1xb1 - Revision history

OCA at 14:04, 9 May 2024

OCA — Thu, 09 May 2024 14:04:21 GMT

←Older revision		Revision as of 14:04, 9 May 2024
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	<StructureSection load='1xb1' size='340' side='right'caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1xb1' size='340' side='right'caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1xb0\|1xb0]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [https://pdbe.org/1xb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [~~http~~://pdbe.org/1xb1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xb1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb1 ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Defects in DIABLO are the cause of deafness autosomal dominant type 64 (DFNA64) [MIM:[http://omim.org/entry/614152 614152]]. DFNA64 is a form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:21722859</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BIRC8_HUMAN BIRC8_HUMAN]] Protects against apoptosis mediated by BAX. [[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.<ref>PMID:10929711</ref> <ref>PMID:14523016</ref> <ref>PMID:15200957</ref>	+	[https://www.uniprot.org/uniprot/BIRC8_HUMAN BIRC8_HUMAN] Protects against apoptosis mediated by BAX.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1xb1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1xb1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Baculoviral IAP repeat-containing protein 3D structures\|Baculoviral IAP repeat-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eckelman~~, B P~~]]	+	[[Category: Eckelman BP]]
-	[[Category: Nunes~~, V A~~]]	+	[[Category: Nunes VA]]
-	[[Category: Renatus, M]]	+	[[Category: Renatus M]]
-	[[Category: Salvesen~~, G S~~]]	+	[[Category: Salvesen GS]]
-	[[Category: Sampaio~~, C A.M~~]]	+	[[Category: Sampaio CAM]]
-	[[Category: Shin, H]]	+	[[Category: Shin H]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Caspase inhibition]]~~	+
-	~~[[Category: Diabolo]]~~	+
-	~~[[Category: Iap]]~~	+
-	~~[[Category: Smac~~]]	+

OCA at 09:51, 6 January 2021

OCA — Wed, 06 Jan 2021 09:51:12 GMT

←Older revision		Revision as of 09:51, 6 January 2021
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	==The Structure of the BIR domain of IAP-like protein 2==		==The Structure of the BIR domain of IAP-like protein 2==
-	<StructureSection load='1xb1' size='340' side='right' caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1xb1' size='340' side='right'caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xb0\|1xb0]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://pdbe.org/1xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://pdbe.org/1xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Baculoviral IAP repeat-containing protein\|Baculoviral IAP repeat-containing protein]]	+	*[[Baculoviral IAP repeat-containing protein 3D structures\|Baculoviral IAP repeat-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Eckelman, B P]]		[[Category: Eckelman, B P]]
	[[Category: Nunes, V A]]		[[Category: Nunes, V A]]

OCA at 06:57, 18 April 2018

OCA — Wed, 18 Apr 2018 06:57:12 GMT

←Older revision		Revision as of 06:57, 18 April 2018
Line 1:		Line 1:
		+
	==The Structure of the BIR domain of IAP-like protein 2==		==The Structure of the BIR domain of IAP-like protein 2==
	<StructureSection load='1xb1' size='340' side='right' caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1xb1' size='340' side='right' caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://pdbe.org/1xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://pdbe.org/1xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xb1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xb1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:28, 8 February 2016

OCA — Mon, 08 Feb 2016 12:28:34 GMT

←Older revision		Revision as of 12:28, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xb1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:34, 10 September 2015

OCA — Thu, 10 Sep 2015 11:34:47 GMT

←Older revision		Revision as of 11:34, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xb1' size='340' side='right' caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1xb1' size='340' side='right' caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://pdbe.org/1xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xb1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Baculoviral IAP repeat-containing protein\|Baculoviral IAP repeat-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Eckelman, B P]]		[[Category: Eckelman, B P]]
	[[Category: Nunes, V A]]		[[Category: Nunes, V A]]

OCA at 12:16, 6 January 2015

OCA — Tue, 06 Jan 2015 12:16:49 GMT

←Older revision		Revision as of 12:16, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Defects in DIABLO are the cause of deafness autosomal dominant type 64 (DFNA64) [MIM:[http://omim.org/entry/614152 614152]]. DFNA64 is a form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:21722859</ref>		[[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Defects in DIABLO are the cause of deafness autosomal dominant type 64 (DFNA64) [MIM:[http://omim.org/entry/614152 614152]]. DFNA64 is a form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:21722859</ref>
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Eckelman, B P.]]	+	[[Category: Eckelman, B P]]
-	[[Category: Nunes, V A.]]	+	[[Category: Nunes, V A]]
-	[[Category: Renatus, M.]]	+	[[Category: Renatus, M]]
-	[[Category: Salvesen, G S.]]	+	[[Category: Salvesen, G S]]
-	[[Category: Sampaio, C A.M.]]	+	[[Category: Sampaio, C A.M]]
-	[[Category: Shin, H.]]	+	[[Category: Shin, H]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Caspase inhibition]]		[[Category: Caspase inhibition]]

