1w5k - Revision history

OCA at 13:31, 9 May 2024

OCA — Thu, 09 May 2024 13:31:08 GMT

←Older revision		Revision as of 13:31, 9 May 2024
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	<StructureSection load='1w5k' size='340' side='right'caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1w5k' size='340' side='right'caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5K FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [https://pdbe.org/1w5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [https://www.ebi.ac.uk/pdbsum/1w5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [https://pdbe.org/1w5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [https://www.ebi.ac.uk/pdbsum/1w5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ghadiri, M R~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Leman, L J~~]]	+	[[Category: Ghadiri MR]]
-	[[Category: ~~Stout, C D~~]]	+	[[Category: Leman LJ]]
-	[[Category: ~~Yadav, M K~~]]	+	[[Category: Stout CD]]
-	[[Category: ~~Antiparallel four helix bundle]]~~	+	[[Category: Yadav MK]]
-	~~[[Category: Four helix bundle~~]]	+

OCA at 10:30, 17 February 2021

OCA — Wed, 17 Feb 2021 10:30:19 GMT

←Older revision		Revision as of 10:30, 17 February 2021
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	<StructureSection load='1w5k' size='340' side='right'caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1w5k' size='340' side='right'caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W5K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5K FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [~~http~~://pdbe.org/1w5k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w5k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [https://pdbe.org/1w5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [https://www.ebi.ac.uk/pdbsum/1w5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[~~Gcn4~~\|~~Gcn4~~]]	+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:47, 10 May 2019

OCA — Fri, 10 May 2019 11:47:55 GMT

←Older revision		Revision as of 11:47, 10 May 2019
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	==AN ANTI-PARALLEL FOUR HELIX BUNDLE==		==AN ANTI-PARALLEL FOUR HELIX BUNDLE==
-	<StructureSection load='1w5k' size='340' side='right' caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='1w5k' size='340' side='right'caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5K FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5K FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/1w5k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/1w5k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1w5k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1w5k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ghadiri, M R]]		[[Category: Ghadiri, M R]]
	[[Category: Leman, L J]]		[[Category: Leman, L J]]

OCA at 11:48, 6 November 2017

OCA — Mon, 06 Nov 2017 11:48:36 GMT

←Older revision		Revision as of 11:48, 6 November 2017
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	</div>		</div>
	<div class="pdbe-citations 1w5k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1w5k" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:35, 3 August 2017

OCA — Thu, 03 Aug 2017 11:35:30 GMT

←Older revision		Revision as of 11:35, 3 August 2017
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		+
	==AN ANTI-PARALLEL FOUR HELIX BUNDLE==		==AN ANTI-PARALLEL FOUR HELIX BUNDLE==
	<StructureSection load='1w5k' size='340' side='right' caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1w5k' size='340' side='right' caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://pdbe.org/1w5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://pdbe.org/1w5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w5k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:16, 11 September 2015

OCA — Fri, 11 Sep 2015 13:16:37 GMT

←Older revision		Revision as of 13:16, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://pdbe.org/1w5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w5k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:55, 6 January 2015

OCA — Tue, 06 Jan 2015 13:55:51 GMT

←Older revision		Revision as of 13:55, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5K FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ghadiri, M R.]]	+	[[Category: Ghadiri, M R]]
-	[[Category: Leman, L J.]]	+	[[Category: Leman, L J]]
-	[[Category: Stout, C D.]]	+	[[Category: Stout, C D]]
-	[[Category: Yadav, M K.]]	+	[[Category: Yadav, M K]]
	[[Category: Antiparallel four helix bundle]]		[[Category: Antiparallel four helix bundle]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]

