1wr1 - Revision history

OCA at 07:04, 27 September 2023

OCA — Wed, 27 Sep 2023 07:04:43 GMT

←Older revision		Revision as of 07:04, 27 September 2023
Line 1:		Line 1:

	==The complex structure of Dsk2p UBA with ubiquitin==		==The complex structure of Dsk2p UBA with ubiquitin==
-	<StructureSection load='1wr1' size='340' side='right'caption='[[1wr1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1wr1' size='340' side='right'caption='[[1wr1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1d3z\|1d3z]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [https://pdbe.org/1wr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [https://www.ebi.ac.uk/pdbsum/1wr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wr1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [~~http~~://pdbe.org/1wr1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wr1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wr1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~DSK2_YEAST DSK2_YEAST~~]~~] Involved~~, ~~with RAD23 in spindle pole body duplication~~. ~~Involved in~~ the ubiquitin-proteasome ~~proteolytic pathway~~.	+	[https://www.uniprot.org/uniprot/UBI4P_YEAST UBI4P_YEAST] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 30:

	==See Also==		==See Also==
-	*[[~~Ubiquitin~~\|~~Ubiquitin~~]]	+	*[[3D structures of ubiquitin\|3D structures of ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fujiwara, K]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Goda, N]]	+	[[Category: Fujiwara K]]
-	[[Category: Hiroaki, H]]	+	[[Category: Goda N]]
-	[[Category: Jee~~, J G~~]]	+	[[Category: Hiroaki H]]
-	[[Category: Ohno, A]]	+	[[Category: Jee JG]]
-	[[Category: Shirakawa, M]]	+	[[Category: Ohno A]]
-	[[Category: Tenno, T]]	+	[[Category: Shirakawa M]]
-	[[Category: Tochio, H]]	+	[[Category: Tenno T]]
-	[[Category: Kobayashi, H]]	+	[[Category: Tochio H]]
-	~~[[Category: Dsk2]]~~	+	[[Category: Kobayashi H]]
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Uba domain]]~~	+
-	~~[[Category: Uba-ubiquitin complex~~]]	+

OCA at 09:39, 9 September 2020

OCA — Wed, 09 Sep 2020 09:39:45 GMT

←Older revision		Revision as of 09:39, 9 September 2020
Line 1:		Line 1:

-	==The complex ~~sturcture~~ of Dsk2p UBA with ubiquitin==	+	==The complex structure of Dsk2p UBA with ubiquitin==
-	<StructureSection load='1wr1' size='340' side='right' caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1wr1' size='340' side='right'caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://pdbe.org/1wr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wr1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://pdbe.org/1wr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Fujiwara, K]]		[[Category: Fujiwara, K]]
	[[Category: Goda, N]]		[[Category: Goda, N]]

OCA at 16:45, 11 April 2018

OCA — Wed, 11 Apr 2018 16:45:47 GMT

←Older revision		Revision as of 16:45, 11 April 2018
Line 1:		Line 1:
		+
	==The complex sturcture of Dsk2p UBA with ubiquitin==		==The complex sturcture of Dsk2p UBA with ubiquitin==
	<StructureSection load='1wr1' size='340' side='right' caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wr1' size='340' side='right' caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://pdbe.org/1wr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://pdbe.org/1wr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wr1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wr1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wr1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:21, 9 February 2016

OCA — Tue, 09 Feb 2016 00:21:55 GMT

←Older revision		Revision as of 00:21, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wr1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:47, 10 September 2015

OCA — Thu, 10 Sep 2015 16:47:28 GMT

←Older revision		Revision as of 16:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1wr1' size='340' side='right' caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1wr1' size='340' side='right' caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://pdbe.org/1wr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wr1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Fujiwara, K]]		[[Category: Fujiwara, K]]
	[[Category: Goda, N]]		[[Category: Goda, N]]

