1wiz - Revision history

OCA at 13:42, 9 May 2024

OCA — Thu, 09 May 2024 13:42:26 GMT

←Older revision		Revision as of 13:42, 9 May 2024
Line 1:		Line 1:

	==Solution structure of the first CUT domain of KIAA1034 protein==		==Solution structure of the first CUT domain of KIAA1034 protein==
-	<StructureSection load='1wiz' size='340' side='right'caption='[[1wiz~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1wiz' size='340' side='right'caption='[[1wiz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Kazusa cDNA fh00753 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [https://pdbe.org/1wiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [https://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [https://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [https://pdbe.org/1wiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [https://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [https://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[https://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).	+	[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[https://omim.org/entry/119540 119540]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>	+	[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hayashi, F]]	+	[[Category: Hayashi F]]
-	[[Category: Inoue, K]]	+	[[Category: Inoue K]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Nameki, S]]	+	[[Category: Nameki S]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Helix bundle]]~~	+
-	~~[[Category: Kiaa1034 protein]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Satb2~~]]	+

OCA at 06:56, 2 March 2022

OCA — Wed, 02 Mar 2022 06:56:48 GMT

←Older revision		Revision as of 06:56, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1wiz' size='340' side='right'caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wiz' size='340' side='right'caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [~~http~~://pdbe.org/1wiz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [https://pdbe.org/1wiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [https://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [https://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[~~http~~://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).	+	[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[https://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>	+	[[https://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wiz ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wiz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:47, 30 December 2020

OCA — Wed, 30 Dec 2020 07:47:43 GMT

←Older revision		Revision as of 07:47, 30 December 2020
Line 1:		Line 1:

	==Solution structure of the first CUT domain of KIAA1034 protein==		==Solution structure of the first CUT domain of KIAA1034 protein==
-	<StructureSection load='1wiz' size='340' side='right' caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1wiz' size='340' side='right'caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://pdbe.org/1wiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://pdbe.org/1wiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K]]		[[Category: Inoue, K]]

OCA at 16:34, 11 April 2018

OCA — Wed, 11 Apr 2018 16:34:30 GMT

←Older revision		Revision as of 16:34, 11 April 2018
Line 1:		Line 1:
		+
	==Solution structure of the first CUT domain of KIAA1034 protein==		==Solution structure of the first CUT domain of KIAA1034 protein==
	<StructureSection load='1wiz' size='340' side='right' caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wiz' size='340' side='right' caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://pdbe.org/1wiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://pdbe.org/1wiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wiz ProSAT], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wiz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wiz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wiz ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wiz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:05, 9 February 2016

OCA — Tue, 09 Feb 2016 12:05:06 GMT

←Older revision		Revision as of 12:05, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wiz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 22:04, 10 September 2015

OCA — Thu, 10 Sep 2015 22:04:33 GMT

←Older revision		Revision as of 22:04, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1wiz' size='340' side='right' caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wiz' size='340' side='right' caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://pdbe.org/1wiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Inoue, K]]		[[Category: Inoue, K]]

OCA at 13:54, 6 January 2015

OCA — Tue, 06 Jan 2015 13:54:50 GMT

←Older revision		Revision as of 13:54, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).		[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hayashi, F.]]	+	[[Category: Hayashi, F]]
-	[[Category: Inoue, K.]]	+	[[Category: Inoue, K]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Nameki, S.]]	+	[[Category: Nameki, S]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Helix bundle]]		[[Category: Helix bundle]]
	[[Category: Kiaa1034 protein]]		[[Category: Kiaa1034 protein]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Satb2]]		[[Category: Satb2]]
-	[[Category: Structural genomic]]

OCA at 22:01, 29 September 2014

OCA — Mon, 29 Sep 2014 22:01:52 GMT

←Older revision		Revision as of 22:01, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1wiz\| PDB=1wiz \| SCENE= }}~~	+	==Solution structure of the first CUT domain of KIAA1034 protein==
-	===Solution structure of the first CUT domain of KIAA1034 protein===	+	<StructureSection load='1wiz' size='340' side='right' caption='[[1wiz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WIZ FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref><ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA fh00753 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wiz RCSB], [http://www.ebi.ac.uk/pdbsum/1wiz PDBsum], [http://www.topsan.org/Proteins/RSGI/1wiz TOPSAN]</span></td></tr>
-	==Function==	+	<table>
-	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>	+	== Disease ==
-		+	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref> <ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
-	==~~About this Structure~~==	+	== Function ==
-	[[~~1wiz~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~1WIZ OCA~~].	+	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>
-		+	== Evolutionary Conservation ==
-	==~~Reference~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	<references ~~group="xtra"~~/><~~references~~/>	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wiz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 07:08, 25 March 2013

OCA — Mon, 25 Mar 2013 07:08:43 GMT

←Older revision		Revision as of 07:08, 25 March 2013
Line 1:		Line 1:
-	[[Image:1wiz.png\|left\|200px]]
-
	{{STRUCTURE_1wiz\| PDB=1wiz \| SCENE= }}		{{STRUCTURE_1wiz\| PDB=1wiz \| SCENE= }}
-
	===Solution structure of the first CUT domain of KIAA1034 protein===		===Solution structure of the first CUT domain of KIAA1034 protein===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Note=Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:[http://omim.org/entry/119540 119540]]. A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.<ref>PMID:12915443</ref><ref>PMID:17377962</ref> Note=A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SATB2_HUMAN SATB2_HUMAN]] Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<ref>PMID:14701874</ref>

	==About this Structure==		==About this Structure==
	[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA].		[[1wiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIZ OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA: Protected "1wiz" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:41:21 GMT

Protected "1wiz" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:41, 5 January 2013