OCA at 20:09, 29 September 2014

OCA — Mon, 29 Sep 2014 20:09:27 GMT

←Older revision		Revision as of 20:09, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1w5k.~~png~~\|~~left~~\|200px]]	+	==AN ANTI-PARALLEL FOUR HELIX BUNDLE==
		+	<StructureSection load='1w5k' size='340' side='right' caption='[[1w5k]], [[Resolution\|resolution]] 1.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W5K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYZ:PARA+ACETAMIDO+BENZOIC+ACID'>TYZ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ce9\|1ce9]], [[1dgc\|1dgc]], [[1env\|1env]], [[1fav\|1fav]], [[1gcl\|1gcl]], [[1gcm\|1gcm]], [[1gk6\|1gk6]], [[1gzl\|1gzl]], [[1ihq\|1ihq]], [[1ij0\|1ij0]], [[1ij1\|1ij1]], [[1ij2\|1ij2]], [[1ij3\|1ij3]], [[1kql\|1kql]], [[1ld4\|1ld4]], [[1llm\|1llm]], [[1nkn\|1nkn]], [[1piq\|1piq]], [[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb5\|1rb5]], [[1rb6\|1rb6]], [[1swi\|1swi]], [[1tmz\|1tmz]], [[1m6t\|1m6t]], [[1unt\|1unt]], [[1unu\|1unu]], [[1unv\|1unv]], [[1unw\|1unw]], [[1unx\|1unx]], [[1uny\|1uny]], [[1unz\|1unz]], [[1uo0\|1uo0]], [[1uo1\|1uo1]], [[1uo2\|1uo2]], [[1uo3\|1uo3]], [[1uo4\|1uo4]], [[1uo5\|1uo5]], [[1vzl\|1vzl]], [[1ysa\|1ysa]], [[1zii\|1zii]], [[1zij\|1zij]], [[1zik\|1zik]], [[1zil\|1zil]], [[1zim\|1zim]], [[1zta\|1zta]], [[2dgc\|2dgc]], [[2zta\|2zta]], [[1w5g\|1w5g]], [[1w5h\|1w5h]], [[1w5i\|1w5i]], [[1w5j\|1w5j]], [[1w5l\|1w5l]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w5k RCSB], [http://www.ebi.ac.uk/pdbsum/1w5k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/1w5k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A detailed understanding of the mechanisms by which particular amino acid sequences can give rise to more than one folded structure, such as for proteins that undergo large conformational changes or misfolding, is a long-standing objective of protein chemistry. Here, we describe the crystal structures of a single coiled-coil peptide in distinct parallel and antiparallel tetrameric configurations and further describe the parallel or antiparallel crystal structures of several related peptide sequences; the antiparallel tetrameric assemblies represent the first crystal structures of GCN4-derived peptides exhibiting such a configuration. Intriguingly, substitution of a single solvent-exposed residue enabled the parallel coiled-coil tetramer GCN4-pLI to populate the antiparallel configuration, suggesting that the two configurations are close enough in energy for subtle sequence changes to have important structural consequences. We present a structural analysis of the small changes to the helix register and side-chain conformations that accommodate the two configurations and have supplemented these results using solution studies and a molecular dynamics energetic analysis using a replica exchange methodology. Considering the previous examples of structural nonspecificity in coiled-coil peptides, the findings reported here not only emphasize the predisposition of the coiled-coil motif to adopt multiple configurations but also call attention to the associated risk that observed crytstal structures may not represent the only (or even the major) species present in solution.

-	~~{{STRUCTURE_1w5k\| PDB=1w5k \| SCENE= }}~~	+	Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution.,Yadav MK, Leman LJ, Price DJ, Brooks CL 3rd, Stout CD, Ghadiri MR Biochemistry. 2006 Apr 11;45(14):4463-73. PMID:16584182<ref>PMID:16584182</ref>

-	~~===AN ANTI-PARALLEL FOUR HELIX BUNDLE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16584182}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1w5k~~]] ~~is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016584182<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ghadiri, M R.]]		[[Category: Ghadiri, M R.]]
	[[Category: Leman, L J.]]		[[Category: Leman, L J.]]

OCA: Protected "1w5k" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:41:49 GMT

Protected "1w5k" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:41, 5 January 2013

OCA at 13:41, 5 January 2013

OCA — Sat, 05 Jan 2013 13:41:45 GMT

←Older revision		Revision as of 13:41, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1w5k.png\|left\|200px]]		[[Image:1w5k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w5k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w5k\| PDB=1w5k \| SCENE= }}		{{STRUCTURE_1w5k\| PDB=1w5k \| SCENE= }}

	===AN ANTI-PARALLEL FOUR HELIX BUNDLE===		===AN ANTI-PARALLEL FOUR HELIX BUNDLE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16584182}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16584182 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16584182}}		{{ABSTRACT_PUBMED_16584182}}

	==About this Structure==		==About this Structure==
-	~~1W5K~~ is a 4 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA].	+	[[1w5k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5K OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16584182~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016584182</ref><references group="xtra"/>
	[[Category: Ghadiri, M R.]]		[[Category: Ghadiri, M R.]]
-	[[Category: Leman, L.]]	+	[[Category: Leman, L J.]]
	[[Category: Stout, C D.]]		[[Category: Stout, C D.]]
	[[Category: Yadav, M K.]]		[[Category: Yadav, M K.]]
	[[Category: Antiparallel four helix bundle]]		[[Category: Antiparallel four helix bundle]]
-		+	[[Category: Four helix bundle]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 22:28:39 2009''~~	+