1w2r - Revision history

OCA at 09:09, 9 May 2024

OCA — Thu, 09 May 2024 09:09:54 GMT

←Older revision		Revision as of 09:09, 9 May 2024
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	<StructureSection load='1w2r' size='340' side='right'caption='[[1w2r]]' scene=''>		<StructureSection load='1w2r' size='340' side='right'caption='[[1w2r]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [https://pdbe.org/1w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [https://www.ebi.ac.uk/pdbsum/1w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [https://pdbe.org/1w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [https://www.ebi.ac.uk/pdbsum/1w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[https://omim.org/entry/610927 610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref> Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[https://omim.org/entry/614699 614699]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN] Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.<ref>PMID:7753047</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilbert~~, H E~~]]	+	[[Category: Gilbert HE]]
-	[[Category: Hannan~~, J P~~]]	+	[[Category: Hannan JP]]
-	[[Category: Holers~~, V M~~]]	+	[[Category: Holers VM]]
-	[[Category: Perkins~~, S J]]~~	+	[[Category: Perkins SJ]]
-	~~[[Category: Analytical ultracentrifugation]]~~	+
-	~~[[Category: Constrained modelling]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Thrombospondin type i repeat~~]]	+

OCA at 13:31, 13 October 2021

OCA — Wed, 13 Oct 2021 13:31:07 GMT

←Older revision		Revision as of 13:31, 13 October 2021
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	<StructureSection load='1w2r' size='340' side='right'caption='[[1w2r]]' scene=''>		<StructureSection load='1w2r' size='340' side='right'caption='[[1w2r]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W2R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [~~http~~://pdbe.org/1w2r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w2r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [https://pdbe.org/1w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [https://www.ebi.ac.uk/pdbsum/1w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2r ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:14, 8 January 2020

OCA — Wed, 08 Jan 2020 10:14:23 GMT

←Older revision		Revision as of 10:14, 8 January 2020
Line 1:		Line 1:

	==Solution structure of CR2 SCR 1-2 by X-ray scattering==		==Solution structure of CR2 SCR 1-2 by X-ray scattering==
-	<StructureSection load='1w2r' size='340' side='right' caption='[[1w2r]]' scene=''>	+	<StructureSection load='1w2r' size='340' side='right'caption='[[1w2r]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gilbert, H E]]		[[Category: Gilbert, H E]]
	[[Category: Hannan, J P]]		[[Category: Hannan, J P]]

OCA at 07:20, 4 April 2018

OCA — Wed, 04 Apr 2018 07:20:27 GMT

←Older revision		Revision as of 07:20, 4 April 2018
Line 1:		Line 1:
		+
	==Solution structure of CR2 SCR 1-2 by X-ray scattering==		==Solution structure of CR2 SCR 1-2 by X-ray scattering==
	<StructureSection load='1w2r' size='340' side='right' caption='[[1w2r]]' scene=''>		<StructureSection load='1w2r' size='340' side='right' caption='[[1w2r]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://pdbe.org/1w2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://pdbe.org/1w2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2r ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w2r_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w2r_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w2r ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:21, 11 September 2015

OCA — Fri, 11 Sep 2015 08:21:48 GMT

←Older revision		Revision as of 08:21, 11 September 2015
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	<StructureSection load='1w2r' size='340' side='right' caption='[[1w2r]]' scene=''>		<StructureSection load='1w2r' size='340' side='right' caption='[[1w2r]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://pdbe.org/1w2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w2r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gilbert, H E]]		[[Category: Gilbert, H E]]
	[[Category: Hannan, J P]]		[[Category: Hannan, J P]]

OCA at 13:30, 6 January 2015

OCA — Tue, 06 Jan 2015 13:30:00 GMT

←Older revision		Revision as of 13:30, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gilbert, H E.]]	+	[[Category: Gilbert, H E]]
-	[[Category: Hannan, J P.]]	+	[[Category: Hannan, J P]]
-	[[Category: Holers, V M.]]	+	[[Category: Holers, V M]]
-	[[Category: Perkins, S J.]]	+	[[Category: Perkins, S J]]
	[[Category: Analytical ultracentrifugation]]		[[Category: Analytical ultracentrifugation]]
	[[Category: Constrained modelling]]		[[Category: Constrained modelling]]

