1wzc - Revision history

OCA at 13:54, 9 May 2024

OCA — Thu, 09 May 2024 13:54:22 GMT

←Older revision		Revision as of 13:54, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='1wzc' size='340' side='right'caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1wzc' size='340' side='right'caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'pyrococcus_shinkaii' 'pyrococcus shinkaii'~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PH0926 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~53953 'Pyrococcus shinkaii'])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [https://pdbe.org/1wzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [https://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [https://pdbe.org/1wzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [https://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.	+	[https://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pyrococcus shinkaii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mannosyl-3-phosphoglycerate phosphatase~~]]	+	[[Category: Pyrococcus horikoshii]]
-	[[Category: Kawamura, T]]	+	[[Category: Kawamura T]]
-	[[Category: Tanaka, I]]	+	[[Category: Tanaka I]]
-	[[Category: Watanabe, N]]	+	[[Category: Watanabe N]]
-	~~[[Category: Haloacid dehalogenase like hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphatase~~]]	+

OCA at 06:37, 10 November 2021

OCA — Wed, 10 Nov 2021 06:37:50 GMT

←Older revision		Revision as of 06:37, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1wzc' size='340' side='right'caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1wzc' size='340' side='right'caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1WZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [~~http~~://pdbe.org/1wzc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [https://pdbe.org/1wzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [https://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.	+	[[https://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:32, 6 January 2021

OCA — Wed, 06 Jan 2021 09:32:56 GMT

←Older revision		Revision as of 09:32, 6 January 2021
Line 1:		Line 1:

	==Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate==		==Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate==
-	<StructureSection load='1wzc' size='340' side='right' caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1wzc' size='340' side='right'caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1WZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WZC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://pdbe.org/1wzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://pdbe.org/1wzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus shinkaii]]		[[Category: Pyrococcus shinkaii]]
		+	[[Category: Large Structures]]
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Kawamura, T]]		[[Category: Kawamura, T]]

OCA at 16:19, 11 April 2018

OCA — Wed, 11 Apr 2018 16:19:23 GMT

←Older revision		Revision as of 16:19, 11 April 2018
Line 1:		Line 1:
		+
	==Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate==		==Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate==
	<StructureSection load='1wzc' size='340' side='right' caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1wzc' size='340' side='right' caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://pdbe.org/1wzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://pdbe.org/1wzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wzc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wzc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wzc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:32, 11 September 2015

OCA — Fri, 11 Sep 2015 08:32:06 GMT

←Older revision		Revision as of 08:32, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1wzc' size='340' side='right' caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1wzc' size='340' side='right' caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_horikoshii Pyrococcus horikoshii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus ~~horikoshii~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://pdbe.org/1wzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1wzc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pyrococcus shinkaii]]
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
-	[[Category: Pyrococcus horikoshii]]
	[[Category: Kawamura, T]]		[[Category: Kawamura, T]]
	[[Category: Tanaka, I]]		[[Category: Tanaka, I]]

OCA at 13:54, 25 December 2014

OCA — Thu, 25 Dec 2014 13:54:46 GMT

←Older revision		Revision as of 13:54, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MPGP_PYRHO MPGP_PYRHO]] Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
-	[[Category: Kawamura, T.]]	+	[[Category: Kawamura, T]]
-	[[Category: Tanaka, I.]]	+	[[Category: Tanaka, I]]
-	[[Category: Watanabe, N.]]	+	[[Category: Watanabe, N]]
	[[Category: Haloacid dehalogenase like hydrolase]]		[[Category: Haloacid dehalogenase like hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]

