1w4i - Revision history

OCA at 13:30, 9 May 2024

OCA — Thu, 09 May 2024 13:30:36 GMT

←Older revision		Revision as of 13:30, 9 May 2024
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	==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==		==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==
-	<StructureSection load='1w4i' size='340' side='right'caption='[[1w4i~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1w4i' size='340' side='right'caption='[[1w4i]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_51768 Atcc 51768~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4I FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [https://pdbe.org/1w4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [https://www.ebi.ac.uk/pdbsum/1w4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [https://pdbe.org/1w4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [https://www.ebi.ac.uk/pdbsum/1w4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZUR6_PYRAE Q8ZUR6_PYRAE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Dihydrolipoamide acetyltransferase\|Dihydrolipoamide acetyltransferase]]	+	*[[Dihydrolipoamide acetyltransferase 3D structures\|Dihydrolipoamide acetyltransferase 3D structures]]
	*[[Dihydrolipoamide dehydrogenase\|Dihydrolipoamide dehydrogenase]]		*[[Dihydrolipoamide dehydrogenase\|Dihydrolipoamide dehydrogenase]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 51768]]
-	[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allen~~, M D~~]]	+	[[Category: Pyrobaculum aerophilum]]
-	[[Category: Ferguson, N]]	+	[[Category: Allen MD]]
-	[[Category: Fersht~~, A R~~]]	+	[[Category: Ferguson N]]
-	[[Category: Johnson~~, C M~~]]	+	[[Category: Fersht AR]]
-	[[Category: Sato, S]]	+	[[Category: Johnson CM]]
-	[[Category: Schartau~~, P J~~]]	+	[[Category: Sato S]]
-	[[Category: Sharpe~~, T D]]~~	+	[[Category: Schartau PJ]]
-	~~[[Category: Homologue]]~~	+	[[Category: Sharpe TD]]
-	~~[[Category: Peripheral-subunit binding domain]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Ultrafast folding~~]]	+

OCA at 13:32, 13 October 2021

OCA — Wed, 13 Oct 2021 13:32:14 GMT

←Older revision		Revision as of 13:32, 13 October 2021
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	<StructureSection load='1w4i' size='340' side='right'caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w4i' size='340' side='right'caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_51768 Atcc 51768]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_51768 Atcc 51768]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4I FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [~~http~~://pdbe.org/1w4i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w4i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [https://pdbe.org/1w4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [https://www.ebi.ac.uk/pdbsum/1w4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:52, 8 January 2020

OCA — Wed, 08 Jan 2020 10:52:14 GMT

←Older revision		Revision as of 10:52, 8 January 2020
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	==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==		==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==
-	<StructureSection load='1w4i' size='340' side='right' caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1w4i' size='340' side='right'caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_51768 Atcc 51768]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_51768 Atcc 51768]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>
Line 37:		Line 37:
	[[Category: Atcc 51768]]		[[Category: Atcc 51768]]
	[[Category: Dihydrolipoyllysine-residue acetyltransferase]]		[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Ferguson, N]]		[[Category: Ferguson, N]]

OCA at 07:53, 4 April 2018

OCA — Wed, 04 Apr 2018 07:53:43 GMT

←Older revision		Revision as of 07:53, 4 April 2018
Line 1:		Line 1:
-	==~~PERIPHERAL~~-~~SUBUNIT BINDING DOMAINS FROM MESOPHILIC~~, ~~THERMOPHILIC~~, ~~AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST~~, ~~APPARENTLY TWO~~-~~STATE TRANSITIONS~~==	+
		+	==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==
	<StructureSection load='1w4i' size='340' side='right' caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w4i' size='340' side='right' caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://pdbe.org/1w4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://pdbe.org/1w4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w4i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:20, 12 September 2015

OCA — Sat, 12 Sep 2015 00:20:10 GMT

←Older revision		Revision as of 00:20, 12 September 2015
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	<StructureSection load='1w4i' size='340' side='right' caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1w4i' size='340' side='right' caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrobaculum_aerophilum Pyrobaculum aerophilum~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_51768 Atcc 51768]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://pdbe.org/1w4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w4i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Dihydrolipoamide acetyltransferase\|Dihydrolipoamide acetyltransferase]]		*[[Dihydrolipoamide acetyltransferase\|Dihydrolipoamide acetyltransferase]]
		+	*[[Dihydrolipoamide dehydrogenase\|Dihydrolipoamide dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 51768]]
	[[Category: Dihydrolipoyllysine-residue acetyltransferase]]		[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
-	[[Category: Pyrobaculum aerophilum]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Ferguson, N]]		[[Category: Ferguson, N]]

OCA at 13:14, 6 January 2015

OCA — Tue, 06 Jan 2015 13:14:58 GMT

←Older revision		Revision as of 13:14, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Dihydrolipoyllysine-residue acetyltransferase]]		[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
	[[Category: Pyrobaculum aerophilum]]		[[Category: Pyrobaculum aerophilum]]
-	[[Category: Allen, M D.]]	+	[[Category: Allen, M D]]
-	[[Category: Ferguson, N.]]	+	[[Category: Ferguson, N]]
-	[[Category: Fersht, A R.]]	+	[[Category: Fersht, A R]]
-	[[Category: Johnson, C M.]]	+	[[Category: Johnson, C M]]
-	[[Category: Sato, S.]]	+	[[Category: Sato, S]]
-	[[Category: Schartau, P J.]]	+	[[Category: Schartau, P J]]
-	[[Category: Sharpe, T D.]]	+	[[Category: Sharpe, T D]]
	[[Category: Homologue]]		[[Category: Homologue]]
	[[Category: Peripheral-subunit binding domain]]		[[Category: Peripheral-subunit binding domain]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Ultrafast folding]]		[[Category: Ultrafast folding]]