OCA at 19:22, 29 September 2014

OCA — Mon, 29 Sep 2014 19:22:07 GMT

←Older revision		Revision as of 19:22, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1xb1~~\| ~~PDB~~=1xb1 \| ~~SCENE~~= }}	+	==The Structure of the BIR domain of IAP-like protein 2==
-	===~~The Structure~~ of the ~~BIR domain~~ of IAP-~~like~~ protein 2===	+	<StructureSection load='1xb1' size='340' side='right' caption='[[1xb1]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15485395}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XB1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xb0\|1xb0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIRC8, ILP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1xb1 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Defects in DIABLO are the cause of deafness autosomal dominant type 64 (DFNA64) [MIM:[http://omim.org/entry/614152 614152]]. DFNA64 is a form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:21722859</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BIRC8_HUMAN BIRC8_HUMAN]] Protects against apoptosis mediated by BAX. [[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.<ref>PMID:10929711</ref> <ref>PMID:14523016</ref> <ref>PMID:15200957</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xb1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several IAP (inhibitor of apoptosis) proteins regulate cell fate decisions, and the X-linked IAP (XIAP) does so in part by inhibiting caspases, proteases that execute the apoptotic pathway. A tissue-specific homologue of XIAP, known as ILP2 (IAP-like protein 2), has previously been implicated in the control of apoptosis in the testis by direct inhibition of caspase 9. In examining this protein we found that the putative caspase 9 interaction domain is a surprisingly weak inhibitor and is also conformationally unstable. Comparison with the equivalent domain in XIAP demonstrated that the instability is due to the lack of a linker segment N-terminal to the inhibitory BIR (baculovirus IAP repeat) domain. Fusion of a 9-residue linker from XIAP to the N-terminus of ILP2 restored tight caspase 9 inhibition, dramatically increased conformational stability and allowed crystallization of the ILP2 BIR domain in a form strikingly similar to the XIAP third BIR domain. We conclude that ILP2 is an unstable protein, and cannot inhibit caspase 9 in a physiological way on its own. We speculate that ILP2 requires assistance from unidentified cellular factors to be an effective inhibitor of apoptosis in vivo.

-	~~==Disease==~~	+	The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.,Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS Biochem J. 2005 Jan 1;385(Pt 1):1-10. PMID:15485395<ref>PMID:15485395</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Defects in DIABLO are the cause of deafness autosomal dominant type 64~~ (~~DFNA64~~) ~~[MIM~~:~~[http://omim.org/entry/614152 614152]]. DFNA64 is a form of non~~-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:~~21722859~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/BIRC8_HUMAN BIRC8_HUMAN]] Protects against apoptosis mediated by BAX. [[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Promotes apoptosis by activating caspases in~~ the ~~cytochrome c/Apaf-1/caspase-9 pathway~~. ~~Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP)~~. ~~Inhibits the activity~~ of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.<~~ref~~>~~PMID:10929711~~</~~ref~~>~~<ref>PMID:14523016</ref><ref>PMID:15200957</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:015485395</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eckelman, B P.]]		[[Category: Eckelman, B P.]]

OCA at 12:01, 24 March 2013

OCA — Sun, 24 Mar 2013 12:01:26 GMT

←Older revision		Revision as of 12:01, 24 March 2013
Line 1:		Line 1:
-	[[Image:1xb1.png\|left\|200px]]
-
	{{STRUCTURE_1xb1\| PDB=1xb1 \| SCENE= }}		{{STRUCTURE_1xb1\| PDB=1xb1 \| SCENE= }}
-
	===The Structure of the BIR domain of IAP-like protein 2===		===The Structure of the BIR domain of IAP-like protein 2===
		+	{{ABSTRACT_PUBMED_15485395}}

-	~~{{ABSTRACT_PUBMED_15485395}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Defects in DIABLO are the cause of deafness autosomal dominant type 64 (DFNA64) [MIM:[http://omim.org/entry/614152 614152]]. DFNA64 is a form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:21722859</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BIRC8_HUMAN BIRC8_HUMAN]] Protects against apoptosis mediated by BAX. [[http://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN]] Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.<ref>PMID:10929711</ref><ref>PMID:14523016</ref><ref>PMID:15200957</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015485395</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015485395</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eckelman, B P.]]		[[Category: Eckelman, B P.]]

OCA: Protected "1xb1" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:23:00 GMT

Protected "1xb1" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:23, 5 January 2013

OCA at 12:22, 5 January 2013

OCA — Sat, 05 Jan 2013 12:22:58 GMT

←Older revision		Revision as of 12:22, 5 January 2013
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-	{{Seed}}
	[[Image:1xb1.png\|left\|200px]]		[[Image:1xb1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xb1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1xb1\| PDB=1xb1 \| SCENE= }}		{{STRUCTURE_1xb1\| PDB=1xb1 \| SCENE= }}

	===The Structure of the BIR domain of IAP-like protein 2===		===The Structure of the BIR domain of IAP-like protein 2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15485395}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15485395 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15485395}}		{{ABSTRACT_PUBMED_15485395}}

	==About this Structure==		==About this Structure==
-	~~1XB1~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA].	+	[[1xb1]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XB1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15485395~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015485395</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eckelman, B P.]]		[[Category: Eckelman, B P.]]
Line 36:		Line 24:
	[[Category: Iap]]		[[Category: Iap]]
	[[Category: Smac]]		[[Category: Smac]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:00:29 2009''