1w62 - Revision history

OCA at 13:17, 13 December 2023

OCA — Wed, 13 Dec 2023 13:17:12 GMT

←Older revision		Revision as of 13:17, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1w62' size='340' side='right'caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1w62' size='340' side='right'caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1W62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W62 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PYC:PYRROLE~~-~~2-CARBOXYLATE'>PYC</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1w61\|1w61]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PA45-A, Tc00.1047053506795.80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5693 TRYCR])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [https://pdbe.org/1w62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [https://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [~~http~~://pdbe.org/1w62 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PRCMA_TRYCC PRCMA_TRYCC]] Catalyzes the interconversion of L- and D-proline. Secreted isoform 1 contributes to parasite immune evasion by acting as a B-cell mitogen. Probably involved in parasite differentiation and infectivity.<ref>PMID:10932226</ref> <ref>PMID:16164548</ref> <ref>PMID:16446443</ref>	+	[https://www.uniprot.org/uniprot/PRCMA_TRYCC PRCMA_TRYCC] Catalyzes the interconversion of L- and D-proline. Secreted isoform 1 contributes to parasite immune evasion by acting as a B-cell mitogen. Probably involved in parasite differentiation and infectivity.<ref>PMID:10932226</ref> <ref>PMID:16164548</ref> <ref>PMID:16446443</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Proline racemase]]~~	+	[[Category: Trypanosoma cruzi strain CL Brener]]
-	~~[[Category: Trycr~~]]	+	[[Category: Alzari P]]
-	[[Category: Alzari, P]]	+	[[Category: Buschiazzo A]]
-	[[Category: Buschiazzo, A]]	+
-	~~[[Category: Alpha/beta domain]]~~	+
-	~~[[Category: B-cell mitogen]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Racemase]]~~	+
-	~~[[Category: Racemase pyridoxal phosphate-independent]]~~	+
-	~~[[Category: Stereo inversion~~]]	+

OCA at 07:42, 30 December 2020

OCA — Wed, 30 Dec 2020 07:42:32 GMT

←Older revision		Revision as of 07:42, 30 December 2020
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	==proline racemase in complex with one molecule of pyrrole-2-carboxylic acid (hemi form)==		==proline racemase in complex with one molecule of pyrrole-2-carboxylic acid (hemi form)==
-	<StructureSection load='1w62' size='340' side='right' caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1w62' size='340' side='right'caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1W62 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w61\|1w61]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA45-A, Tc00.1047053506795.80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA45-A, Tc00.1047053506795.80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Proline racemase]]		[[Category: Proline racemase]]
	[[Category: Trycr]]		[[Category: Trycr]]

OCA at 07:51, 14 June 2018

OCA — Thu, 14 Jun 2018 07:51:14 GMT

←Older revision		Revision as of 07:51, 14 June 2018
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA45-A, Tc00.1047053506795.80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRCMA_TRYCC PRCMA_TRYCC]] Catalyzes the interconversion of L- and D-proline. Secreted isoform 1 contributes to parasite immune evasion by acting as a B-cell mitogen. Probably involved in parasite differentiation and infectivity.<ref>PMID:10932226</ref> <ref>PMID:16164548</ref> <ref>PMID:16446443</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:36, 4 April 2018

OCA — Wed, 04 Apr 2018 07:36:44 GMT

←Older revision		Revision as of 07:36, 4 April 2018
Line 1:		Line 1:
-	==~~PROLINE RACEMASE IN COMPLEX WITH ONE MOLECULE OF PYRROLE~~-2-~~CARBOXYLIC ACID~~ (~~HEMI FORM~~)==	+
		+	==proline racemase in complex with one molecule of pyrrole-2-carboxylic acid (hemi form)==
	<StructureSection load='1w62' size='340' side='right' caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1w62' size='340' side='right' caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w62 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w62_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w62_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:23, 9 February 2016

OCA — Tue, 09 Feb 2016 15:23:46 GMT

←Older revision		Revision as of 15:23, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w62 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:33, 10 September 2015

OCA — Thu, 10 Sep 2015 23:33:15 GMT

←Older revision		Revision as of 23:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1w62' size='340' side='right' caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1w62' size='340' side='right' caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_cruzi Trypanosoma cruzi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W62 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://pdbe.org/1w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w62" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Proline racemase]]		[[Category: Proline racemase]]
-	[[Category: ~~Trypanosoma cruzi~~]]	+	[[Category: Trycr]]
	[[Category: Alzari, P]]		[[Category: Alzari, P]]
	[[Category: Buschiazzo, A]]		[[Category: Buschiazzo, A]]

