1xah - Revision history

OCA at 06:43, 23 August 2023

OCA — Wed, 23 Aug 2023 06:43:21 GMT

←Older revision		Revision as of 06:43, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1xah' size='340' side='right'caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1xah' size='340' side='right'caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAD:NICOTINAMIDE~~-~~ADENINE-DINUCLEOTIDE'>NAD</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; max-height: 3em;'>[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1280~~ "~~Micrococcus aureus~~" ~~(Rosenbach 1884) Zopf 1885])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [https://pdbe.org/1xah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [https://www.ebi.ac.uk/pdbsum/1xah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xah ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [~~http~~://pdbe.org/1xah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xah ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AROB_STAAR AROB_STAAR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3-dehydroquinate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Charles, I]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Dhaliwal, B]]	+	[[Category: Charles I]]
-	[[Category: Hawkins~~, A R~~]]	+	[[Category: Dhaliwal B]]
-	[[Category: Leslie, K]]	+	[[Category: Hawkins AR]]
-	[[Category: Lockyer, M]]	+	[[Category: Leslie K]]
-	[[Category: Nichols~~, C E~~]]	+	[[Category: Lockyer M]]
-	[[Category: Ren, J]]	+	[[Category: Nichols CE]]
-	[[Category: Stammers~~, D K]]~~	+	[[Category: Ren J]]
-	~~[[Category: Aromatic amino acid biosynthesis]]~~	+	[[Category: Stammers DK]]
-	~~[[Category: Cyclase]]~~	+
-	~~[[Category: Dhq]]~~	+
-	~~[[Category: Domain movement]]~~	+
-	~~[[Category: Form b]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Open form]]~~	+
-	~~[[Category: Sadhq]]~~	+
-	~~[[Category: Shikimate pathway~~]]	+

OCA at 09:50, 6 January 2021

OCA — Wed, 06 Jan 2021 09:50:30 GMT

←Older revision		Revision as of 09:50, 6 January 2021
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	==CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+==		==CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+==
-	<StructureSection load='1xah' size='340' side='right' caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1xah' size='340' side='right'caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://pdbe.org/1xah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://pdbe.org/1xah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xah ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: 3-dehydroquinate synthase]]		[[Category: 3-dehydroquinate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Charles, I]]		[[Category: Charles, I]]
	[[Category: Dhaliwal, B]]		[[Category: Dhaliwal, B]]

OCA at 07:16, 18 April 2018

OCA — Wed, 18 Apr 2018 07:16:10 GMT

←Older revision		Revision as of 07:16, 18 April 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+==		==CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+==
	<StructureSection load='1xah' size='340' side='right' caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1xah' size='340' side='right' caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://pdbe.org/1xah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://pdbe.org/1xah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xah ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xah_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xah_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:54, 7 February 2016

OCA — Sun, 07 Feb 2016 06:54:41 GMT

←Older revision		Revision as of 06:54, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xah ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:55, 9 September 2015

OCA — Wed, 09 Sep 2015 22:55:01 GMT

←Older revision		Revision as of 22:55, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1xah' size='340' side='right' caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1xah' size='340' side='right' caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://pdbe.org/1xah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xah" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: 3-dehydroquinate synthase]]		[[Category: 3-dehydroquinate synthase]]
-	[[Category: Staphylococcus aureus]]
	[[Category: Charles, I]]		[[Category: Charles, I]]
	[[Category: Dhaliwal, B]]		[[Category: Dhaliwal, B]]

OCA at 12:43, 6 January 2015

OCA — Tue, 06 Jan 2015 12:43:50 GMT

←Older revision		Revision as of 12:43, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: 3-dehydroquinate synthase]]		[[Category: 3-dehydroquinate synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Charles, I.]]	+	[[Category: Charles, I]]
-	[[Category: Dhaliwal, B.]]	+	[[Category: Dhaliwal, B]]
-	[[Category: Hawkins, A R.]]	+	[[Category: Hawkins, A R]]
-	[[Category: Leslie, K.]]	+	[[Category: Leslie, K]]
-	[[Category: Lockyer, M.]]	+	[[Category: Lockyer, M]]
-	[[Category: Nichols, C E.]]	+	[[Category: Nichols, C E]]
-	[[Category: Ren, J.]]	+	[[Category: Ren, J]]
-	[[Category: Stammers, D K.]]	+	[[Category: Stammers, D K]]
	[[Category: Aromatic amino acid biosynthesis]]		[[Category: Aromatic amino acid biosynthesis]]
	[[Category: Cyclase]]		[[Category: Cyclase]]

