1wpu - Revision history

OCA at 07:57, 25 October 2023

OCA — Wed, 25 Oct 2023 07:57:52 GMT

←Older revision		Revision as of 07:57, 25 October 2023
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	<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1vea\|1vea]]~~, ~~[[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [https://pdbe.org/1wpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [https://www.ebi.ac.uk/pdbsum/1wpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [https://pdbe.org/1wpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [https://www.ebi.ac.uk/pdbsum/1wpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HUTP_BACSU HUTP_BACSU]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.[HAMAP-Rule:MF_00779]	+	[https://www.uniprot.org/uniprot/HUTP_BACSU HUTP_BACSU] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.[HAMAP-Rule:MF_00779]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wpu ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wpu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	HutP is an L-histidine-activated RNA binding protein that regulates the expression of the histidine utilization (hut) operon in Bacillus subtilis by binding to cis-acting regulatory sequences on the hut mRNA. The crystal structure of HutP complexed with an L-histidine analog showed a novel fold; there are four antiparallel beta strands in the central region of each monomer, with two alpha helices each on the front and back. Two HutP monomers form a dimer, and three dimers are arranged in crystallographic 3-fold symmetry to form a hexamer. A histidine analog was located in between the two monomers of HutP, with the imidazole group of L-histidine hydrogen bonded to Glu81. An activation mechanism is proposed based on the identification of key residues of HutP. The HutP binding region in hut mRNA was defined: it consists of three UAG trinucleotide motifs separated by four spacer nucleotides. Residues of HutP potentially important for RNA binding were identified.
-
-	Crystal structure of activated HutP; an RNA binding protein that regulates transcription of the hut operon in Bacillus subtilis.,Kumarevel T, Fujimoto Z, Karthe P, Oda M, Mizuno H, Kumar PK Structure. 2004 Jul;12(7):1269-80. PMID:15242603<ref>PMID:15242603</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1wpu" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kumar~~, P K.R~~]]	+	[[Category: Kumar PKR]]
-	[[Category: Kumarevel~~, T S~~]]	+	[[Category: Kumarevel TS]]
-	[[Category: Mizuno, H]]	+	[[Category: Mizuno H]]
-	~~[[Category: Antitermination]]~~	+
-	~~[[Category: Hutp]]~~	+
-	~~[[Category: Hutp-rna complex]]~~	+
-	~~[[Category: Rna binding]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription-rna complex~~]]	+

OCA at 06:36, 10 November 2021

OCA — Wed, 10 Nov 2021 06:36:37 GMT

←Older revision		Revision as of 06:36, 10 November 2021
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	<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</div></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kumar, P K.R]]		[[Category: Kumar, P K.R]]

OCA at 09:04, 21 April 2021

OCA — Wed, 21 Apr 2021 09:04:20 GMT

←Older revision		Revision as of 09:04, 21 April 2021
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	<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [~~http~~://pdbe.org/1wpu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wpu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [https://pdbe.org/1wpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [https://www.ebi.ac.uk/pdbsum/1wpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HUTP_BACSU HUTP_BACSU]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.[HAMAP-Rule:MF_00779]	+	[[https://www.uniprot.org/uniprot/HUTP_BACSU HUTP_BACSU]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.[HAMAP-Rule:MF_00779]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:32, 17 July 2019

OCA — Wed, 17 Jul 2019 13:32:16 GMT

←Older revision		Revision as of 13:32, 17 July 2019
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	==Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA==		==Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA==
-	<StructureSection load='1wpu' size='340' side='right' caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='1wpu' size='340' side='right'caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus globigii migula 1900]]		[[Category: Bacillus globigii migula 1900]]
		+	[[Category: Large Structures]]
	[[Category: Kumar, P K.R]]		[[Category: Kumar, P K.R]]
	[[Category: Kumarevel, T S]]		[[Category: Kumarevel, T S]]

OCA at 09:33, 12 October 2017

OCA — Thu, 12 Oct 2017 09:33:31 GMT

←Older revision		Revision as of 09:33, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA==		==Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA==
	<StructureSection load='1wpu' size='340' side='right' caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='1wpu' size='340' side='right' caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://pdbe.org/1wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://pdbe.org/1wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wpu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:03, 11 September 2015

