1xew - Revision history

OCA at 13:36, 13 March 2024

OCA — Wed, 13 Mar 2024 13:36:32 GMT

←Older revision		Revision as of 13:36, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='1xew' size='340' side='right'caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xew' size='340' side='right'caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43587 Atcc 43587~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1xex\|1xex]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2261 ATCC 43587])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [https://pdbe.org/1xew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [https://www.ebi.ac.uk/pdbsum/1xew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xew ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [~~http~~://pdbe.org/1xew PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xew PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xew ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SMC_PYRFU SMC_PYRFU] Required for chromosome condensation and partitioning (By similarity). Binds single-stranded but not double-stranded DNA.[HAMAP-Rule:MF_01894]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xew ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xew ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Structural maintenance of chromosome (SMC) proteins play a central role in higher-order chromosome structure in all kingdoms of life. SMC proteins consist of a long coiled-coil domain that joins an ATP binding cassette (ABC) ATPase domain on one side and a dimerization domain on the other side. SMC proteins require ATP binding or hydrolysis to promote cohesion and condensation, which is suggested to proceed via formation of SMC rings or assemblies. To learn more about the role of ATP in the architecture of SMC proteins, we report crystal structures of nucleotide-free and ATP bound P. furiosus SMC ATPase domains. ATP dimerizes two SMC ATPase domains by binding to opposing Walker A and signature motifs, indicating that ATP binding can directly assemble SMC proteins. DNA stimulates ATP hydrolysis in the engaged SMC ABC domains, suggesting that ATP hydrolysis can be allosterically regulated. Structural and mutagenesis data identify an SMC protein conserved-arginine finger that is required for DNA stimulation of the ATPase activity and directly connects a putative DNA interaction site to ATP. Our results suggest that stimulation of the SMC ATPase activity may be a specific feature to regulate the ATP-driven assembly and disassembly of SMC proteins.
-
-	Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases.,Lammens A, Schele A, Hopfner KP Curr Biol. 2004 Oct 5;14(19):1778-82. PMID:15458651<ref>PMID:15458651</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1xew" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Condensin\|Condensin]]		*[[Condensin\|Condensin]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43587]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hopfner, K P~~]]	+	[[Category: Pyrococcus furiosus]]
-	[[Category: ~~Lammens, A~~]]	+	[[Category: Hopfner K-P]]
-	[[Category: ~~Schele,~~ A]]	+	[[Category: Lammens A]]
-	[[Category: ~~Abc-atpase]]~~	+	[[Category: Schele A]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cohesin]]~~	+
-	~~[[Category: Condensin]]~~	+
-	~~[[Category: Smc]]~~	+
-	~~[[Category: Structural maintenance of chromosome~~]]	+

OCA at 09:56, 6 January 2021

OCA — Wed, 06 Jan 2021 09:56:12 GMT

←Older revision		Revision as of 09:56, 6 January 2021
Line 1:		Line 1:

	==Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.==		==Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.==
-	<StructureSection load='1xew' size='340' side='right' caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1xew' size='340' side='right'caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XEW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xex\|1xex]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://pdbe.org/1xew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xew ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://pdbe.org/1xew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xew_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xew_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1xew" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1xew" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Condensin\|Condensin]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43587]]		[[Category: Atcc 43587]]
		+	[[Category: Large Structures]]
	[[Category: Hopfner, K P]]		[[Category: Hopfner, K P]]
	[[Category: Lammens, A]]		[[Category: Lammens, A]]

OCA at 08:06, 12 October 2017

OCA — Thu, 12 Oct 2017 08:06:09 GMT

←Older revision		Revision as of 08:06, 12 October 2017
Line 1:		Line 1:
		+
	==Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.==		==Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.==
	<StructureSection load='1xew' size='340' side='right' caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xew' size='340' side='right' caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://pdbe.org/1xew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://pdbe.org/1xew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:11, 7 February 2016

OCA — Sun, 07 Feb 2016 18:11:20 GMT

←Older revision		Revision as of 18:11, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xew ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:55, 10 September 2015

