1wz5 - Revision history

OCA at 09:28, 6 December 2023

OCA — Wed, 06 Dec 2023 09:28:50 GMT

←Older revision		Revision as of 09:28, 6 December 2023
Line 1:		Line 1:

	==Solution structure of Pi1-3p==		==Solution structure of Pi1-3p==
-	<StructureSection load='1wz5' size='340' side='right'caption='[[1wz5~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1wz5' size='340' side='right'caption='[[1wz5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [https://pdbe.org/1wz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [https://pdbe.org/1wz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KAX61_PANIM KAX61_PANIM]] Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2. Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199. Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding onto rat brain synaptosomes.<ref>PMID:10931199</ref> <ref>PMID:8645186</ref> <ref>PMID:9001397</ref> <ref>PMID:9464266</ref>	+	[https://www.uniprot.org/uniprot/KAX61_PANIM KAX61_PANIM] Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2. Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199. Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding onto rat brain synaptosomes.<ref>PMID:10931199</ref> <ref>PMID:8645186</ref> <ref>PMID:9001397</ref> <ref>PMID:9464266</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 28:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Pandinus imperator]]		[[Category: Pandinus imperator]]
-	[[Category: Ferrat, G]]	+	[[Category: Ferrat G]]
-	~~[[Category: Ionic channel inhibitor]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 16:30, 27 October 2021

OCA — Wed, 27 Oct 2021 16:30:41 GMT

←Older revision		Revision as of 16:30, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1wz5' size='340' side='right'caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1wz5' size='340' side='right'caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [~~http~~://pdbe.org/1wz5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wz5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [https://pdbe.org/1wz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KAX61_PANIM KAX61_PANIM]] Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2. Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199. Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding onto rat brain synaptosomes.<ref>PMID:10931199</ref> <ref>PMID:8645186</ref> <ref>PMID:9001397</ref> <ref>PMID:9464266</ref>	+	[[https://www.uniprot.org/uniprot/KAX61_PANIM KAX61_PANIM]] Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2. Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199. Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding onto rat brain synaptosomes.<ref>PMID:10931199</ref> <ref>PMID:8645186</ref> <ref>PMID:9001397</ref> <ref>PMID:9464266</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:42, 22 January 2020

OCA — Wed, 22 Jan 2020 17:42:02 GMT

←Older revision		Revision as of 17:42, 22 January 2020
Line 1:		Line 1:

	==Solution structure of Pi1-3p==		==Solution structure of Pi1-3p==
-	<StructureSection load='1wz5' size='340' side='right' caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1wz5' size='340' side='right'caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Potassium channel toxin\|Potassium channel toxin]]	+	*[[Potassium channel toxin 3D structures\|Potassium channel toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pandinus imperator]]		[[Category: Pandinus imperator]]
	[[Category: Ferrat, G]]		[[Category: Ferrat, G]]
	[[Category: Ionic channel inhibitor]]		[[Category: Ionic channel inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 16:26, 11 April 2018

OCA — Wed, 11 Apr 2018 16:26:26 GMT

←Older revision		Revision as of 16:26, 11 April 2018
Line 1:		Line 1:
		+
	==Solution structure of Pi1-3p==		==Solution structure of Pi1-3p==
	<StructureSection load='1wz5' size='340' side='right' caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1wz5' size='340' side='right' caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [http://pdbe.org/1wz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1wz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [http://pdbe.org/1wz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1wz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:53, 11 September 2015

OCA — Fri, 11 Sep 2015 07:53:59 GMT

←Older revision		Revision as of 07:53, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1wz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [http://pdbe.org/1wz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1wz5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAX61_PANIM KAX61_PANIM]] Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2. Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage-independently inhibited in PubMed:9464266, but is not affected in PubMed:10931199. Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding onto rat brain synaptosomes.<ref>PMID:10931199</ref> <ref>PMID:8645186</ref> <ref>PMID:9001397</ref> <ref>PMID:9464266</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wz5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:51, 17 December 2014

OCA — Wed, 17 Dec 2014 13:51:25 GMT

←Older revision		Revision as of 13:51, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1wz5\| PDB~~=1wz5 \| ~~SCENE~~= }}	+	==Solution structure of Pi1-3p==
-	===~~Solution~~ structure ~~of Pi1~~-3p===	+	<StructureSection load='1wz5' size='340' side='right' caption='[[1wz5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_16247791}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZ5 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1wz5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Animal toxins are highly reticulated and structured polypeptides that adopt a limited number of folds. In scorpion species, the most represented fold is the alpha/beta scaffold in which an helical structure is connected to an antiparallel beta-sheet by two disulfide bridges. The intimate relationship existing between peptide reticulation and folding remains poorly understood. Here, we investigated the role of disulfide bridging on the 3D structure of HsTx1, a scorpion toxin potently active on Kv1.1 and Kv1.3 channels. This toxin folds along the classical alpha/beta scaffold but belongs to a unique family of short-chain, four disulfide-bridged toxins. Removal of the fourth disulfide bridge of HsTx1 does not affect its helical structure, whereas its two-stranded beta-sheet is altered from a twisted to a nontwisted configuration. This structural change in HsTx1 is accompanied by a marked decrease in Kv1.1 and Kv1.3 current blockage, and by alterations in the toxin to channel molecular contacts. In contrast, a similar removal of the fourth disulfide bridge of Pi1, another scorpion toxin from the same structural family, has no impact on its 3D structure, pharmacology, or channel interaction. These data highlight the importance of disulfide bridging in reaching the correct bioactive conformation of some toxins.