OCA at 20:58, 29 September 2014

OCA — Mon, 29 Sep 2014 20:58:16 GMT

←Older revision		Revision as of 20:58, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1wzc.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate==
		+	<StructureSection load='1wzc' size='340' side='right' caption='[[1wzc]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WZC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PH0926 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_phosphatase Mannosyl-3-phosphoglycerate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.70 3.1.3.70] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wzc RCSB], [http://www.ebi.ac.uk/pdbsum/1wzc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wzc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mannosyl-3-phosphoglycerate phosphatase (MPGP) catalyzes the dephosphorylation of alpha-mannosyl-3-phosphoglycerate (MPG) to produce alpha-mannosylglycerate (MG). In the hyperthermophile Pyrococcus horikoshii, MPGP plays a role in a series of enzyme reactions that are involved in the MG-biosynthesis pathway, which is important for maintaining life under conditions of high salt concentration. Crystal structures of P. horikoshii MPGP (PhoMPGP) in the holo form and in the apo form lacking the magnesium ion were determined by the multiple-wavelength anomalous diffraction method using SeMet-substituted PhoMPGP. PhoMPGP consists of two domains: a core domain that is conserved in the haloacid dehalogenase superfamily and a cap domain that is specific to the C2B cap subclass of the superfamily. Apo-form crystals contain two PhoMPGP molecules: one in the open conformation and the other in the closed conformation. In holo-form crystals both of the two molecules are in the closed conformation with phosphate and magnesium ions. PhoMPGP has a specific hairpin loop that is bent towards the active site in the closed conformation of both the apo and holo forms. PhoMPGP has a cavity between the two domains which is considered to be the substrate-binding site as a phosphate ion is located in the cavity, mimicking the binding manner of the phosphate group of MPG. The cavity is sequestered in the closed conformation such that a conformational change is indispensable for the release of products. A salt bridge from the general acid/base Asp10 to Arg170 is observed in the holo-form PhoMPGP which is not present in the open form. The importance of the conformational change in the activity of PhoMPGP is discussed.

-	~~{{STRUCTURE_1wzc\| PDB=1wzc \| SCENE= }}~~	+	Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii.,Kawamura T, Watanabe N, Tanaka I Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1267-76. Epub 2008, Nov 18. PMID:19018103<ref>PMID:19018103</ref>

-	~~===Crystal structure~~ of ~~Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19018103}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1wzc]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019018103<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]

OCA: Protected "1wzc" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:56:16 GMT

Protected "1wzc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:56, 5 January 2013

OCA at 11:56, 5 January 2013

OCA — Sat, 05 Jan 2013 11:56:11 GMT

←Older revision		Revision as of 11:56, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1wzc.png\|left\|200px]]		[[Image:1wzc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1wzc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1wzc\| PDB=1wzc \| SCENE= }}		{{STRUCTURE_1wzc\| PDB=1wzc \| SCENE= }}

	===Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate===		===Crystal structure of Pyrococcus horikoshii mannosyl-3-phosphoglycerate phosphatase complexed with MG2+ and phosphate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19018103}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19018103 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19018103}}		{{ABSTRACT_PUBMED_19018103}}

	==About this Structure==		==About this Structure==
-	~~1WZC~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA].	+	[[1wzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19018103~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019018103</ref><references group="xtra"/>
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
Line 30:		Line 18:
	[[Category: Watanabe, N.]]		[[Category: Watanabe, N.]]
	[[Category: Haloacid dehalogenase like hydrolase]]		[[Category: Haloacid dehalogenase like hydrolase]]
		+	[[Category: Hydrolase]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:59:15 2009''

OCA at 15:59, 17 February 2009

OCA — Tue, 17 Feb 2009 15:59:16 GMT

←Older revision		Revision as of 15:59, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1WZC is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA].	+	1WZC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZC OCA].

	==Reference==		==Reference==
-	~~Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii., Kawamura T, Watanabe N, Tanaka I, Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1267-76. Epub 2008, Nov 18.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19018103 19018103]~~	+	<ref group="xtra">PMID:19018103</ref><references group="xtra"/>
	[[Category: Mannosyl-3-phosphoglycerate phosphatase]]		[[Category: Mannosyl-3-phosphoglycerate phosphatase]]
	[[Category: Pyrococcus horikoshii]]		[[Category: Pyrococcus horikoshii]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Kawamura, T.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Tanaka, I.]]
		+	[[Category: Watanabe, N.]]
	[[Category: Haloacid dehalogenase like hydrolase]]		[[Category: Haloacid dehalogenase like hydrolase]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 28 20~~:28:29 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:59:15 2009''