1wkv - Revision history

OCA at 13:44, 9 May 2024

OCA — Thu, 09 May 2024 13:44:14 GMT

←Older revision		Revision as of 13:44, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1wkv' size='340' side='right'caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1wkv' size='340' side='right'caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aerpe Aerpe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1WKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix_K1 Aeropyrum pernix K1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~APE1586 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=272557 AERPE])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [~~http~~://pdbe.org/1wkv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wkv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [https://pdbe.org/1wkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [https://www.ebi.ac.uk/pdbsum/1wkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CYSO_AERPE CYSO_AERPE]] Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide.<ref>PMID:12644499</ref>	+	[https://www.uniprot.org/uniprot/CYSO_AERPE CYSO_AERPE] Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide.<ref>PMID:12644499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aerpe~~]]	+	[[Category: Aeropyrum pernix K1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ataka, M]]	+	[[Category: Ataka M]]
-	[[Category: Ishikawa, K]]	+	[[Category: Ishikawa K]]
-	[[Category: Mino, K]]	+	[[Category: Mino K]]
-	[[Category: Oda, Y]]	+	[[Category: Oda Y]]
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Open alpha/beta folding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:23, 6 January 2021

OCA — Wed, 06 Jan 2021 09:23:48 GMT

←Older revision		Revision as of 09:23, 6 January 2021
Line 1:		Line 1:

	==Crystal structure of O-phosphoserine sulfhydrylase==		==Crystal structure of O-phosphoserine sulfhydrylase==
-	<StructureSection load='1wkv' size='340' side='right' caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1wkv' size='340' side='right'caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpe Aerpe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpe Aerpe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WKV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272557 AERPE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272557 AERPE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://pdbe.org/1wkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://pdbe.org/1wkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Aerpe]]		[[Category: Aerpe]]
		+	[[Category: Large Structures]]
	[[Category: Ataka, M]]		[[Category: Ataka, M]]
	[[Category: Ishikawa, K]]		[[Category: Ishikawa, K]]

OCA at 16:00, 11 April 2018

OCA — Wed, 11 Apr 2018 16:00:20 GMT

←Older revision		Revision as of 16:00, 11 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of O-phosphoserine sulfhydrylase==		==Crystal structure of O-phosphoserine sulfhydrylase==
	<StructureSection load='1wkv' size='340' side='right' caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1wkv' size='340' side='right' caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272557 AERPE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272557 AERPE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://pdbe.org/1wkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://pdbe.org/1wkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:23, 10 February 2016

OCA — Wed, 10 Feb 2016 07:23:22 GMT

←Older revision		Revision as of 07:23, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wkv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:39, 11 September 2015

OCA — Fri, 11 Sep 2015 06:39:41 GMT

←Older revision		Revision as of 06:39, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wkv' size='340' side='right' caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1wkv' size='340' side='right' caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aeropyrum_pernix Aeropyrum pernix~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpe Aerpe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~56636 Aeropyrum pernix~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272557 AERPE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://pdbe.org/1wkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wkv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aeropyrum pernix~~]]	+	[[Category: Aerpe]]
	[[Category: Ataka, M]]		[[Category: Ataka, M]]
	[[Category: Ishikawa, K]]		[[Category: Ishikawa, K]]

OCA at 12:42, 25 December 2014

OCA — Thu, 25 Dec 2014 12:42:27 GMT

←Older revision		Revision as of 12:42, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 Aeropyrum pernix])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 Aeropyrum pernix])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYSO_AERPE CYSO_AERPE]] Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide.<ref>PMID:12644499</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Aeropyrum pernix]]		[[Category: Aeropyrum pernix]]
-	[[Category: Ataka, M.]]	+	[[Category: Ataka, M]]
-	[[Category: Ishikawa, K.]]	+	[[Category: Ishikawa, K]]
-	[[Category: Mino, K.]]	+	[[Category: Mino, K]]
-	[[Category: Oda, Y.]]	+	[[Category: Oda, Y]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
	[[Category: Open alpha/beta folding]]		[[Category: Open alpha/beta folding]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 19:49, 29 September 2014

