1w42 - Revision history

OCA at 13:15, 13 December 2023

OCA — Wed, 13 Dec 2023 13:15:22 GMT

←Older revision		Revision as of 13:15, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1w42' size='340' side='right'caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1w42' size='340' side='right'caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35543 Atcc 35543~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_celer Thermococcus celer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1go0\|1go0]]~~, [[~~1go1~~\|~~1go1~~]]~~, [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [https://pdbe.org/1w42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [https://www.ebi.ac.uk/pdbsum/1w42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w42 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [https://pdbe.org/1w42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [https://www.ebi.ac.uk/pdbsum/1w42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w42 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RL30E_THECE RL30E_THECE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 35543]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Allen, M D~~]]	+	[[Category: Thermococcus celer]]
-	[[Category: ~~Bycroft, M~~]]	+	[[Category: Allen MD]]
-	[[Category: ~~Chan, S H~~]]	+	[[Category: Bycroft M]]
-	[[Category: ~~Lee, C F~~]]	+	[[Category: Chan SH]]
-	[[Category: Lee~~, K M~~]]	+	[[Category: Lee CF]]
-	[[Category: ~~Wong, K B~~]]	+	[[Category: Lee KM]]
-	[[Category: ~~Electrostatic interaction]]~~	+	[[Category: Wong KB]]
-	~~[[Category: Protein engineering]]~~	+
-	~~[[Category: Ribosomal protein]]~~	+
-	~~[[Category: Thermostability~~]]	+

OCA at 13:31, 13 October 2021

OCA — Wed, 13 Oct 2021 13:31:57 GMT

←Older revision		Revision as of 13:31, 13 October 2021
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	<StructureSection load='1w42' size='340' side='right'caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1w42' size='340' side='right'caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [~~http~~://pdbe.org/1w42 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w42 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w42 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [https://pdbe.org/1w42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [https://www.ebi.ac.uk/pdbsum/1w42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w42 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:02, 8 January 2020

OCA — Wed, 08 Jan 2020 10:02:09 GMT

←Older revision		Revision as of 10:02, 8 January 2020
Line 1:		Line 1:

	==T. celer L30e R92A variant==		==T. celer L30e R92A variant==
-	<StructureSection load='1w42' size='340' side='right' caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1w42' size='340' side='right'caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 35543]]		[[Category: Atcc 35543]]
		+	[[Category: Large Structures]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 07:09, 4 April 2018

OCA — Wed, 04 Apr 2018 07:09:33 GMT

←Older revision		Revision as of 07:09, 4 April 2018
Line 1:		Line 1:
-	==T. ~~CELER L30E~~ R92A ~~VARIANT~~==	+
		+	==T. celer L30e R92A variant==
	<StructureSection load='1w42' size='340' side='right' caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1w42' size='340' side='right' caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://pdbe.org/1w42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://pdbe.org/1w42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w42 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w42_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w42_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:57, 7 February 2016

OCA — Sun, 07 Feb 2016 21:57:59 GMT

←Older revision		Revision as of 21:57, 7 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w42 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:18, 10 September 2015

OCA — Thu, 10 Sep 2015 05:18:36 GMT

←Older revision		Revision as of 05:18, 10 September 2015
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	<StructureSection load='1w42' size='340' side='right' caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1w42' size='340' side='right' caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermococcus_celer Thermococcus celer~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35543 Atcc 35543]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://pdbe.org/1w42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w42" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermococcus celer~~]]	+	[[Category: Atcc 35543]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 12:13, 6 January 2015

OCA — Tue, 06 Jan 2015 12:13:57 GMT

←Older revision		Revision as of 12:13, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer Thermococcus celer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer Thermococcus celer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Thermococcus celer]]		[[Category: Thermococcus celer]]
-	[[Category: Allen, M D.]]	+	[[Category: Allen, M D]]
-	[[Category: Bycroft, M.]]	+	[[Category: Bycroft, M]]
-	[[Category: Chan, S H.]]	+	[[Category: Chan, S H]]
-	[[Category: Lee, C F.]]	+	[[Category: Lee, C F]]
-	[[Category: Lee, K M.]]	+	[[Category: Lee, K M]]
-	[[Category: Wong, K B.]]	+	[[Category: Wong, K B]]
	[[Category: Electrostatic interaction]]		[[Category: Electrostatic interaction]]
	[[Category: Protein engineering]]		[[Category: Protein engineering]]
	[[Category: Ribosomal protein]]		[[Category: Ribosomal protein]]
	[[Category: Thermostability]]		[[Category: Thermostability]]

