 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA].	+	1W27 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Petroselinum_crispum Petroselinum crispum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W27 OCA].

	==Reference==		==Reference==
-	~~Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase., Ritter H, Schulz GE, Plant Cell. 2004 Dec;16(12):3426-36. Epub 2004 Nov 17.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15548745 15548745]~~	+	<ref group="xtra">PMID:15548745</ref><references group="xtra"/>
	[[Category: Petroselinum crispum]]		[[Category: Petroselinum crispum]]
	[[Category: Phenylalanine ammonia-lyase]]		[[Category: Phenylalanine ammonia-lyase]]
-	[[Category: Single protein]]
	[[Category: Ritter, H.]]		[[Category: Ritter, H.]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E.]]
Line 33:		Line 32:
	[[Category: Phenylpropanoid metabolism]]		[[Category: Phenylpropanoid metabolism]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16~~:02:~~15 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:43:36 2009''