OCA — Mon, 29 Sep 2014 19:49:57 GMT

←Older revision		Revision as of 19:49, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wkv.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of O-phosphoserine sulfhydrylase==
		+	<StructureSection load='1wkv' size='340' side='right' caption='[[1wkv]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APE1586 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 Aeropyrum pernix])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wkv RCSB], [http://www.ebi.ac.uk/pdbsum/1wkv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	O-Phosphoserine sulfhydrylase is a new enzyme found in a hyperthermophilic archaeon, Aeropyrum pernix K1. This enzyme catalyzes a novel cysteine synthetic reaction from O-phospho-l-serine and sulfide. The crystal structure of the enzyme was determined at 2.0A resolution using the method of multi-wavelength anomalous dispersion. A monomer consists of three domains, including an N-terminal domain with a new alpha/beta fold. The topology folds of the middle and C-terminal domains were similar to those of the O-acetylserine sulfhydrylase-A from Salmonella typhimurium and the cystathionine beta-synthase from human. The cofactor, pyridoxal 5'-phosphate, is bound in a cleft between the middle and C-terminal domains through a covalent linkage to Lys127. Based on the structure determined, O-phospho-l-serine could be rationally modeled into the active site of the enzyme. An enzyme-substrate complex model and a mutation experiment revealed that Arg297, unique to hyperthermophilic archaea, is one of the most crucial residues for O-phosphoserine sulfhydrylation activity. There are more hydrophobic areas and less electric charges at the dimer interface, compared to the S.typhimurium O-acetylserine sulfhydrylase.

-	~~{{STRUCTURE_1wkv\| PDB=1wkv \| SCENE= }}~~	+	Three-dimensional structure of a new enzyme, O-phosphoserine sulfhydrylase, involved in l-cysteine biosynthesis by a hyperthermophilic archaeon, Aeropyrum pernix K1, at 2.0A resolution.,Oda Y, Mino K, Ishikawa K, Ataka M J Mol Biol. 2005 Aug 12;351(2):334-44. PMID:16005886<ref>PMID:16005886</ref>

-	~~===Crystal structure~~ of ~~O-phosphoserine sulfhydrylase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16005886}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1wkv]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aeropyrum_pernix Aeropyrum pernix]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016005886<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Aeropyrum pernix]]		[[Category: Aeropyrum pernix]]
	[[Category: Ataka, M.]]		[[Category: Ataka, M.]]

OCA: Protected "1wkv" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 13:10:32 GMT

Protected "1wkv" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:10, 5 January 2013

OCA at 13:10, 5 January 2013

OCA — Sat, 05 Jan 2013 13:10:27 GMT

←Older revision		Revision as of 13:10, 5 January 2013
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-	{{Seed}}
	[[Image:1wkv.png\|left\|200px]]		[[Image:1wkv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wkv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wkv\| PDB=1wkv \| SCENE= }}		{{STRUCTURE_1wkv\| PDB=1wkv \| SCENE= }}

	===Crystal structure of O-phosphoserine sulfhydrylase===		===Crystal structure of O-phosphoserine sulfhydrylase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16005886}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16005886 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16005886}}		{{ABSTRACT_PUBMED_16005886}}

	==About this Structure==		==About this Structure==
-	~~1WKV~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA].	+	[[1wkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16005886~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016005886</ref><references group="xtra"/>
	[[Category: Aeropyrum pernix]]		[[Category: Aeropyrum pernix]]
	[[Category: Ataka, M.]]		[[Category: Ataka, M.]]
Line 31:		Line 19:
	[[Category: Homodimer]]		[[Category: Homodimer]]
	[[Category: Open alpha/beta folding]]		[[Category: Open alpha/beta folding]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 16:28:36 2009''~~	+

OCA at 14:28, 17 February 2009

OCA — Tue, 17 Feb 2009 14:28:37 GMT

←Older revision		Revision as of 14:28, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1WKV is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA].	+	1WKV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKV OCA].

	==Reference==		==Reference==
-	Three-dimensional structure of a new enzyme, O-phosphoserine sulfhydrylase, involved in l-cysteine biosynthesis by a hyperthermophilic archaeon, Aeropyrum pernix K1, at 2.0A resolution., Oda Y, Mino K, Ishikawa K, Ataka M, J Mol Biol. 2005 Aug 12;351(2):334-44. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16005886 16005886]~~	+	<ref group="xtra">PMID:16005886</ref><references group="xtra"/>
	[[Category: Aeropyrum pernix]]		[[Category: Aeropyrum pernix]]
-	[[Category: Single protein]]
	[[Category: Ataka, M.]]		[[Category: Ataka, M.]]
	[[Category: Ishikawa, K.]]		[[Category: Ishikawa, K.]]
Line 33:		Line 32:
	[[Category: Open alpha/beta folding]]		[[Category: Open alpha/beta folding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 23~~:08:~~47 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:28:36 2009''