1wkr - Revision history

OCA at 07:56, 25 October 2023

OCA — Wed, 25 Oct 2023 07:56:37 GMT

←Older revision		Revision as of 07:56, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1wkr' size='340' side='right'caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1wkr' size='340' side='right'caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=~~STA~~:~~STATINE~~'>~~STA~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [https://pdbe.org/1wkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [https://www.ebi.ac.uk/pdbsum/1wkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [https://pdbe.org/1wkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [https://www.ebi.ac.uk/pdbsum/1wkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CARP_IRPLA CARP_IRPLA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
-	*[[Proteinase\|Proteinase]]
	*[[Proteinase 3D structures\|Proteinase 3D structures]]		*[[Proteinase 3D structures\|Proteinase 3D structures]]
	== References ==		== References ==
Line 39:		Line 39:
	[[Category: Irpex lacteus]]		[[Category: Irpex lacteus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Polyporopepsin~~]]	+	[[Category: Streptomyces argenteolus subsp. toyonakensis]]
-	[[Category: Fujii, Y]]	+	[[Category: Fujii Y]]
-	[[Category: Fujimoto, Z]]	+	[[Category: Fujimoto Z]]
-	[[Category: Kaneko, S]]	+	[[Category: Kaneko S]]
-	[[Category: Kobayashi, H]]	+	[[Category: Kobayashi H]]
-	[[Category: Mizuno, H]]	+	[[Category: Mizuno H]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 16:20, 27 October 2021

OCA — Wed, 27 Oct 2021 16:20:33 GMT

←Older revision		Revision as of 16:20, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1wkr' size='340' side='right'caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1wkr' size='340' side='right'caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [~~http~~://pdbe.org/1wkr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wkr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [https://pdbe.org/1wkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [https://www.ebi.ac.uk/pdbsum/1wkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:04, 22 January 2020

OCA — Wed, 22 Jan 2020 18:04:38 GMT

←Older revision		Revision as of 18:04, 22 January 2020
Line 1:		Line 1:

	==Crystal structure of aspartic proteinase from Irpex lacteus==		==Crystal structure of aspartic proteinase from Irpex lacteus==
-	<StructureSection load='1wkr' size='340' side='right' caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='1wkr' size='340' side='right'caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKR FirstGlance]. <br>
Line 32:		Line 32:
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
	*[[Proteinase\|Proteinase]]		*[[Proteinase\|Proteinase]]
		+	*[[Proteinase 3D structures\|Proteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Irpex lacteus]]		[[Category: Irpex lacteus]]
		+	[[Category: Large Structures]]
	[[Category: Polyporopepsin]]		[[Category: Polyporopepsin]]
	[[Category: Fujii, Y]]		[[Category: Fujii, Y]]

OCA at 16:44, 11 April 2018

OCA — Wed, 11 Apr 2018 16:44:40 GMT

←Older revision		Revision as of 16:44, 11 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of aspartic proteinase from Irpex lacteus==		==Crystal structure of aspartic proteinase from Irpex lacteus==
	<StructureSection load='1wkr' size='340' side='right' caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1wkr' size='340' side='right' caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://pdbe.org/1wkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://pdbe.org/1wkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:54, 7 February 2016

OCA — Sun, 07 Feb 2016 19:54:45 GMT

←Older revision		Revision as of 19:54, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wkr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:31, 10 September 2015

OCA — Thu, 10 Sep 2015 04:31:16 GMT

←Older revision		Revision as of 04:31, 10 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://pdbe.org/1wkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wkr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:13, 6 January 2015

OCA — Tue, 06 Jan 2015 13:13:57 GMT

←Older revision		Revision as of 13:13, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKR FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Irpex lacteus]]		[[Category: Irpex lacteus]]
	[[Category: Polyporopepsin]]		[[Category: Polyporopepsin]]
-	[[Category: Fujii, Y.]]	+	[[Category: Fujii, Y]]
-	[[Category: Fujimoto, Z.]]	+	[[Category: Fujimoto, Z]]
-	[[Category: Kaneko, S.]]	+	[[Category: Kaneko, S]]
-	[[Category: Kobayashi, H.]]	+	[[Category: Kobayashi, H]]
-	[[Category: Mizuno, H.]]	+	[[Category: Mizuno, H]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 18:48, 29 September 2014

OCA — Mon, 29 Sep 2014 18:48:41 GMT

←Older revision		Revision as of 18:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wkr.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of aspartic proteinase from Irpex lacteus==
		+	<StructureSection load='1wkr' size='340' side='right' caption='[[1wkr]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyporopepsin Polyporopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.29 3.4.23.29] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkr RCSB], [http://www.ebi.ac.uk/pdbsum/1wkr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of Irpex lacteus aspartic proteinase (ILAP) in complex with pepstatin (a six amino acid residue peptide-like inhibitor) was determined at 1.3A resolution. ILAP is a pepsin-like enzyme, widely distributed in nature, with high milk-clotting activity relative to proteolytic activity. The overall structure was in good topological agreement with pepsin and other aspartic proteases. The structure and interaction pattern around the catalytic site were conserved, in agreement with the other aspartic proteinase/inhibitor complex structures reported previously. The high-resolution data also supported the transition state model, as proposed previously for the catalytic mechanism of aspartic proteinase. Unlike the other aspartic proteinases, ILAP was found to require hydrophobic residues either in the P(1) or P(1') site, and also in the P(4) and/or P(3) site(s) for secondary interactions. The inhibitor complex structure also revealed the substrate binding mechanism of ILAP at the P(3) and P(4) site of the substrate, where the inserted loop built up the unique hydrophobic pocket at the P(4) site.

-	~~{{STRUCTURE_1wkr\| PDB=1wkr \| SCENE= }}~~	+	Crystal structure of aspartic proteinase from Irpex lacteus in complex with inhibitor pepstatin.,Fujimoto Z, Fujii Y, Kaneko S, Kobayashi H, Mizuno H J Mol Biol. 2004 Aug 27;341(5):1227-35. PMID:15321718<ref>PMID:15321718</ref>

-	~~===Crystal structure~~ of ~~aspartic proteinase from Irpex lacteus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15321718}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1wkr]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Irpex_lacteus Irpex lacteus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA].~~	+

	==See Also==		==See Also==
	*[[Pepsin\|Pepsin]]		*[[Pepsin\|Pepsin]]
-		+	*[[Proteinase\|Proteinase]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:015321718<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Irpex lacteus]]		[[Category: Irpex lacteus]]
	[[Category: Polyporopepsin]]		[[Category: Polyporopepsin]]

OCA at 07:41, 20 October 2012

OCA — Sat, 20 Oct 2012 07:41:52 GMT

←Older revision		Revision as of 07:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1wkr]] is a 2 chain structure ~~of [[Pepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA].	+	[[1wkr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Irpex_lacteus Irpex lacteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKR OCA].

	==See Also==		==See Also==

OCA: Protected "1wkr" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 17:10:34 GMT

Protected "1wkr" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:10, 25 July 2012