1wc6 - Revision history

OCA at 09:14, 9 May 2024

OCA — Thu, 09 May 2024 09:14:39 GMT

←Older revision		Revision as of 09:14, 9 May 2024
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	<StructureSection load='1wc6' size='340' side='right'caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1wc6' size='340' side='right'caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Artpt Artpt~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [https://pdbe.org/1wc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1wc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [https://pdbe.org/1wc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1wc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O32393_ARTPT O32393_ARTPT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenylate cyclase]]~~	+	[[Category: Arthrospira platensis]]
-	~~[[Category: Artpt~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buck, J]]	+	[[Category: Buck J]]
-	[[Category: Levin~~, L R~~]]	+	[[Category: Levin LR]]
-	[[Category: Litvin~~, T N~~]]	+	[[Category: Litvin TN]]
-	[[Category: Steegborn, C]]	+	[[Category: Steegborn C]]
-	[[Category: Wu, H]]	+	[[Category: Wu H]]
-	~~[[Category: Camp signaling]]~~	+
-	~~[[Category: Cyclase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Soluble adenylyl cyclase~~]]	+

OCA at 16:17, 27 October 2021

OCA — Wed, 27 Oct 2021 16:17:43 GMT

←Older revision		Revision as of 16:17, 27 October 2021
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	<StructureSection load='1wc6' size='340' side='right'caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1wc6' size='340' side='right'caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [~~http~~://pdbe.org/1wc6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wc6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [https://pdbe.org/1wc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1wc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:38, 22 January 2020

OCA — Wed, 22 Jan 2020 17:38:58 GMT

←Older revision		Revision as of 17:38, 22 January 2020
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	==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate==		==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate==
-	<StructureSection load='1wc6' size='340' side='right' caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='1wc6' size='340' side='right'caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Adenylyl cyclase\|Adenylyl cyclase]]	+	*[[3D Adenylyl cyclase 3D structures\|3D Adenylyl cyclase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Artpt]]		[[Category: Artpt]]
		+	[[Category: Large Structures]]
	[[Category: Buck, J]]		[[Category: Buck, J]]
	[[Category: Levin, L R]]		[[Category: Levin, L R]]

OCA at 16:23, 11 April 2018

OCA — Wed, 11 Apr 2018 16:23:27 GMT

←Older revision		Revision as of 16:23, 11 April 2018
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		+
	==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate==		==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate==
	<StructureSection load='1wc6' size='340' side='right' caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='1wc6' size='340' side='right' caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://pdbe.org/1wc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://pdbe.org/1wc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wc6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wc6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wc6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:17, 9 February 2016

OCA — Tue, 09 Feb 2016 15:17:54 GMT

←Older revision		Revision as of 15:17, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wc6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:30, 10 September 2015

OCA — Thu, 10 Sep 2015 23:30:18 GMT

←Older revision		Revision as of 23:30, 10 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://pdbe.org/1wc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wc6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:44, 6 January 2015

OCA — Tue, 06 Jan 2015 13:44:05 GMT

←Older revision		Revision as of 13:44, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Artpt]]		[[Category: Artpt]]
-	[[Category: Buck, J.]]	+	[[Category: Buck, J]]
-	[[Category: Levin, L R.]]	+	[[Category: Levin, L R]]
-	[[Category: Litvin, T N.]]	+	[[Category: Litvin, T N]]
-	[[Category: Steegborn, C.]]	+	[[Category: Steegborn, C]]
-	[[Category: Wu, H.]]	+	[[Category: Wu, H]]
	[[Category: Camp signaling]]		[[Category: Camp signaling]]
	[[Category: Cyclase]]		[[Category: Cyclase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Soluble adenylyl cyclase]]		[[Category: Soluble adenylyl cyclase]]

