1w3o - Revision history

OCA at 08:08, 15 November 2023

OCA — Wed, 15 Nov 2023 08:08:04 GMT

←Older revision		Revision as of 08:08, 15 November 2023
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	<StructureSection load='1w3o' size='340' side='right'caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1w3o' size='340' side='right'caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus~~ radiodurans~~" raj et al. 1960~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W3O FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1w3p\|1w3p]]~~, ~~[[1w3q\|1w3q]], [[1w3r\|1w3r]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [https://pdbe.org/1w3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [https://www.ebi.ac.uk/pdbsum/1w3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [https://pdbe.org/1w3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [https://www.ebi.ac.uk/pdbsum/1w3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9RW27_DEIRA Q9RW27_DEIRA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Micrococcus~~ radiodurans ~~raj et al. 1960~~]]	+	[[Category: Deinococcus radiodurans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kapp, U]]	+	[[Category: Kapp U]]
-	[[Category: Kozielski-Stuhrmann, S]]	+	[[Category: Kozielski-Stuhrmann S]]
-	[[Category: Leiros, H ~~K.S~~]]	+	[[Category: Leiros H-KS]]
-	[[Category: Leonard~~, G A~~]]	+	[[Category: Leonard GA]]
-	[[Category: McSweeney~~, S M~~]]	+	[[Category: McSweeney SM]]
-	[[Category: Terradot, L]]	+	[[Category: Terradot L]]
-	~~[[Category: 5-nitroimidazole resistance]]~~	+
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Catalytic mechanism]]~~	+
-	~~[[Category: Deinococcus radioduran]]~~	+
-	~~[[Category: Nim gene~~]]	+

OCA at 13:31, 13 October 2021

OCA — Wed, 13 Oct 2021 13:31:38 GMT

←Older revision		Revision as of 13:31, 13 October 2021
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	<StructureSection load='1w3o' size='340' side='right'caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1w3o' size='340' side='right'caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W3O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [~~http~~://pdbe.org/1w3o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w3o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [https://pdbe.org/1w3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [https://www.ebi.ac.uk/pdbsum/1w3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:16, 8 January 2020

OCA — Wed, 08 Jan 2020 10:16:43 GMT

←Older revision		Revision as of 10:16, 8 January 2020
Line 1:		Line 1:

	==Crystal structure of NimA from D. radiodurans==		==Crystal structure of NimA from D. radiodurans==
-	<StructureSection load='1w3o' size='340' side='right' caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='1w3o' size='340' side='right'caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Micrococcus radiodurans raj et al. 1960]]		[[Category: Micrococcus radiodurans raj et al. 1960]]
		+	[[Category: Large Structures]]
	[[Category: Kapp, U]]		[[Category: Kapp, U]]
	[[Category: Kozielski-Stuhrmann, S]]		[[Category: Kozielski-Stuhrmann, S]]

OCA at 07:22, 4 April 2018

OCA — Wed, 04 Apr 2018 07:22:32 GMT

←Older revision		Revision as of 07:22, 4 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of NimA from D. radiodurans==		==Crystal structure of NimA from D. radiodurans==
	<StructureSection load='1w3o' size='340' side='right' caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1w3o' size='340' side='right' caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://pdbe.org/1w3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://pdbe.org/1w3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w3o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w3o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:35, 7 February 2016

OCA — Sun, 07 Feb 2016 16:35:59 GMT

←Older revision		Revision as of 16:35, 7 February 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://pdbe.org/1w3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w3o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w3o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:01, 22 April 2015

OCA — Wed, 22 Apr 2015 07:01:23 GMT

←Older revision		Revision as of 07:01, 22 April 2015
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF NIMA FROM~~ D. ~~RADIODURANS~~==	+	==Crystal structure of NimA from D. radiodurans==
	<StructureSection load='1w3o' size='340' side='right' caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1w3o' size='340' side='right' caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Deinococcus_radiodurans Deinococcus~~ radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Deinococcus~~ radiodurans]]	+	[[Category: Micrococcus radiodurans raj et al. 1960]]
	[[Category: Kapp, U]]		[[Category: Kapp, U]]
	[[Category: Kozielski-Stuhrmann, S]]		[[Category: Kozielski-Stuhrmann, S]]
	[[Category: Leiros, H K.S]]		[[Category: Leiros, H K.S]]
	[[Category: Leonard, G A]]		[[Category: Leonard, G A]]
-	[[Category: ~~Mcsweeney~~, S M]]	+	[[Category: McSweeney, S M]]
	[[Category: Terradot, L]]		[[Category: Terradot, L]]
	[[Category: 5-nitroimidazole resistance]]		[[Category: 5-nitroimidazole resistance]]