OCA — Fri, 11 Sep 2015 17:03:01 GMT

←Older revision		Revision as of 17:03, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wpu' size='340' side='right' caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='1wpu' size='340' side='right' caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://pdbe.org/1wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wpu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Kumar, P K.R]]		[[Category: Kumar, P K.R]]
	[[Category: Kumarevel, T S]]		[[Category: Kumarevel, T S]]

OCA at 19:21, 25 December 2014

OCA — Thu, 25 Dec 2014 19:21:42 GMT

←Older revision		Revision as of 19:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HUTP_BACSU HUTP_BACSU]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.[HAMAP-Rule:MF_00779]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Kumar, P K.R.]]	+	[[Category: Kumar, P K.R]]
-	[[Category: Kumarevel, T S.]]	+	[[Category: Kumarevel, T S]]
-	[[Category: Mizuno, H.]]	+	[[Category: Mizuno, H]]
	[[Category: Antitermination]]		[[Category: Antitermination]]
	[[Category: Hutp]]		[[Category: Hutp]]

OCA at 18:42, 29 September 2014

OCA — Mon, 29 Sep 2014 18:42:08 GMT

←Older revision		Revision as of 18:42, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wpu.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA==
		+	<StructureSection load='1wpu' size='340' side='right' caption='[[1wpu]], [[Resolution\|resolution]] 1.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vea\|1vea]], [[1wmq\|1wmq]], [[1wps\|1wps]], [[1wpt\|1wpt]], [[1wpv\|1wpv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wpu RCSB], [http://www.ebi.ac.uk/pdbsum/1wpu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HutP is an L-histidine-activated RNA binding protein that regulates the expression of the histidine utilization (hut) operon in Bacillus subtilis by binding to cis-acting regulatory sequences on the hut mRNA. The crystal structure of HutP complexed with an L-histidine analog showed a novel fold; there are four antiparallel beta strands in the central region of each monomer, with two alpha helices each on the front and back. Two HutP monomers form a dimer, and three dimers are arranged in crystallographic 3-fold symmetry to form a hexamer. A histidine analog was located in between the two monomers of HutP, with the imidazole group of L-histidine hydrogen bonded to Glu81. An activation mechanism is proposed based on the identification of key residues of HutP. The HutP binding region in hut mRNA was defined: it consists of three UAG trinucleotide motifs separated by four spacer nucleotides. Residues of HutP potentially important for RNA binding were identified.

-	~~{{STRUCTURE_1wpu\| PDB=1wpu \| SCENE= }}~~	+	Crystal structure of activated HutP; an RNA binding protein that regulates transcription of the hut operon in Bacillus subtilis.,Kumarevel T, Fujimoto Z, Karthe P, Oda M, Mizuno H, Kumar PK Structure. 2004 Jul;12(7):1269-80. PMID:15242603<ref>PMID:15242603</ref>

-	~~===Crystal Structure~~ of the ~~HutP antitermination complex bound to a single stranded region of hut mRNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15242603}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1wpu]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WPU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015242603<~~/~~ref~~><~~ref group="xtra">PMID:015273277</ref><references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Kumar, P K.R.]]		[[Category: Kumar, P K.R.]]

OCA at 12:24, 23 January 2013

OCA — Wed, 23 Jan 2013 12:24:16 GMT

←Older revision		Revision as of 12:24, 23 January 2013
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	[[Image:1wpu.png\|left\|200px]]		[[Image:1wpu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wpu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wpu\| PDB=1wpu \| SCENE= }}		{{STRUCTURE_1wpu\| PDB=1wpu \| SCENE= }}

	===Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA===		===Crystal Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15242603}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15242603 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15242603}}		{{ABSTRACT_PUBMED_15242603}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15242603~~</ref><ref group="xtra">PMID:~~15273277~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015242603</ref><ref group="xtra">PMID:015273277</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Kumar, P K.R.]]		[[Category: Kumar, P K.R.]]
Line 32:		Line 21:
	[[Category: Rna binding]]		[[Category: Rna binding]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	[[Category: Transcription/rna complex]]	+	[[Category: Transcription-rna complex]]

OCA: Protected "1wpu" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 19:03:50 GMT

Protected "1wpu" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:03, 14 March 2011