OCA at 19:20, 29 September 2014

OCA — Mon, 29 Sep 2014 19:20:37 GMT

←Older revision		Revision as of 19:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1w42.~~png~~\|~~left~~\|200px]]	+	==T. CELER L30E R92A VARIANT==
		+	<StructureSection load='1w42' size='340' side='right' caption='[[1w42]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer Thermococcus celer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W42 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1go0\|1go0]], [[1go1\|1go1]], [[1h7m\|1h7m]], [[1w3e\|1w3e]], [[1w40\|1w40]], [[1w41\|1w41]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w42 RCSB], [http://www.ebi.ac.uk/pdbsum/1w42 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w42_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The origin of reduced heat capacity change of unfolding (DeltaC(p)) commonly observed in thermophilic proteins is controversial. The established theory that DeltaC(p) is correlated with change of solvent-accessible surface area cannot account for the large differences in DeltaC(p) observed for thermophilic and mesophilic homologous proteins, which are very similar in structures. We have determined the protein stability curves, which describe the temperature dependency of the free energy change of unfolding, for a thermophilic ribosomal protein L30e from Thermococcus celer, and its mesophilic homologue from yeast. Values of DeltaC(p), obtained by fitting the free energy change of unfolding to the Gibbs-Helmholtz equation, were 5.3 kJ mol(-1) K(-1) and 10.5 kJ mol(-1) K(-1) for T.celer and yeast L30e, respectively. We have created six charge-to-neutral mutants of T.celer L30e. Removal of charges at Glu6, Lys9, and Arg92 decreased the melting temperatures of T.celer L30e by approximately 3-9 degrees C, and the differences in melting temperatures were smaller with increasing concentration of salt. These results suggest that these mutations destabilize T.celer L30e by disrupting favorable electrostatic interactions. To determine whether electrostatic interactions contribute to the reduced DeltaC(p) of the thermophilic protein, we have determined DeltaC(p) for wild-type and mutant T.celer L30e by Gibbs-Helmholtz and by van't Hoff analyses. A concomitant increase in DeltaC(p) was observed for those charge-to-neutral mutants that destabilize T.celer L30e by removing favorable electrostatic interactions. The crystal structures of K9A, E90A, and R92A, were determined, and no structural change was observed. Taken together, our results support the conclusion that electrostatic interactions contribute to the reduced DeltaC(p) of T.celer L30e.

-	~~{{STRUCTURE_1w42\| PDB=1w42 \| SCENE= }}~~	+	Electrostatic interactions contribute to reduced heat capacity change of unfolding in a thermophilic ribosomal protein l30e.,Lee CF, Allen MD, Bycroft M, Wong KB J Mol Biol. 2005 Apr 29;348(2):419-31. PMID:15811378<ref>PMID:15811378</ref>

-	~~===T. CELER L30E R92A VARIANT===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15811378}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1w42]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermococcus_celer Thermococcus celer]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015811378<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermococcus celer]]		[[Category: Thermococcus celer]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D.]]

OCA: Protected "1w42" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:20:35 GMT

Protected "1w42" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 5 January 2013

OCA at 12:20, 5 January 2013

OCA — Sat, 05 Jan 2013 12:20:32 GMT

←Older revision		Revision as of 12:20, 5 January 2013
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-	{{Seed}}
	[[Image:1w42.png\|left\|200px]]		[[Image:1w42.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1w42\| PDB=1w42 \| SCENE= }}		{{STRUCTURE_1w42\| PDB=1w42 \| SCENE= }}

	===T. CELER L30E R92A VARIANT===		===T. CELER L30E R92A VARIANT===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15811378}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_15811378}}		{{ABSTRACT_PUBMED_15811378}}

	==About this Structure==		==About this Structure==
-	~~1W42~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer Thermococcus celer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA].	+	[[1w42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_celer Thermococcus celer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W42 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15811378~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015811378</ref><references group="xtra"/>
	[[Category: Thermococcus celer]]		[[Category: Thermococcus celer]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D.]]
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	[[Category: Ribosomal protein]]		[[Category: Ribosomal protein]]
	[[Category: Thermostability]]		[[Category: Thermostability]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:46:19 2009''