OCA at 13:33, 6 January 2015

OCA — Tue, 06 Jan 2015 13:33:03 GMT

←Older revision		Revision as of 13:33, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Deinococcus radiodurans]]		[[Category: Deinococcus radiodurans]]
-	[[Category: Kapp, U.]]	+	[[Category: Kapp, U]]
-	[[Category: Kozielski-Stuhrmann, S.]]	+	[[Category: Kozielski-Stuhrmann, S]]
-	[[Category: Leiros, H K.S.]]	+	[[Category: Leiros, H K.S]]
-	[[Category: Leonard, G A.]]	+	[[Category: Leonard, G A]]
-	[[Category: Mcsweeney, S M.]]	+	[[Category: Mcsweeney, S M]]
-	[[Category: Terradot, L.]]	+	[[Category: Terradot, L]]
	[[Category: 5-nitroimidazole resistance]]		[[Category: 5-nitroimidazole resistance]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]

OCA at 21:50, 29 September 2014

OCA — Mon, 29 Sep 2014 21:50:22 GMT

←Older revision		Revision as of 21:50, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1w3o.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF NIMA FROM D. RADIODURANS==
		+	<StructureSection load='1w3o' size='340' side='right' caption='[[1w3o]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W3O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w3p\|1w3p]], [[1w3q\|1w3q]], [[1w3r\|1w3r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w3o RCSB], [http://www.ebi.ac.uk/pdbsum/1w3o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w3o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	5-Nitroimidazole-based antibiotics are compounds extensively used for treating infections in humans and animals caused by several important pathogens. They are administered as prodrugs, and their activation depends upon an anaerobic 1-electron reduction of the nitro group by a reduction pathway in the cells. Bacterial resistance toward these drugs is thought to be caused by decreased drug uptake and/or an altered reduction efficiency. One class of resistant strains, identified in Bacteroides, has been shown to carry Nim genes (NimA, -B, -C, -D, and -E), which encode for reductases that convert the nitro group on the antibiotic into a non-bactericidal amine. In this paper, we have described the crystal structure of NimA from Deinococcus radiodurans (drNimA) at 1.6 A resolution. We have shown that drNimA is a homodimer in which each monomer adopts a beta-barrel fold. We have identified the catalytically important His-71 along with the cofactor pyruvate and antibiotic binding sites, all of which are found at the monomer-monomer interface. We have reported three additional crystal structures of drNimA, one in which the antibiotic metronidazole is bound to the protein, one with pyruvate covalently bound to His-71, and one with lactate covalently bound to His-71. Based on these structures, a reaction mechanism has been proposed in which the 2-electron reduction of the antibiotic prevents accumulation of the toxic nitro radical. This mechanism suggests that Nim proteins form a new class of reductases, conferring resistance against 5-nitroimidazole-based antibiotics.

-	~~{{STRUCTURE_1w3o\| PDB=1w3o \| SCENE= }}~~	+	Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.,Leiros HK, Kozielski-Stuhrmann S, Kapp U, Terradot L, Leonard GA, McSweeney SM J Biol Chem. 2004 Dec 31;279(53):55840-9. Epub 2004 Oct 18. PMID:15492014<ref>PMID:15492014</ref>

-	~~===CRYSTAL STRUCTURE OF NIMA FROM D. RADIODURANS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15492014}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1w3o]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015492014<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Deinococcus radiodurans]]		[[Category: Deinococcus radiodurans]]
	[[Category: Kapp, U.]]		[[Category: Kapp, U.]]

OCA: Protected "1w3o" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:22:00 GMT

Protected "1w3o" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:22, 5 January 2013

OCA at 13:21, 5 January 2013

OCA — Sat, 05 Jan 2013 13:21:58 GMT

←Older revision		Revision as of 13:21, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1w3o.png\|left\|200px]]		[[Image:1w3o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w3o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w3o\| PDB=1w3o \| SCENE= }}		{{STRUCTURE_1w3o\| PDB=1w3o \| SCENE= }}

	===CRYSTAL STRUCTURE OF NIMA FROM D. RADIODURANS===		===CRYSTAL STRUCTURE OF NIMA FROM D. RADIODURANS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15492014}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15492014 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15492014}}		{{ABSTRACT_PUBMED_15492014}}

	==About this Structure==		==About this Structure==
-	~~1W3O~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA].	+	[[1w3o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3O OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15492014~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015492014</ref><references group="xtra"/>
	[[Category: Deinococcus radiodurans]]		[[Category: Deinococcus radiodurans]]
	[[Category: Kapp, U.]]		[[Category: Kapp, U.]]
Line 36:		Line 24:
	[[Category: Deinococcus radioduran]]		[[Category: Deinococcus radioduran]]
	[[Category: Nim gene]]		[[Category: Nim gene]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:09:34 2009''