1wi1 - Revision history

OCA at 13:40, 9 May 2024

OCA — Thu, 09 May 2024 13:40:25 GMT

←Older revision		Revision as of 13:40, 9 May 2024
Line 1:		Line 1:

	==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==		==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==
-	<StructureSection load='1wi1' size='340' side='right'caption='[[1wi1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1wi1' size='340' side='right'caption='[[1wi1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>KAZUSA cDNA hh10147 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [https://pdbe.org/1wi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [https://pdbe.org/1wi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAPS1_HUMAN CAPS1_HUMAN]] Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).	+	[https://www.uniprot.org/uniprot/CAPS1_HUMAN CAPS1_HUMAN] Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Izumi, K]]	+	[[Category: Izumi K]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Koshiba, S]]	+	[[Category: Koshiba S]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Tochio N]]
-	[[Category: Tochio, N]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+	[[Category: Yoneyama M]]
-	[[Category: Yoneyama, M]]	+	[[Category: Yoshida M]]
-	[[Category: Yoshida, M]]	+
-	~~[[Category: Endocytosis-exocytosis complex]]~~	+
-	~~[[Category: Ph domain]]~~	+
-	~~[[Category: Pip2 binding site]]~~	+
-	~~[[Category: Rsgi~~]]	+

OCA at 06:55, 2 March 2022

OCA — Wed, 02 Mar 2022 06:55:39 GMT

←Older revision		Revision as of 06:55, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1wi1' size='340' side='right'caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wi1' size='340' side='right'caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [~~http~~://pdbe.org/1wi1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [https://pdbe.org/1wi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAPS1_HUMAN CAPS1_HUMAN]] Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).	+	[[https://www.uniprot.org/uniprot/CAPS1_HUMAN CAPS1_HUMAN]] Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:46, 30 December 2020

OCA — Wed, 30 Dec 2020 07:46:45 GMT

←Older revision		Revision as of 07:46, 30 December 2020
Line 1:		Line 1:

	==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==		==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==
-	<StructureSection load='1wi1' size='340' side='right' caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1wi1' size='340' side='right'caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://pdbe.org/1wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://pdbe.org/1wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Izumi, K]]		[[Category: Izumi, K]]

OCA at 16:46, 11 April 2018

OCA — Wed, 11 Apr 2018 16:46:23 GMT

←Older revision		Revision as of 16:46, 11 April 2018
Line 1:		Line 1:
		+
	==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==		==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==
	<StructureSection load='1wi1' size='340' side='right' caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wi1' size='340' side='right' caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://pdbe.org/1wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://pdbe.org/1wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi1 ProSAT], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wi1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wi1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:26, 9 February 2016

OCA — Tue, 09 Feb 2016 21:26:51 GMT

←Older revision		Revision as of 21:26, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wi1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 02:11, 11 September 2015

OCA — Fri, 11 Sep 2015 02:11:51 GMT

←Older revision		Revision as of 02:11, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wi1' size='340' side='right' caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wi1' size='340' side='right' caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://pdbe.org/1wi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Izumi, K]]		[[Category: Izumi, K]]

OCA at 09:39, 25 December 2014

OCA — Thu, 25 Dec 2014 09:39:06 GMT

←Older revision		Revision as of 09:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAPS1_HUMAN CAPS1_HUMAN]] Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Izumi, K.]]	+	[[Category: Izumi, K]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Koshiba, S.]]	+	[[Category: Koshiba, S]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Tochio, N.]]	+	[[Category: Tochio, N]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
-	[[Category: Yoneyama, M.]]	+	[[Category: Yoneyama, M]]
-	[[Category: Yoshida, M.]]	+	[[Category: Yoshida, M]]
	[[Category: Endocytosis-exocytosis complex]]		[[Category: Endocytosis-exocytosis complex]]
	[[Category: Ph domain]]		[[Category: Ph domain]]
	[[Category: Pip2 binding site]]		[[Category: Pip2 binding site]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]

OCA at 20:44, 29 September 2014

OCA — Mon, 29 Sep 2014 20:44:45 GMT

←Older revision		Revision as of 20:44, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:1wi1.png\|left\|200px]]~~	+	==Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)==
-		+	<StructureSection load='1wi1' size='340' side='right' caption='[[1wi1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_1wi1\| PDB=1wi1 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WI1 FirstGlance]. <br>
-	===Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAZUSA cDNA hh10147 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wi1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1wi1 TOPSAN]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wi1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA: Protected "1wi1" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:35:39 GMT

Protected "1wi1" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:35, 5 January 2013

OCA at 11:35, 5 January 2013

OCA — Sat, 05 Jan 2013 11:35:36 GMT

←Older revision		Revision as of 11:35, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1wi1.png\|left\|200px]]		[[Image:1wi1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wi1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wi1\| PDB=1wi1 \| SCENE= }}		{{STRUCTURE_1wi1\| PDB=1wi1 \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~1WI1~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA].	+	[[1wi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI1 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
Line 25:		Line 18:
	[[Category: Yoneyama, M.]]		[[Category: Yoneyama, M.]]
	[[Category: Yoshida, M.]]		[[Category: Yoshida, M.]]
		+	[[Category: Endocytosis-exocytosis complex]]
	[[Category: Ph domain]]		[[Category: Ph domain]]
	[[Category: Pip2 binding site]]		[[Category: Pip2 binding site]]
Line 30:		Line 24:
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:48:17 2008''