OCA at 03:10, 25 December 2014

OCA — Thu, 25 Dec 2014 03:10:07 GMT

←Older revision		Revision as of 03:10, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DSK2_YEAST DSK2_YEAST]] Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Fujiwara, K.]]	+	[[Category: Fujiwara, K]]
-	[[Category: Goda, N.]]	+	[[Category: Goda, N]]
-	[[Category: Hiroaki, H.]]	+	[[Category: Hiroaki, H]]
-	[[Category: Jee, J G.]]	+	[[Category: Jee, J G]]
-	[[Category: Ohno, A.]]	+	[[Category: Ohno, A]]
-	[[Category: Shirakawa, M.]]	+	[[Category: Shirakawa, M]]
-	[[Category: Tenno, T.]]	+	[[Category: Tenno, T]]
-	[[Category: Tochio, H.]]	+	[[Category: Tochio, H]]
-	[[Category: Kobayashi, H.]]	+	[[Category: Kobayashi, H]]
	[[Category: Dsk2]]		[[Category: Dsk2]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Uba domain]]		[[Category: Uba domain]]
	[[Category: Uba-ubiquitin complex]]		[[Category: Uba-ubiquitin complex]]

OCA at 20:01, 28 September 2014

OCA — Sun, 28 Sep 2014 20:01:06 GMT

←Older revision		Revision as of 20:01, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wr1.~~png~~\|~~left~~\|200px]]	+	==The complex sturcture of Dsk2p UBA with ubiquitin==
		+	<StructureSection load='1wr1' size='340' side='right' caption='[[1wr1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WR1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3z\|1d3z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UBI4 (1224-1451) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), DSK2 (982-1120) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1wr1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wr1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ubiquitin-associated (UBA) domain is one of the most frequently occurring motifs that recognize ubiquitin tags. Dsk2p, a UBA-containing protein from Saccharomyces cerevisiae, is involved in the ubiquitin-proteasome proteolytic pathway and has been implicated in spindle pole duplication. Here we present the solution structure of the UBA domain of Dsk2p (Dsk2(UBA)) in complex with ubiquitin. The structure reveals that the UBA domain uses a mode of ubiquitin recognition that is similar to that of the CUE domain, another ubiquitin binding motif that shares low sequence homology but high structural similarity with UBA domains. These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.

-	~~{{STRUCTURE_1wr1\| PDB=1wr1 \| SCENE= }}~~	+	Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition.,Ohno A, Jee J, Fujiwara K, Tenno T, Goda N, Tochio H, Kobayashi H, Hiroaki H, Shirakawa M Structure. 2005 Apr;13(4):521-32. PMID:15837191<ref>PMID:15837191</ref>

-	~~===The complex sturcture~~ of ~~Dsk2p UBA with ubiquitin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15837191}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1wr1]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA].~~	+

	==See Also==		==See Also==
	*[[Ubiquitin\|Ubiquitin]]		*[[Ubiquitin\|Ubiquitin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015837191<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Fujiwara, K.]]		[[Category: Fujiwara, K.]]

OCA at 11:58, 20 October 2012

OCA — Sat, 20 Oct 2012 11:58:59 GMT

←Older revision		Revision as of 11:58, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1wr1]] is a 2 chain structure ~~of [[Ubiquitin]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA].	+	[[1wr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA].

	==See Also==		==See Also==

OCA at 07:14, 26 July 2012

OCA — Thu, 26 Jul 2012 07:14:30 GMT

←Older revision		Revision as of 07:14, 26 July 2012
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	[[Image:1wr1.png\|left\|200px]]		[[Image:1wr1.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_1wr1\| PDB=1wr1 \| SCENE= }}		{{STRUCTURE_1wr1\| PDB=1wr1 \| SCENE= }}

	===The complex sturcture of Dsk2p UBA with ubiquitin===		===The complex sturcture of Dsk2p UBA with ubiquitin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15837191}}, adds the Publication Abstract to the page
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	==See Also==		==See Also==
-	*[[Ubiquitin]]	+	*[[Ubiquitin\|Ubiquitin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15837191~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015837191</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Fujiwara, K.]]		[[Category: Fujiwara, K.]]

OCA: Protected "1wr1" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 09:34:17 GMT

Protected "1wr1" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:34, 26 December 2010