1x5q - Revision history

OCA at 14:00, 9 May 2024

OCA — Thu, 09 May 2024 14:00:50 GMT

←Older revision		Revision as of 14:00, 9 May 2024
Line 1:		Line 1:

	==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==		==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==
-	<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [https://pdbe.org/1x5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [https://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [https://pdbe.org/1x5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [https://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>	+	[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hayashi, F]]	+	[[Category: Hayashi F]]
-	[[Category: Nagashima, T]]	+	[[Category: Nagashima T]]
-	[[Category: Qin~~, X R]]~~	+	[[Category: Qin XR]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Hscrib]]~~	+
-	~~[[Category: Lap4 protein]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Scribble homolog protein~~]]	+

OCA at 07:05, 2 March 2022

OCA — Wed, 02 Mar 2022 07:05:58 GMT

←Older revision		Revision as of 07:05, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [~~http~~://pdbe.org/1x5q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [https://pdbe.org/1x5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [https://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>	+	[[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:41, 6 January 2021

OCA — Wed, 06 Jan 2021 09:41:39 GMT

←Older revision		Revision as of 09:41, 6 January 2021
Line 1:		Line 1:

	==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==		==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==
-	<StructureSection load='1x5q' size='340' side='right' caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://pdbe.org/1x5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://pdbe.org/1x5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Nagashima, T]]		[[Category: Nagashima, T]]

OCA at 16:23, 11 April 2018

OCA — Wed, 11 Apr 2018 16:23:57 GMT

←Older revision		Revision as of 16:23, 11 April 2018
Line 1:		Line 1:
		+
	==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==		==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==
	<StructureSection load='1x5q' size='340' side='right' caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1x5q' size='340' side='right' caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://pdbe.org/1x5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://pdbe.org/1x5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x5q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 07:51, 11 September 2015

OCA — Fri, 11 Sep 2015 07:51:29 GMT

←Older revision		Revision as of 07:51, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1x5q' size='340' side='right' caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1x5q' size='340' side='right' caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://pdbe.org/1x5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/~~LAP4_HUMAN LAP4_HUMAN~~]] ~~Defects~~ in ~~SCRIB are a cause of neural tube defects (NTD) [MIM:[http://omim.org/~~entry/182940 182940]]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.~~<ref>PMID:22095531</ref>~~	+	[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~LAP4_HUMAN LAP4_HUMAN~~]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:~~19041750~~</ref> <ref>PMID:18716323</ref> <ref>PMID:~~18641685~~</ref>	+	[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Nagashima, T]]		[[Category: Nagashima, T]]

OCA at 12:49, 6 January 2015

OCA — Tue, 06 Jan 2015 12:49:20 GMT

←Older revision		Revision as of 12:49, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Defects in SCRIB are a cause of neural tube defects (NTD) [MIM:[http://omim.org/entry/182940 182940]]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.<ref>PMID:22095531</ref>		[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Defects in SCRIB are a cause of neural tube defects (NTD) [MIM:[http://omim.org/entry/182940 182940]]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.<ref>PMID:22095531</ref>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hayashi, F.]]	+	[[Category: Hayashi, F]]
-	[[Category: Nagashima, T.]]	+	[[Category: Nagashima, T]]
-	[[Category: Qin, X R.]]	+	[[Category: Qin, X R]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
Line 37:		Line 37:
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Scribble homolog protein]]		[[Category: Scribble homolog protein]]
-	[[Category: Structural genomic]]

OCA at 20:33, 29 September 2014

OCA — Mon, 29 Sep 2014 20:33:55 GMT

←Older revision		Revision as of 20:33, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1x5q\| PDB=1x5q \| SCENE= }}~~	+	==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==
-	===Solution structure of the first PDZ domain of scribble homolog protein (hScrib)===	+	<StructureSection load='1x5q' size='340' side='right' caption='[[1x5q]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Defects in SCRIB are a cause of neural tube defects (NTD) [MIM:[http://omim.org/entry/182940 182940]]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.<ref>PMID:22095531</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
-	==Function==	+	<table>
-	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref><ref>PMID:15775968</ref><ref>PMID:16344308</ref><ref>PMID:16965391</ref><ref>PMID:19041750</ref><ref>PMID:18716323</ref><ref>PMID:18641685</ref>	+	== Disease ==
-		+	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Defects in SCRIB are a cause of neural tube defects (NTD) [MIM:[http://omim.org/entry/182940 182940]]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.<ref>PMID:22095531</ref>
-	==~~About this Structure~~==	+	== Function ==
-	[[~~1x5q~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~1X5Q OCA~~].	+	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:19041750</ref> <ref>PMID:18716323</ref> <ref>PMID:18641685</ref>
-		+	== Evolutionary Conservation ==
-	==~~Reference~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	<references ~~group="xtra"~~/><~~references~~/>	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 03:45, 25 March 2013

OCA — Mon, 25 Mar 2013 03:45:06 GMT

←Older revision		Revision as of 03:45, 25 March 2013
Line 1:		Line 1:
-	[[Image:1x5q.png\|left\|200px]]
-
	{{STRUCTURE_1x5q\| PDB=1x5q \| SCENE= }}		{{STRUCTURE_1x5q\| PDB=1x5q \| SCENE= }}
-
	===Solution structure of the first PDZ domain of scribble homolog protein (hScrib)===		===Solution structure of the first PDZ domain of scribble homolog protein (hScrib)===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Defects in SCRIB are a cause of neural tube defects (NTD) [MIM:[http://omim.org/entry/182940 182940]]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.<ref>PMID:22095531</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/LAP4_HUMAN LAP4_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref><ref>PMID:15775968</ref><ref>PMID:16344308</ref><ref>PMID:16965391</ref><ref>PMID:19041750</ref><ref>PMID:18716323</ref><ref>PMID:18641685</ref>

	==About this Structure==		==About this Structure==
	[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA].		[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA: Protected "1x5q" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:18:14 GMT

Protected "1x5q" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:18, 5 January 2013

OCA at 11:18, 5 January 2013

OCA — Sat, 05 Jan 2013 11:18:11 GMT

←Older revision		Revision as of 11:18, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1x5q.png\|left\|200px]]		[[Image:1x5q.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1x5q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1x5q\| PDB=1x5q \| SCENE= }}		{{STRUCTURE_1x5q\| PDB=1x5q \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~1X5Q~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA].	+	[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
Line 32:		Line 25:
	[[Category: Scribble homolog protein]]		[[Category: Scribble homolog protein]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:34:24 2009''