OCA at 05:28, 3 October 2014

OCA — Fri, 03 Oct 2014 05:28:08 GMT

←Older revision		Revision as of 05:28, 3 October 2014
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-	~~{{STRUCTURE_1wc6\| PDB=1wc6 \| SCENE= }}~~	+	==Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate==
-	===Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate===	+	<StructureSection load='1wc6' size='340' side='right' caption='[[1wc6]], [[Resolution\|resolution]] 2.51Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15619637}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WC6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TAT:ADENOSINE-5-RP-ALPHA-THIO-TRIPHOSPHATE'>TAT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wc0\|1wc0]], [[1wc1\|1wc1]], [[1wc3\|1wc3]], [[1wc4\|1wc4]], [[1wc5\|1wc5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wc6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wc6 RCSB], [http://www.ebi.ac.uk/pdbsum/1wc6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wc6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In an evolutionarily conserved signaling pathway, 'soluble' adenylyl cyclases (sACs) synthesize the ubiquitous second messenger cyclic adenosine 3',5'-monophosphate (cAMP) in response to bicarbonate and calcium signals. Here, we present crystal structures of a cyanobacterial sAC enzyme in complex with ATP analogs, calcium and bicarbonate, which represent distinct catalytic states of the enzyme. The structures reveal that calcium occupies the first ion-binding site and directly mediates nucleotide binding. The single ion-occupied, nucleotide-bound state defines a novel, open adenylyl cyclase state. In contrast, bicarbonate increases the catalytic rate by inducing marked active site closure and recruiting a second, catalytic ion. The phosphates of the bound substrate analogs are rearranged, which would facilitate product formation and release. The mechanisms of calcium and bicarbonate sensing define a reaction pathway involving active site closure and metal recruitment that may be universal for class III cyclases.

-	~~==About this Structure==~~	+	Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.,Steegborn C, Litvin TN, Levin LR, Buck J, Wu H Nat Struct Mol Biol. 2005 Jan;12(1):32-7. Epub 2004 Dec 26. PMID:15619637<ref>PMID:15619637</ref>
-	~~[[1wc6]] is a 3 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Artpt Artpt]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1WC6 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Adenylyl cyclase\|Adenylyl cyclase]]		*[[Adenylyl cyclase\|Adenylyl cyclase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015619637</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Artpt]]		[[Category: Artpt]]

OCA at 07:40, 5 February 2014

OCA — Wed, 05 Feb 2014 07:40:45 GMT

←Older revision		Revision as of 07:40, 5 February 2014
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-	[[Image:1wc6.png\|left\|200px]]
-
	{{STRUCTURE_1wc6\| PDB=1wc6 \| SCENE= }}		{{STRUCTURE_1wc6\| PDB=1wc6 \| SCENE= }}
-
	===Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate===		===Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate===
-
	{{ABSTRACT_PUBMED_15619637}}		{{ABSTRACT_PUBMED_15619637}}

	==About this Structure==		==About this Structure==
-	[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arthrospira_platensis Arthrospira platensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA].	+	[[1wc6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Artpt Artpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WC6 OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015619637</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015619637</ref><references group="xtra"/><references/>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
-	[[Category: ~~Arthrospira platensis~~]]	+	[[Category: Artpt]]
	[[Category: Buck, J.]]		[[Category: Buck, J.]]
	[[Category: Levin, L R.]]		[[Category: Levin, L R.]]

OCA at 13:09, 6 February 2013

OCA — Wed, 06 Feb 2013 13:09:48 GMT

←Older revision		Revision as of 13:09, 6 February 2013
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	{{STRUCTURE_1wc6\| PDB=1wc6 \| SCENE= }}		{{STRUCTURE_1wc6\| PDB=1wc6 \| SCENE= }}

-	===~~SOLUBLE ADENYLYL CYCLASE CYAC FROM~~ S. ~~PLATENSIS IN COMPLEX WITH RP~~-~~ATPALPHAS IN PRESENCE OF BICARBONATE~~===	+	===Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate===

	{{ABSTRACT_PUBMED_15619637}}		{{ABSTRACT_PUBMED_15619637}}