-	~~==About this Structure==~~	+	The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily.,Carrega L, Mosbah A, Ferrat G, Beeton C, Andreotti N, Mansuelle P, Darbon H, De Waard M, Sabatier JM Proteins. 2005 Dec 1;61(4):1010-23. PMID:16247791<ref>PMID:16247791</ref>
-	~~[[1wz5]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1WZ5 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Potassium channel toxin\|Potassium channel toxin]]		*[[Potassium channel toxin\|Potassium channel toxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016247791<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pandinus imperator]]		[[Category: Pandinus imperator]]
-	[[Category: Ferrat, G.]]	+	[[Category: Ferrat, G]]
	[[Category: Ionic channel inhibitor]]		[[Category: Ionic channel inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:25, 11 March 2013

OCA — Mon, 11 Mar 2013 09:25:43 GMT

←Older revision		Revision as of 09:25, 11 March 2013
Line 1:		Line 1:
-	[[Image:1wz5.png\|left\|200px]]
-
	{{STRUCTURE_1wz5\| PDB=1wz5 \| SCENE= }}		{{STRUCTURE_1wz5\| PDB=1wz5 \| SCENE= }}
-
	===Solution structure of Pi1-3p===		===Solution structure of Pi1-3p===
-
	{{ABSTRACT_PUBMED_16247791}}		{{ABSTRACT_PUBMED_16247791}}

	==About this Structure==		==About this Structure==
	[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].		[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].
		+
		+	==See Also==
		+	*[[Potassium channel toxin\|Potassium channel toxin]]

	==Reference==		==Reference==

OCA: Protected "1wz5" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 16:01:37 GMT

Protected "1wz5" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:01, 14 August 2012

OCA at 16:01, 14 August 2012

OCA — Tue, 14 Aug 2012 16:01:35 GMT

←Older revision		Revision as of 16:01, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1wz5.png\|left\|200px]]		[[Image:1wz5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wz5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wz5\| PDB=1wz5 \| SCENE= }}		{{STRUCTURE_1wz5\| PDB=1wz5 \| SCENE= }}

	===Solution structure of Pi1-3p===		===Solution structure of Pi1-3p===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16247791}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16247791 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16247791}}		{{ABSTRACT_PUBMED_16247791}}

	==About this Structure==		==About this Structure==
-	~~1WZ5 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].	+	[[1wz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].

	==Reference==		==Reference==
-	The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily., Carrega L, Mosbah A, Ferrat G, Beeton C, Andreotti N, Mansuelle P, Darbon H, De Waard M, Sabatier JM, Proteins. 2005 Dec 1;61(4):1010-23. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16247791 16247791]~~	+	<ref group="xtra">PMID:016247791</ref><references group="xtra"/>
	[[Category: Pandinus imperator]]		[[Category: Pandinus imperator]]
-	[[Category: Single protein]]
	[[Category: Ferrat, G.]]		[[Category: Ferrat, G.]]
	[[Category: Ionic channel inhibitor]]		[[Category: Ionic channel inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:26:12 2008''

OCA at 21:26, 28 July 2008

OCA — Mon, 28 Jul 2008 21:26:14 GMT

←Older revision		Revision as of 21:26, 28 July 2008
Line 1:		Line 1:
-	[[Image:1wz5.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1wz5.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1wz5\| PDB=1wz5 \| SCENE= }}		{{STRUCTURE_1wz5\| PDB=1wz5 \| SCENE= }}

-	~~'''~~Solution structure of Pi1-3p~~'''~~	+	===Solution structure of Pi1-3p===


-	~~==Overview==~~	+	<!--
-	~~Animal toxins are highly reticulated and structured polypeptides that adopt a limited number of folds. In scorpion species~~, the ~~most represented fold is~~ the ~~alpha~~/~~beta scaffold in which an helical structure is connected to an antiparallel beta-sheet by two disulfide bridges~~. ~~The intimate relationship existing between peptide reticulation and folding remains poorly understood~~. ~~Here~~, ~~we investigated~~ the ~~role of disulfide bridging on the 3D structure of HsTx1, a scorpion toxin potently active on Kv1~~.~~1 and Kv1.3 channels. This toxin folds along the classical alpha/beta scaffold but belongs to a unique family of short~~-~~chain, four disulfide~~-bridged toxins. Removal of the fourth disulfide bridge of HsTx1 does not affect its helical structure, whereas its two-stranded beta-sheet is altered from a twisted to a nontwisted configuration. This structural change in HsTx1 is accompanied by a marked decrease in Kv1.1 and Kv1.3 current blockage, and by alterations in the toxin to channel molecular contacts. In contrast, a similar removal of the fourth disulfide bridge of Pi1, another scorpion toxin from the same structural family, has no impact on its 3D structure, pharmacology, or channel interaction. These data highlight the importance of disulfide bridging in reaching the correct bioactive conformation of some toxins.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16247791}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16247791 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16247791}}

	==About this Structure==		==About this Structure==
-	1WZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].	+	1WZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].

	==Reference==		==Reference==
Line 25:		Line 29:
	[[Category: Ionic channel inhibitor]]		[[Category: Ionic channel inhibitor]]
	[[Category: Toxin]]		[[Category: Toxin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 14~~:20:20 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:26:12 2008''