1wuv - Revision history

OCA at 08:00, 25 October 2023

OCA — Wed, 25 Oct 2023 08:00:21 GMT

←Older revision		Revision as of 08:00, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [https://pdbe.org/1wuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [https://www.ebi.ac.uk/pdbsum/1wuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [https://pdbe.org/1wuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [https://www.ebi.ac.uk/pdbsum/1wuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>	+	[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 38:
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Azevedo~~, W F~~]]	+	[[Category: Azevedo Jr WF]]
-	[[Category: Canduri, F]]	+	[[Category: Canduri F]]
-	[[Category: Cardoso~~, A L.H~~]]	+	[[Category: Cardoso ALH]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Cavada BS]]
-	[[Category: Delatorre, P]]	+	[[Category: Delatorre P]]
-	[[Category: Freitas~~, B T~~]]	+	[[Category: Freitas BT]]
-	[[Category: Moreno~~, F B.M B~~]]	+	[[Category: Moreno FBMB]]
-	[[Category: Rocha~~, B A.M~~]]	+	[[Category: Rocha BAM]]
-	[[Category: Sampaio~~, A H~~]]	+	[[Category: Sampaio AH]]
-	[[Category: Souza~~, E P]]~~	+	[[Category: Souza EP]]
-	~~[[Category: Beta sheet structure]]~~	+
-	~~[[Category: Native protein]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 10:30, 17 February 2021

OCA — Wed, 17 Feb 2021 10:30:50 GMT

←Older revision		Revision as of 10:30, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='1wuv' size='340' side='right'caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1wuv' size='340' side='right'caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WUV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [~~http~~://pdbe.org/1wuv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wuv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [https://pdbe.org/1wuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [https://www.ebi.ac.uk/pdbsum/1wuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>	+	[[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Concanavalin A\|Concanavalin A]]	+	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:13, 10 May 2019

OCA — Fri, 10 May 2019 14:13:28 GMT

←Older revision		Revision as of 14:13, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin==		==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin==
-	<StructureSection load='1wuv' size='340' side='right' caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1wuv' size='340' side='right'caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wuv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wuv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
		+	[[Category: Large Structures]]
	[[Category: Azevedo, W F]]		[[Category: Azevedo, W F]]
	[[Category: Canduri, F]]		[[Category: Canduri, F]]

OCA at 10:31, 3 August 2017

OCA — Thu, 03 Aug 2017 10:31:27 GMT

←Older revision		Revision as of 10:31, 3 August 2017
Line 1:		Line 1:
		+
	==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin==		==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin==
	<StructureSection load='1wuv' size='340' side='right' caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1wuv' size='340' side='right' caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://pdbe.org/1wuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://pdbe.org/1wuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:46, 9 February 2016

OCA — Tue, 09 Feb 2016 00:46:46 GMT

←Older revision		Revision as of 00:46, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wuv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:58, 10 September 2015

OCA — Thu, 10 Sep 2015 16:58:04 GMT

←Older revision		Revision as of 16:58, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://pdbe.org/1wuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wuv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:17, 25 December 2014

OCA — Thu, 25 Dec 2014 03:17:31 GMT

←Older revision		Revision as of 03:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
-	[[Category: Azevedo, W F.]]	+	[[Category: Azevedo, W F]]
-	[[Category: Canduri, F.]]	+	[[Category: Canduri, F]]
-	[[Category: Cardoso, A L.H.]]	+	[[Category: Cardoso, A L.H]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Freitas, B T.]]	+	[[Category: Freitas, B T]]
-	[[Category: Moreno, F B.M B.]]	+	[[Category: Moreno, F B.M B]]
-	[[Category: Rocha, B A.M.]]	+	[[Category: Rocha, B A.M]]
-	[[Category: Sampaio, A H.]]	+	[[Category: Sampaio, A H]]
-	[[Category: Souza, E P.]]	+	[[Category: Souza, E P]]
	[[Category: Beta sheet structure]]		[[Category: Beta sheet structure]]
	[[Category: Native protein]]		[[Category: Native protein]]
	[[Category: Plant protein]]		[[Category: Plant protein]]

OCA at 20:11, 28 September 2014

OCA — Sun, 28 Sep 2014 20:11:21 GMT

←Older revision		Revision as of 20:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1wuv.~~png\|left~~\|200px]]	+	==Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin==
		+	<StructureSection load='1wuv' size='340' side='right' caption='[[1wuv]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WUV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wuv RCSB], [http://www.ebi.ac.uk/pdbsum/1wuv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wuv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Lectins are mainly described as simple carbohydrate-binding proteins. Previous studies have tried to identify other binding sites, which possible recognize plant hormones, secondary metabolites, and isolated amino acid residues. We report the crystal structure of a lectin isolated from Canavalia gladiata seeds (CGL), describing a new binding pocket, which may be related to pathogen resistance activity in ConA-like lectins; a site where a non-protein amino-acid, alpha-aminobutyric acid (Abu), is bound. RESULTS: The overall structure of native CGL and complexed with alpha-methyl-mannoside and Abu have been refined at 2.3 A and 2.31 A resolution, respectively. Analysis of the electron density maps of the CGL structure shows clearly the presence of Abu, which was confirmed by mass spectrometry. CONCLUSION: The presence of Abu in a plant lectin structure strongly indicates the ability of lectins on carrying secondary metabolites. Comparison of the amino acids composing the site with other legume lectins revealed that this site is conserved, providing an evidence of the biological relevance of this site. This new action of lectins strengthens their role in defense mechanisms in plants.

-	~~{{STRUCTURE_1wuv\| PDB=1wuv \| SCENE= }}~~	+	Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules.,Delatorre P, Rocha BA, Souza EP, Oliveira TM, Bezerra GA, Moreno FB, Freitas BT, Santi-Gadelha T, Sampaio AH, Azevedo WF Jr, Cavada BS BMC Struct Biol. 2007 Aug 2;7:52. PMID:17683532<ref>PMID:17683532</ref>

-	~~===Crystal structure~~ of ~~native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17683532}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1wuv]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Canavalia_gladiata Canavalia gladiata]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA].~~	+

	==See Also==		==See Also==
	*[[Concanavalin A\|Concanavalin A]]		*[[Concanavalin A\|Concanavalin A]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017683532<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
	[[Category: Azevedo, W F.]]		[[Category: Azevedo, W F.]]

OCA at 12:02, 20 October 2012

OCA — Sat, 20 Oct 2012 12:02:56 GMT

←Older revision		Revision as of 12:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1wuv]] is a 4 chain structure ~~of [[Concanavalin A]]~~ with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA].	+	[[1wuv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUV OCA].

	==See Also==		==See Also==

OCA: Protected "1wuv" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 07:26:52 GMT

Protected "1wuv" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 26 July 2012