1wct - Revision history

OCA at 07:51, 12 July 2023

OCA — Wed, 12 Jul 2023 07:51:49 GMT

←Older revision		Revision as of 07:51, 12 July 2023
Line 1:		Line 1:

	==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==		==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==
-	<StructureSection load='1wct' size='340' side='right'caption='[[1wct~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1wct' size='340' side='right'caption='[[1wct]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [https://pdbe.org/1wct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [https://www.ebi.ac.uk/pdbsum/1wct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [https://pdbe.org/1wct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [https://www.ebi.ac.uk/pdbsum/1wct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CT5A_CONTE CT5A_CONTE]~~] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>	+	[https://www.uniprot.org/uniprot/CT5AS_CONTE CT5AS_CONTE] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	[[Category: Conus textile]]		[[Category: Conus textile]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baleja~~, J D~~]]	+	[[Category: Baleja JD]]
-	[[Category: Czerwiec, E]]	+	[[Category: Czerwiec E]]
-	[[Category: Furie, B]]	+	[[Category: Furie B]]
-	[[Category: Furie~~, B C~~]]	+	[[Category: Furie BC]]
-	[[Category: Hambe, B]]	+	[[Category: Hambe B]]
-	[[Category: Rigby~~, A C~~]]	+	[[Category: Rigby AC]]
-	[[Category: Stenflo, J]]	+	[[Category: Stenflo J]]
-	~~[[Category: Calcium channel blocker]]~~	+
-	~~[[Category: Gamma-carboxy glutamic acid]]~~	+
-	~~[[Category: Novel omega conotoxin~~]]	+

OCA at 06:29, 6 October 2021

OCA — Wed, 06 Oct 2021 06:29:57 GMT

←Older revision		Revision as of 06:29, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='1wct' size='340' side='right'caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1wct' size='340' side='right'caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WCT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GTH~~:3-O-~~GLUCOPYRANOSYL~~-~~THREONINE~~-[2-~~DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]~~'>~~GTH~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [~~http~~://pdbe.org/1wct PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wct PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [https://pdbe.org/1wct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [https://www.ebi.ac.uk/pdbsum/1wct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CT5A_CONTE CT5A_CONTE]] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>	+	[[https://www.uniprot.org/uniprot/CT5A_CONTE CT5A_CONTE]] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:14, 4 December 2019

OCA — Wed, 04 Dec 2019 11:14:19 GMT

←Older revision		Revision as of 11:14, 4 December 2019
Line 1:		Line 1:

	==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==		==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==
-	<StructureSection load='1wct' size='340' side='right' caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1wct' size='340' side='right'caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Conus textile]]		[[Category: Conus textile]]
		+	[[Category: Large Structures]]
	[[Category: Baleja, J D]]		[[Category: Baleja, J D]]
	[[Category: Czerwiec, E]]		[[Category: Czerwiec, E]]

OCA at 07:00, 29 November 2017

OCA — Wed, 29 Nov 2017 07:00:55 GMT

←Older revision		Revision as of 07:00, 29 November 2017
Line 1:		Line 1:
		+
	==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==		==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==
	<StructureSection load='1wct' size='340' side='right' caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1wct' size='340' side='right' caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://pdbe.org/1wct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://pdbe.org/1wct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:29, 10 September 2015

OCA — Thu, 10 Sep 2015 01:29:20 GMT

←Older revision		Revision as of 01:29, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://pdbe.org/1wct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CXET_CONTE CXET_CONTE~~]] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>	+	[[http://www.uniprot.org/uniprot/CT5A_CONTE CT5A_CONTE]] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wct" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:05, 24 December 2014

OCA — Wed, 24 Dec 2014 15:05:07 GMT

←Older revision		Revision as of 15:05, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXET_CONTE CXET_CONTE]] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Conus textile]]		[[Category: Conus textile]]
-	[[Category: Baleja, J D.]]	+	[[Category: Baleja, J D]]
-	[[Category: Czerwiec, E.]]	+	[[Category: Czerwiec, E]]
-	[[Category: Furie, B.]]	+	[[Category: Furie, B]]
-	[[Category: Furie, B C.]]	+	[[Category: Furie, B C]]
-	[[Category: Hambe, B.]]	+	[[Category: Hambe, B]]
-	[[Category: Rigby, A C.]]	+	[[Category: Rigby, A C]]
-	[[Category: Stenflo, J.]]	+	[[Category: Stenflo, J]]
	[[Category: Calcium channel blocker]]		[[Category: Calcium channel blocker]]
	[[Category: Gamma-carboxy glutamic acid]]		[[Category: Gamma-carboxy glutamic acid]]
	[[Category: Novel omega conotoxin]]		[[Category: Novel omega conotoxin]]