OCA at 20:52, 29 September 2014

OCA — Mon, 29 Sep 2014 20:52:07 GMT

←Older revision		Revision as of 20:52, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1w2r~~\| ~~PDB~~=1w2r \| ~~SCENE~~= }}	+	==Solution structure of CR2 SCR 1-2 by X-ray scattering==
-	===~~SOLUTION STRUCTURE OF~~ CR2 SCR 1-2 BY X-~~RAY SCATTERING===~~	+	<StructureSection load='1w2r' size='340' side='right' caption='[[1w2r]]' scene=''>
-	~~{{ABSTRACT_PUBMED_15713468}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W2R FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ghq\|1ghq]], [[1ly2\|1ly2]], [[1w2s\|1w2s]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w2r RCSB], [http://www.ebi.ac.uk/pdbsum/1w2r PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/1w2r_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complement receptor type 2 (CR2, CD21) forms a tight complex with C3d, a fragment of C3, the major complement component. Previous crystal structures of the C3d-CR2 SCR 1-2 complex and free CR2 SCR 1-2 showed that the two SCR domains of CR2 form contact with each other in a closed V-shaped structure. SCR 1 and SCR 2 are connected by an unusually long eight-residue linker peptide. Medium-resolution solution structures for CR2 SCR 1-2, C3d, and their complex were determined by X-ray scattering and analytical ultracentrifugation. CR2 SCR 1-2 is monomeric. For CR2 SCR 1-2, its radius of gyration R(G) of 2.12(+/-0.05) nm, its maximum length of 10nm and its sedimentation coefficient s20,w(o) of 1.40(+/-0.03) S do not agree with those calculated from the crystal structures, and instead suggest an open structure. Computer modelling of the CR2 SCR1-2 solution structure was based on the structural randomisation of the eight-residue linker peptide joining SCR 1 and SCR 2 to give 9950 trial models. Comparisons with the X-ray scattering curve indicated that the most favoured arrangements for the two SCR domains corresponded to an open V-shaped structure with no contacts between the SCR domains. For C3d, X-ray scattering and sedimentation velocity experiments showed that it exists as a monomer-dimer equilibrium with a dissociation constant of 40 microM. The X-ray scattering curve for monomeric C3d gave an R(G) value of 1.95 nm, and this together with its s20,w(o) value of 3.17 S gave good agreement with the monomeric C3d crystal structure. Modelling of the C3d dimer gave good agreements with its scattering and ultracentrifugation parameters. For the complex, scattering and ultracentrifugation experiments showed that there was no dimerisation, indicating that the C3d dimerisation site was located close to the CR2 SCR 1-2 binding site. The R(G) value of 2.44(+/-0.1) nm, its length of 9 nm and its s20,w(o) value of 3.45(+/-0.01) S showed that its structure was not much more elongated than that of C3d. Calculations with 9950 models of CR2 SCR 1-2 bound to C3d through SCR 2 showed that SCR 1 formed an open V-shaped structure with SCR 2 and was capable of interacting with the surface of C3d. We conclude that the open V-shaped structures formed by CR2 SCR 1-2, both when free and when bound to C3d, are optimal for the formation of a tight two-domain interaction with its ligand C3d.

-	~~==About this Structure==~~	+	Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.,Gilbert HE, Eaton JT, Hannan JP, Holers VM, Perkins SJ J Mol Biol. 2005 Feb 25;346(3):859-73. Epub 2005 Jan 12. PMID:15713468<ref>PMID:15713468</ref>
-	~~[[1w2r]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1W2R OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:015713468</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Eaton, J T.]]
	[[Category: Gilbert, H E.]]		[[Category: Gilbert, H E.]]
	[[Category: Hannan, J P.]]		[[Category: Hannan, J P.]]

OCA at 04:26, 25 March 2013

OCA — Mon, 25 Mar 2013 04:26:21 GMT

←Older revision		Revision as of 04:26, 25 March 2013
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-	[[Image:1w2r.png\|left\|200px]]
-
	{{STRUCTURE_1w2r\| PDB=1w2r \| SCENE= }}		{{STRUCTURE_1w2r\| PDB=1w2r \| SCENE= }}
-
	===SOLUTION STRUCTURE OF CR2 SCR 1-2 BY X-RAY SCATTERING===		===SOLUTION STRUCTURE OF CR2 SCR 1-2 BY X-RAY SCATTERING===
-
	{{ABSTRACT_PUBMED_15713468}}		{{ABSTRACT_PUBMED_15713468}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:015713468</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015713468</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eaton, J T.]]		[[Category: Eaton, J T.]]

OCA: Protected "1w2r" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:46:59 GMT

Protected "1w2r" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:46, 5 January 2013

OCA at 11:46, 5 January 2013

OCA — Sat, 05 Jan 2013 11:46:57 GMT

←Older revision		Revision as of 11:46, 5 January 2013
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-	{{Seed}}
	[[Image:1w2r.png\|left\|200px]]		[[Image:1w2r.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w2r", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w2r\| PDB=1w2r \| SCENE= }}		{{STRUCTURE_1w2r\| PDB=1w2r \| SCENE= }}

	===SOLUTION STRUCTURE OF CR2 SCR 1-2 BY X-RAY SCATTERING===		===SOLUTION STRUCTURE OF CR2 SCR 1-2 BY X-RAY SCATTERING===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15713468}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15713468 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15713468}}		{{ABSTRACT_PUBMED_15713468}}

	==About this Structure==		==About this Structure==
-	~~1W2R~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA].	+	[[1w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2R OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15713468~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015713468</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eaton, J T.]]		[[Category: Eaton, J T.]]
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	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Thrombospondin type i repeat]]		[[Category: Thrombospondin type i repeat]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 09:57:59 2010''