1w7k - Revision history

OCA at 13:19, 13 December 2023

OCA — Wed, 13 Dec 2023 13:19:48 GMT

←Older revision		Revision as of 13:19, 13 December 2023
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	<StructureSection load='1w7k' size='340' side='right'caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1w7k' size='340' side='right'caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[1w78\|1w78]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [https://pdbe.org/1w7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [https://www.ebi.ac.uk/pdbsum/1w7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [https://pdbe.org/1w7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [https://www.ebi.ac.uk/pdbsum/1w7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI]] Conversion of folates to polyglutamate derivatives.	+	[https://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI] Conversion of folates to polyglutamate derivatives.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Dihydrofolate synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bamas-Jacques, N]]	+	[[Category: Bamas-Jacques N]]
-	[[Category: Debousker, G]]	+	[[Category: Debousker G]]
-	[[Category: Mathieu, M]]	+	[[Category: Mathieu M]]
-	[[Category: Mikol, V]]	+	[[Category: Mikol V]]
-	[[Category: Vincent, S]]	+	[[Category: Vincent S]]
-	[[Category: Viviani, F]]	+	[[Category: Viviani F]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Dhf]]~~	+
-	~~[[Category: Folate biosynthesis]]~~	+
-	~~[[Category: Folc]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Synthase~~]]	+

OCA at 13:33, 13 October 2021

OCA — Wed, 13 Oct 2021 13:33:49 GMT

←Older revision		Revision as of 13:33, 13 October 2021
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	<StructureSection load='1w7k' size='340' side='right'caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1w7k' size='340' side='right'caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1W7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w78\|1w78]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [~~http~~://pdbe.org/1w7k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1w7k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [https://pdbe.org/1w7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [https://www.ebi.ac.uk/pdbsum/1w7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI]] Conversion of folates to polyglutamate derivatives.	+	[[https://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI]] Conversion of folates to polyglutamate derivatives.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[~~Folypolyglutamate~~ synthase\|~~Folypolyglutamate~~ synthase]]	+	*[[Folylpolyglutamate synthase\|Folylpolyglutamate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 8 January 2020

OCA — Wed, 08 Jan 2020 10:03:48 GMT

←Older revision		Revision as of 10:03, 8 January 2020
Line 1:		Line 1:

	==E.coli FolC in complex with ADP, without folate substrate==		==E.coli FolC in complex with ADP, without folate substrate==
-	<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1w7k' size='340' side='right'caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
Line 40:		Line 40:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydrofolate synthase]]		[[Category: Dihydrofolate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Bamas-Jacques, N]]		[[Category: Bamas-Jacques, N]]
	[[Category: Debousker, G]]		[[Category: Debousker, G]]

OCA at 07:10, 4 April 2018

OCA — Wed, 04 Apr 2018 07:10:54 GMT

←Older revision		Revision as of 07:10, 4 April 2018
Line 1:		Line 1:
-	==E.~~COLI FOLC IN COMPLEX WITH~~ ADP, ~~WITHOUT FOLATE SUBSTRATE~~==	+
		+	==E.coli FolC in complex with ADP, without folate substrate==
	<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://pdbe.org/1w7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://pdbe.org/1w7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/1w7k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/1w7k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1w7k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1w7k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Folypolyglutamate synthase\|Folypolyglutamate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:51, 10 February 2016

OCA — Wed, 10 Feb 2016 00:51:59 GMT

←Older revision		Revision as of 00:51, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w7k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:43, 11 September 2015

OCA — Fri, 11 Sep 2015 03:43:48 GMT

←Older revision		Revision as of 03:43, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://pdbe.org/1w7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1w7k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydrofolate synthase]]		[[Category: Dihydrofolate synthase]]
-	[[Category: Escherichia coli]]
	[[Category: Bamas-Jacques, N]]		[[Category: Bamas-Jacques, N]]
	[[Category: Debousker, G]]		[[Category: Debousker, G]]