OCA at 19:32, 29 September 2014

OCA — Mon, 29 Sep 2014 19:32:18 GMT

←Older revision		Revision as of 19:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xah.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+==
		+	<StructureSection load='1xah' size='340' side='right' caption='[[1xah]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr5\|1nr5]], [[1nrx\|1nrx]], [[1nve\|1nve]], [[1nvd\|1nvd]], [[1nvb\|1nvb]], [[1nua\|1nua]], [[1nva\|1nva]], [[1nvf\|1nvf]], [[1xag\|1xag]], [[1xai\|1xai]], [[1xaj\|1xaj]], [[1xal\|1xal]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_synthase 3-dehydroquinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.4 4.2.3.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xah RCSB], [http://www.ebi.ac.uk/pdbsum/1xah PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xah_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dehydroquinate synthase (DHQS) is a potential target for the development of novel broad-spectrum antimicrobial drugs, active against both prokaryotes and lower eukaryotes. Structures have been reported for Aspergillus nidulans DHQS (AnDHQS) in complexes with a range of ligands. Analysis of these AnDHQS structures showed that a large-scale domain movement occurs during the normal catalytic cycle, with a complex series of structural elements propagating substrate binding-induced conformational changes away from the active site to distal locations. Compared to corresponding fungal enzymes, DHQS from bacterial species are both mono-functional and significantly smaller. We have therefore determined the structure of Staphylococcus aureus DHQS (SaDHQS) in five liganded states, allowing comparison of ligand-induced conformational changes and mechanisms of domain closure between fungal and bacterial enzymes. This comparative analysis shows that substrate binding initiates a large-scale domain closure in both species' DHQS and that the active site stereochemistry, of the catalytically competent closed-form enzyme thus produced, is also highly conserved. However, comparison of AnDHQS and SaDHQS open-form structures, and analysis of the putative dynamic processes by which the transition to the closed-form states are made, shows a far lower degree of similarity, indicating a significant structural divergence. As a result, both the nature of the propagation of conformational change and the mechanical systems involved in this propagation are quite different between the DHQSs from the two species.

-	~~{{STRUCTURE_1xah\| PDB=1xah \| SCENE= }}~~	+	Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.,Nichols CE, Ren J, Leslie K, Dhaliwal B, Lockyer M, Charles I, Hawkins AR, Stammers DK J Mol Biol. 2004 Oct 22;343(3):533-46. PMID:15465043<ref>PMID:15465043</ref>

-	~~===CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15465043}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xah]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015465043<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 3-dehydroquinate synthase]]		[[Category: 3-dehydroquinate synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA: Protected "1xah" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:42:13 GMT

Protected "1xah" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 5 January 2013

OCA at 12:42, 5 January 2013

OCA — Sat, 05 Jan 2013 12:42:08 GMT

←Older revision		Revision as of 12:42, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xah.png\|left\|200px]]		[[Image:1xah.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xah", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xah\| PDB=1xah \| SCENE= }}		{{STRUCTURE_1xah\| PDB=1xah \| SCENE= }}

	===CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+===		===CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15465043}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15465043 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15465043}}		{{ABSTRACT_PUBMED_15465043}}

	==About this Structure==		==About this Structure==
-	~~1XAH~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA].	+	[[1xah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15465043~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015465043</ref><references group="xtra"/>
	[[Category: 3-dehydroquinate synthase]]		[[Category: 3-dehydroquinate synthase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
Line 43:		Line 31:
	[[Category: Sadhq]]		[[Category: Sadhq]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:05:43 2009''

OCA at 10:05, 16 February 2009

OCA — Mon, 16 Feb 2009 10:05:44 GMT

←Older revision		Revision as of 10:05, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1XAH is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA].	+	1XAH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAH OCA].

	==Reference==		==Reference==
-	Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases., Nichols CE, Ren J, Leslie K, Dhaliwal B, Lockyer M, Charles I, Hawkins AR, Stammers DK, J Mol Biol. 2004 Oct 22;343(3):533-46. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15465043 15465043]~~	+	<ref group="xtra">PMID:15465043</ref><references group="xtra"/>
	[[Category: 3-dehydroquinate synthase]]		[[Category: 3-dehydroquinate synthase]]
-	[[Category: Single protein]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Charles, I.]]		[[Category: Charles, I.]]
Line 45:		Line 44:
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 14~~:15:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:05:43 2009''