OCA at 22:39, 28 September 2014

OCA — Sun, 28 Sep 2014 22:39:05 GMT

←Older revision		Revision as of 22:39, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1w4i.~~png~~\|~~left~~\|200px]]	+	==PERIPHERAL-SUBUNIT BINDING DOMAINS FROM MESOPHILIC, THERMOPHILIC, AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST, APPARENTLY TWO-STATE TRANSITIONS==
		+	<StructureSection load='1w4i' size='340' side='right' caption='[[1w4i]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W4I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w4e\|1w4e]], [[1w4f\|1w4f]], [[1w4h\|1w4h]], [[1w4j\|1w4j]], [[1w4k\|1w4k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w4i RCSB], [http://www.ebi.ac.uk/pdbsum/1w4i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined the solution structures, equilibrium properties and ultra-fast folding kinetics for three bacterial homologues of the peripheral subunit-binding domain (PSBD) family. The mesophilic homologue, BBL, was less stable than the thermophilic and hyper-thermophilic variants (E3BD and POB, respectively). The broad unfolding transitions of each PSBD, when probed by different techniques, were essentially superimposable, consistent with co-operative denaturation. Temperature-jump and continuous-flow fluorescence methods were used to measure the folding kinetics for E3BD, POB and BBL. E3BD folded fairly rapidly at 298K (folding half-time approximately 25 micros) and BBL and POB folded even faster (folding half-times approximately 3-5 micros). The variations in equilibrium and kinetic behaviour observed for the PSBD family resembles that of the homeodomain family, where the folding pattern changes from apparent two-state transitions to multi-state kinetics as the denatured state becomes more structured. The faster folding of POB may be a consequence of its higher propensity to form helical structure in the region corresponding to the folding nucleus of E3BD. The ultra-fast folding of BBL appears to be a consequence of residual structure in the denatured ensemble, as with engrailed homeodomain. We discuss issues concerning "one-state", downhill folding, and find no evidence for, and strong evidence against, it occurring in these PSBDs. The shorter construct used previously for BBL was destabilized significantly and the stability further perturbed by the introduction of fluorescent probes. Thermal titrations for 11 side-chains scattered around the protein, when probed by (13)C-NMR experiments, could be fit globally to a common co-operative transition.

-	~~{{STRUCTURE_1w4i\| PDB=1w4i \| SCENE= }}~~	+	Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family.,Ferguson N, Sharpe TD, Schartau PJ, Sato S, Allen MD, Johnson CM, Rutherford TJ, Fersht AR J Mol Biol. 2005 Oct 21;353(2):427-46. PMID:16168437<ref>PMID:16168437</ref>

-	~~===PERIPHERAL-SUBUNIT BINDING DOMAINS FROM MESOPHILIC~~, ~~THERMOPHILIC, AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST, APPARENTLY TWO-STATE TRANSITIONS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16168437}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1w4i]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA].~~	+

	==See Also==		==See Also==
	*[[Dihydrolipoamide acetyltransferase\|Dihydrolipoamide acetyltransferase]]		*[[Dihydrolipoamide acetyltransferase\|Dihydrolipoamide acetyltransferase]]
-	*[[Pyruvate dehydrogenase\|Pyruvate dehydrogenase]]	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:016168437<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Dihydrolipoyllysine-residue acetyltransferase]]		[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
	[[Category: Pyrobaculum aerophilum]]		[[Category: Pyrobaculum aerophilum]]

OCA at 21:47, 20 October 2012

OCA — Sat, 20 Oct 2012 21:47:24 GMT

←Older revision		Revision as of 21:47, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1w4i]] is a 1 chain structure ~~of [[Dihydrolipoamide acetyltransferase]] and [[Pyruvate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA].	+	[[1w4i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA].

	==See Also==		==See Also==

OCA: Protected "1w4i" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 14:18:03 GMT

Protected "1w4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:18, 27 July 2012

OCA at 14:18, 27 July 2012

OCA — Fri, 27 Jul 2012 14:18:02 GMT

←Older revision		Revision as of 14:18, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1w4i.png\|left\|200px]]		[[Image:1w4i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w4i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w4i\| PDB=1w4i \| SCENE= }}		{{STRUCTURE_1w4i\| PDB=1w4i \| SCENE= }}

	===PERIPHERAL-SUBUNIT BINDING DOMAINS FROM MESOPHILIC, THERMOPHILIC, AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST, APPARENTLY TWO-STATE TRANSITIONS===		===PERIPHERAL-SUBUNIT BINDING DOMAINS FROM MESOPHILIC, THERMOPHILIC, AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST, APPARENTLY TWO-STATE TRANSITIONS===

		+	{{ABSTRACT_PUBMED_16168437}}

	==About this Structure==		==About this Structure==
-	~~1W4I~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA].	+	[[1w4i]] is a 1 chain structure of [[Dihydrolipoamide acetyltransferase]] and [[Pyruvate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4I OCA].
		+
		+	==See Also==
		+	*[[Dihydrolipoamide acetyltransferase\|Dihydrolipoamide acetyltransferase]]
		+	*[[Pyruvate dehydrogenase\|Pyruvate dehydrogenase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:016168437</ref><references group="xtra"/>
	[[Category: Dihydrolipoyllysine-residue acetyltransferase]]		[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
	[[Category: Pyrobaculum aerophilum]]		[[Category: Pyrobaculum aerophilum]]
Line 26:		Line 27:
	[[Category: Homologue]]		[[Category: Homologue]]
	[[Category: Peripheral-subunit binding domain]]		[[Category: Peripheral-subunit binding domain]]
		+	[[Category: Transferase]]
	[[Category: Ultrafast folding]]		[[Category: Ultrafast folding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:56:02 2009''