OCA at 06:50, 9 June 2014

OCA — Mon, 09 Jun 2014 06:50:08 GMT

←Older revision		Revision as of 06:50, 9 June 2014
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-	[[~~Image:~~1wct.~~png~~\|~~left~~\|~~200px~~]]	+	==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==
		+	<StructureSection load='1wct' size='340' side='right' caption='[[1wct]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTH:3-O-GLUCOPYRANOSYL-THREONINE-[2-DEOXY-2-ACETAMIDO-GLUCOPYRANOSIDE]'>GTH</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [http://www.ebi.ac.uk/pdbsum/1wct PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cone snails are gastropod mollusks of the genus Conus that live in tropical marine habitats. They are predators that paralyze their prey by injection of venom containing a plethora of small, conformationally constrained peptides (conotoxins). We report the identification, characterization, and structure of a gamma-carboxyglutamic acid-containing peptide, conotoxin epsilon-TxIX, isolated from the venom of the molluscivorous cone snail, Conus textile. The disulfide bonding pattern of the four cysteine residues, an unparalleled degree of posttranslational processing including bromination, hydroxylation, and glycosylation define a family of conotoxins that may target presynaptic Ca2+ channels or act on G protein-coupled presynaptic receptors via another mechanism. This conotoxin selectively reduces neurotransmitter release at an Aplysia cholinergic synapse by reducing the presynaptic influx of Ca2+ in a slow and reversible fashion. The three-dimensional structure, determined by two-dimensional 1H NMR spectroscopy, identifies an electronegative patch created by the side chains of two gamma-carboxyglutamic acid residues that extend outward from a cavernous cleft. The glycosylated threonine and hydroxylated proline enclose a localized hydrophobic region centered on the brominated tryptophan residue within the constrained intercysteine region.

-	~~{{STRUCTURE_1wct\| PDB=1wct \| SCENE= }}~~	+	A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx.,Rigby AC, Lucas-Meunier E, Kalume DE, Czerwiec E, Hambe B, Dahlqvist I, Fossier P, Baux G, Roepstorff P, Baleja JD, Furie BC, Furie B, Stenflo J Proc Natl Acad Sci U S A. 1999 May 11;96(10):5758-63. PMID:10318957<ref>PMID:10318957</ref>

-	~~===A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX~~, ~~NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10318957}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1wct]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Conus_textile Conus textile]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010318957<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Conus textile]]		[[Category: Conus textile]]
	[[Category: Baleja, J D.]]		[[Category: Baleja, J D.]]

OCA: Protected "1wct" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 17:30:20 GMT

Protected "1wct" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:30, 14 August 2012

OCA at 17:30, 14 August 2012

OCA — Tue, 14 Aug 2012 17:30:18 GMT

←Older revision		Revision as of 17:30, 14 August 2012
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-	{{Seed}}
	[[Image:1wct.png\|left\|200px]]		[[Image:1wct.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wct", creates the "Structure Box" on the page.
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	{{STRUCTURE_1wct\| PDB=1wct \| SCENE= }}		{{STRUCTURE_1wct\| PDB=1wct \| SCENE= }}

	===A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN===		===A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10318957}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10318957 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_10318957}}		{{ABSTRACT_PUBMED_10318957}}

	==About this Structure==		==About this Structure==
-	~~1WCT is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA].	+	[[1wct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA].

	==Reference==		==Reference==
-	A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx., Rigby AC, Lucas-Meunier E, Kalume DE, Czerwiec E, Hambe B, Dahlqvist I, Fossier P, Baux G, Roepstorff P, Baleja JD, Furie BC, Furie B, Stenflo J, Proc Natl Acad Sci U S A. 1999 May 11;96(10):5758-63. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~10318957 10318957]~~	+	<ref group="xtra">PMID:010318957</ref><references group="xtra"/>
	[[Category: Conus textile]]		[[Category: Conus textile]]
-	[[Category: Single protein]]
	[[Category: Baleja, J D.]]		[[Category: Baleja, J D.]]
	[[Category: Czerwiec, E.]]		[[Category: Czerwiec, E.]]
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	[[Category: Gamma-carboxy glutamic acid]]		[[Category: Gamma-carboxy glutamic acid]]
	[[Category: Novel omega conotoxin]]		[[Category: Novel omega conotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:18:36 2008''

OCA at 13:18, 27 July 2008

OCA — Sun, 27 Jul 2008 13:18:40 GMT

←Older revision		Revision as of 13:18, 27 July 2008
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-	[[Image:1wct.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1wct.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1wct\| PDB=1wct \| SCENE= }}		{{STRUCTURE_1wct\| PDB=1wct \| SCENE= }}

-	~~'''~~A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN~~'''~~	+	===A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN===


-	~~==Overview==~~	+	<!--
-	Cone snails are gastropod mollusks of the genus Conus that live in tropical marine habitats. They are predators that paralyze their prey by injection of venom containing a plethora of small, conformationally constrained peptides (conotoxins). We report the identification, characterization, and structure of a gamma-~~carboxyglutamic acid~~-~~containing peptide~~, ~~conotoxin epsilon-TxIX~~, ~~isolated from~~ the ~~venom of~~ the ~~molluscivorous cone snail, Conus textile~~. ~~The disulfide bonding pattern of the four cysteine residues~~, an unparalleled degree of posttranslational processing including bromination, hydroxylation, and glycosylation define a family of conotoxins that may target presynaptic Ca2+ channels or act on G protein-coupled presynaptic receptors via another mechanism. This conotoxin selectively reduces neurotransmitter release at an Aplysia cholinergic synapse by reducing the ~~presynaptic influx of Ca2+ in a slow and reversible fashion~~. ~~The three~~-~~dimensional structure, determined by two~~-dimensional 1H NMR spectroscopy, identifies an electronegative patch created by the side chains of two gamma-carboxyglutamic acid residues that extend outward from a cavernous cleft. The glycosylated threonine and hydroxylated proline enclose a localized hydrophobic region centered on the brominated tryptophan residue within the constrained intercysteine region.	+	The line below this paragraph, {{ABSTRACT_PUBMED_10318957}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10318957 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10318957}}

	==About this Structure==		==About this Structure==
-	1WCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA].	+	1WCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA].

	==Reference==		==Reference==
Line 32:		Line 36:
	[[Category: Gamma-carboxy glutamic acid]]		[[Category: Gamma-carboxy glutamic acid]]
	[[Category: Novel omega conotoxin]]		[[Category: Novel omega conotoxin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 13~~:28:49 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:18:36 2008''