OCA at 10:38, 25 December 2014

OCA — Thu, 25 Dec 2014 10:38:55 GMT

←Older revision		Revision as of 10:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FOLC_ECOLI FOLC_ECOLI]] Conversion of folates to polyglutamate derivatives.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Dihydrofolate synthase]]		[[Category: Dihydrofolate synthase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Bamas-Jacques, N.]]	+	[[Category: Bamas-Jacques, N]]
-	[[Category: Debousker, G.]]	+	[[Category: Debousker, G]]
-	[[Category: Mathieu, M.]]	+	[[Category: Mathieu, M]]
-	[[Category: Mikol, V.]]	+	[[Category: Mikol, V]]
-	[[Category: Vincent, S.]]	+	[[Category: Vincent, S]]
-	[[Category: Viviani, F.]]	+	[[Category: Viviani, F]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Dhf]]		[[Category: Dhf]]
-	[[Category: Dihydrofolate synthase]]
	[[Category: Folate biosynthesis]]		[[Category: Folate biosynthesis]]
	[[Category: Folc]]		[[Category: Folc]]

OCA at 21:43, 29 September 2014

OCA — Mon, 29 Sep 2014 21:43:35 GMT

←Older revision		Revision as of 21:43, 29 September 2014
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-	[[~~Image:~~1w7k.~~png~~\|~~left~~\|200px]]	+	==E.COLI FOLC IN COMPLEX WITH ADP, WITHOUT FOLATE SUBSTRATE==
		+	<StructureSection load='1w7k' size='340' side='right' caption='[[1w7k]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W7K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w78\|1w78]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_synthase Dihydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.12 6.3.2.12] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w7k RCSB], [http://www.ebi.ac.uk/pdbsum/1w7k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/1w7k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In some bacteria, such as Escherichia coli, the addition of L-glutamate to dihydropteroate (dihydrofolate synthetase activity) and the subsequent additions of L-glutamate to tetrahydrofolate (folylpolyglutamate synthetase (FPGS) activity) are catalyzed by the same enzyme, FolC. The crystal structure of E. coli FolC is described in this paper. It showed strong similarities to that of the FPGS enzyme of Lactobacillus casei within the ATP binding site and the catalytic site, as do all other members of the Mur synthethase superfamily. FolC structure revealed an unexpected dihydropteroate binding site very different from the folate site identified previously in the FPGS structure. The relevance of this site is exemplified by the presence of phosphorylated dihydropteroate, a reaction intermediate in the DHFS reaction. L. casei FPGS is considered a relevant model for human FPGS. As such, the presence of a folate binding site in E. coli FolC, which is different from the one seen in FPGS enzymes, provides avenues for the design of specific inhibitors of this enzyme in antimicrobial therapy.

-	~~{{STRUCTURE_1w7k\| PDB=1w7k \| SCENE= }}~~	+	Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy.,Mathieu M, Debousker G, Vincent S, Viviani F, Bamas-Jacques N, Mikol V J Biol Chem. 2005 May 13;280(19):18916-22. Epub 2005 Feb 10. PMID:15705579<ref>PMID:15705579</ref>

-	~~===E.COLI FOLC IN COMPLEX WITH ADP~~, ~~WITHOUT FOLATE SUBSTRATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15705579}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1w7k]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015705579<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dihydrofolate synthase]]		[[Category: Dihydrofolate synthase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA: Protected "1w7k" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:09:18 GMT

Protected "1w7k" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 5 January 2013

OCA at 13:09, 5 January 2013

OCA — Sat, 05 Jan 2013 13:09:16 GMT

←Older revision		Revision as of 13:09, 5 January 2013
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-	{{Seed}}
	[[Image:1w7k.png\|left\|200px]]		[[Image:1w7k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1w7k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1w7k\| PDB=1w7k \| SCENE= }}		{{STRUCTURE_1w7k\| PDB=1w7k \| SCENE= }}

	===E.COLI FOLC IN COMPLEX WITH ADP, WITHOUT FOLATE SUBSTRATE===		===E.COLI FOLC IN COMPLEX WITH ADP, WITHOUT FOLATE SUBSTRATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15705579}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15705579 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15705579}}		{{ABSTRACT_PUBMED_15705579}}

	==About this Structure==		==About this Structure==
-	~~1W7K~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA].	+	[[1w7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7K OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15705579~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015705579</ref><references group="xtra"/>
	[[Category: Dihydrofolate synthase]]		[[Category: Dihydrofolate synthase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 40:		Line 28:
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: Synthase]]		[[Category: Synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:06:08 2009''