1x4q - Revision history

OCA at 13:58, 9 May 2024

OCA — Thu, 09 May 2024 13:58:52 GMT

←Older revision		Revision as of 13:58, 9 May 2024
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	==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==		==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==
-	<StructureSection load='1x4q' size='340' side='right'caption='[[1x4q~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1x4q' size='340' side='right'caption='[[1x4q]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PRPF3, HPRP3, PRP3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [https://pdbe.org/1x4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [https://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [https://pdbe.org/1x4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [https://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[https://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>	+	[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[https://omim.org/entry/601414 601414]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.	+	[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: He, F]]	+	[[Category: He F]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Muto, Y]]	+	[[Category: Muto Y]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shirouzu M]]
-	[[Category: Shirouzu, M]]	+	[[Category: Terada T]]
-	[[Category: Terada, T]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Pwi domain]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rsgi~~]]	+

OCA at 07:04, 2 March 2022

OCA — Wed, 02 Mar 2022 07:04:24 GMT

←Older revision		Revision as of 07:04, 2 March 2022
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	<StructureSection load='1x4q' size='340' side='right'caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1x4q' size='340' side='right'caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [~~http~~://pdbe.org/1x4q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [https://pdbe.org/1x4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [https://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[~~http~~://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>	+	[[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[https://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.	+	[[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:38, 6 January 2021

OCA — Wed, 06 Jan 2021 09:38:01 GMT

←Older revision		Revision as of 09:38, 6 January 2021
Line 1:		Line 1:

	==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==		==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==
-	<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1x4q' size='340' side='right'caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://pdbe.org/1x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://pdbe.org/1x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Nucleoprotein\|Nucleoprotein]]	+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
-	*[[Pre-mRNA-splicing ~~factor~~\|Pre-mRNA-splicing ~~factor~~]]	+	*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 16:40, 11 April 2018

OCA — Wed, 11 Apr 2018 16:40:50 GMT

←Older revision		Revision as of 16:40, 11 April 2018
Line 1:		Line 1:
		+
	==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==		==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==
	<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://pdbe.org/1x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://pdbe.org/1x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:18, 9 February 2016

OCA — Tue, 09 Feb 2016 12:18:58 GMT

←Older revision		Revision as of 12:18, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x4q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 22:11, 10 September 2015

OCA — Thu, 10 Sep 2015 22:11:19 GMT

←Older revision		Revision as of 22:11, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://pdbe.org/1x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: He, F]]		[[Category: He, F]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 14:03, 6 January 2015

OCA — Tue, 06 Jan 2015 14:03:01 GMT

←Older revision		Revision as of 14:03, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>		[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: He, F.]]	+	[[Category: He, F]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Muto, Y.]]	+	[[Category: Muto, Y]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shirouzu, M.]]	+	[[Category: Shirouzu, M]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: Pwi domain]]		[[Category: Pwi domain]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]

OCA at 22:04, 29 September 2014

OCA — Mon, 29 Sep 2014 22:04:43 GMT

←Older revision		Revision as of 22:04, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1x4q\| PDB=1x4q \| SCENE= }}~~	+	==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==
-	===Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)===	+	<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref><ref>PMID:12714658</ref><ref>PMID:17932117</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
-	==Function==	+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.		[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[~~1x4q~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~1X4Q OCA~~].	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]		*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, F.]]		[[Category: He, F.]]

OCA at 07:18, 25 March 2013

OCA — Mon, 25 Mar 2013 07:18:26 GMT

←Older revision		Revision as of 07:18, 25 March 2013
Line 1:		Line 1:
-	[[Image:1x4q.png\|left\|200px]]
-
	{{STRUCTURE_1x4q\| PDB=1x4q \| SCENE= }}		{{STRUCTURE_1x4q\| PDB=1x4q \| SCENE= }}
-
	===Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)===		===Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref><ref>PMID:12714658</ref><ref>PMID:17932117</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.

	==About this Structure==		==About this Structure==
Line 12:		Line 14:
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]		*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, F.]]		[[Category: He, F.]]

OCA at 13:48, 20 October 2012

OCA — Sat, 20 Oct 2012 13:48:56 GMT

←Older revision		Revision as of 13:48, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[1x4q]] is a 1 chain structure ~~of [[Nucleoprotein]] and [[Pre-mRNA-splicing factor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA].	+	[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA].

	==See Also==		==See Also==