OCA at 13:47, 6 January 2015

OCA — Tue, 06 Jan 2015 13:47:47 GMT

←Older revision		Revision as of 13:47, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W62 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W62 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Proline racemase]]		[[Category: Proline racemase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-	[[Category: Alzari, P.]]	+	[[Category: Alzari, P]]
-	[[Category: Buschiazzo, A.]]	+	[[Category: Buschiazzo, A]]
	[[Category: Alpha/beta domain]]		[[Category: Alpha/beta domain]]
	[[Category: B-cell mitogen]]		[[Category: B-cell mitogen]]

OCA at 19:08, 29 September 2014

OCA — Mon, 29 Sep 2014 19:08:22 GMT

←Older revision		Revision as of 19:08, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1w62.~~png~~\|~~left~~\|200px]]	+	==PROLINE RACEMASE IN COMPLEX WITH ONE MOLECULE OF PYRROLE-2-CARBOXYLIC ACID (HEMI FORM)==
		+	<StructureSection load='1w62' size='340' side='right' caption='[[1w62]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W62 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w61\|1w61]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline_racemase Proline racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.4 5.1.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w62 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w62 RCSB], [http://www.ebi.ac.uk/pdbsum/1w62 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w62_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amino acid racemases catalyze the stereoinversion of the chiral C alpha to produce the d-enantiomers that participate in biological processes, such as cell wall construction in prokaryotes. Within this large protein family, bacterial proline racemases have been extensively studied as a model of enzymes acting with a pyridoxal-phosphate-independent mechanism. Here we report the crystal structure of the proline racemase from the human parasite Trypanosoma cruzi (TcPRACA), a secreted enzyme that triggers host B cell polyclonal activation, which prevents specific humoral immune responses and is crucial for parasite evasion and fate. The enzyme is a homodimer, with each monomer folded in two symmetric alpha/beta subunits separated by a deep crevice. The structure of TcPRACA in complex with a transition-state analog, pyrrole-2-carboxylic acid, reveals the presence of one reaction center per monomer, with two Cys residues optimally located to perform acid/base catalysis through a carbanion stabilization mechanism. Mutation of the catalytic Cys residues abolishes the enzymatic activity but preserves the mitogenic properties of the protein. In contrast, inhibitor binding promotes the closure of the interdomain crevice and completely abrogates B cell proliferation, suggesting that the mitogenic properties of TcPRACA depend on the exposure of transient epitopes in the ligand-free enzyme.

-	~~{{STRUCTURE_1w62\| PDB=1w62 \| SCENE= }}~~	+	Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase.,Buschiazzo A, Goytia M, Schaeffer F, Degrave W, Shepard W, Gregoire C, Chamond N, Cosson A, Berneman A, Coatnoan N, Alzari PM, Minoprio P Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1705-10. Epub 2006 Jan 30. PMID:16446443<ref>PMID:16446443</ref>

-	~~===PROLINE RACEMASE IN COMPLEX WITH ONE MOLECULE OF PYRROLE-2-CARBOXYLIC ACID (HEMI FORM)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16446443}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1w62]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016446443<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Proline racemase]]		[[Category: Proline racemase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]

OCA: Protected "1w62" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:02:18 GMT

Protected "1w62" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 5 January 2013

OCA at 12:02, 5 January 2013

OCA — Sat, 05 Jan 2013 12:02:15 GMT

←Older revision		Revision as of 12:02, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1w62.png\|left\|200px]]		[[Image:1w62.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w62", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w62\| PDB=1w62 \| SCENE= }}		{{STRUCTURE_1w62\| PDB=1w62 \| SCENE= }}

	===PROLINE RACEMASE IN COMPLEX WITH ONE MOLECULE OF PYRROLE-2-CARBOXYLIC ACID (HEMI FORM)===		===PROLINE RACEMASE IN COMPLEX WITH ONE MOLECULE OF PYRROLE-2-CARBOXYLIC ACID (HEMI FORM)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16446443}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16446443 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16446443}}		{{ABSTRACT_PUBMED_16446443}}

	==About this Structure==		==About this Structure==
-	~~1W62~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA].	+	[[1w62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W62 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16446443~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016446443</ref><references group="xtra"/>
	[[Category: Proline racemase]]		[[Category: Proline racemase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
	[[Category: Alzari, P.]]		[[Category: Alzari, P.]]
	[[Category: Buschiazzo, A.]]		[[Category: Buschiazzo, A.]]
-	[[Category: B-cell mitogen~~,homodimer,alpha/beta domain~~]]	+	[[Category: Alpha/beta domain]]
-	[[Category: Racemase pyridoxal phosphate-independent~~,stereo inversion~~]]	+	[[Category: B-cell mitogen]]
-		+	[[Category: Homodimer]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Dec 21 15:24:29 2009''~~	+	[[Category: Racemase]]
		+	[[Category: Racemase pyridoxal phosphate-independent]]
		+	[[Category: Stereo inversion]]