OCA — Thu, 10 Sep 2015 03:55:44 GMT

←Older revision		Revision as of 03:55, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xew' size='340' side='right' caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xew' size='340' side='right' caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_furiosus Pyrococcus furiosus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XEW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ~~Pyrococcus furiosus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://pdbe.org/1xew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xew" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pyrococcus furiosus~~]]	+	[[Category: Atcc 43587]]
	[[Category: Hopfner, K P]]		[[Category: Hopfner, K P]]
	[[Category: Lammens, A]]		[[Category: Lammens, A]]

OCA at 12:23, 6 January 2015

OCA — Tue, 06 Jan 2015 12:23:46 GMT

←Older revision		Revision as of 12:23, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XEW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
-	[[Category: Hopfner, K P.]]	+	[[Category: Hopfner, K P]]
-	[[Category: Lammens, A.]]	+	[[Category: Lammens, A]]
-	[[Category: Schele, A.]]	+	[[Category: Schele, A]]
	[[Category: Abc-atpase]]		[[Category: Abc-atpase]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 18:24, 29 September 2014

OCA — Mon, 29 Sep 2014 18:24:16 GMT

←Older revision		Revision as of 18:24, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xew.~~png~~\|~~left~~\|200px]]	+	==Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.==
		+	<StructureSection load='1xew' size='340' side='right' caption='[[1xew]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XEW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xex\|1xex]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xew RCSB], [http://www.ebi.ac.uk/pdbsum/1xew PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xew_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structural maintenance of chromosome (SMC) proteins play a central role in higher-order chromosome structure in all kingdoms of life. SMC proteins consist of a long coiled-coil domain that joins an ATP binding cassette (ABC) ATPase domain on one side and a dimerization domain on the other side. SMC proteins require ATP binding or hydrolysis to promote cohesion and condensation, which is suggested to proceed via formation of SMC rings or assemblies. To learn more about the role of ATP in the architecture of SMC proteins, we report crystal structures of nucleotide-free and ATP bound P. furiosus SMC ATPase domains. ATP dimerizes two SMC ATPase domains by binding to opposing Walker A and signature motifs, indicating that ATP binding can directly assemble SMC proteins. DNA stimulates ATP hydrolysis in the engaged SMC ABC domains, suggesting that ATP hydrolysis can be allosterically regulated. Structural and mutagenesis data identify an SMC protein conserved-arginine finger that is required for DNA stimulation of the ATPase activity and directly connects a putative DNA interaction site to ATP. Our results suggest that stimulation of the SMC ATPase activity may be a specific feature to regulate the ATP-driven assembly and disassembly of SMC proteins.

-	~~{{STRUCTURE_1xew\| PDB=1xew \| SCENE= }}~~	+	Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases.,Lammens A, Schele A, Hopfner KP Curr Biol. 2004 Oct 5;14(19):1778-82. PMID:15458651<ref>PMID:15458651</ref>

-	~~===Structural biochemistry~~ of ~~ATP-driven dimerization and DNA stimulated activation~~ of ~~SMC ATPases~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15458651}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xew]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015458651<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
	[[Category: Hopfner, K P.]]		[[Category: Hopfner, K P.]]

OCA: Protected "1xew" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 11:00:38 GMT

Protected "1xew" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:00, 5 January 2013

OCA at 11:00, 5 January 2013

OCA — Sat, 05 Jan 2013 11:00:35 GMT

←Older revision		Revision as of 11:00, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xew.png\|left\|200px]]		[[Image:1xew.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xew", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xew\| PDB=1xew \| SCENE= }}		{{STRUCTURE_1xew\| PDB=1xew \| SCENE= }}

	===Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.===		===Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15458651}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15458651 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15458651}}		{{ABSTRACT_PUBMED_15458651}}

	==About this Structure==		==About this Structure==
-	~~1XEW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA].	+	[[1xew]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15458651~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015458651</ref><references group="xtra"/>
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
	[[Category: Hopfner, K P.]]		[[Category: Hopfner, K P.]]
Line 29:		Line 17:
	[[Category: Schele, A.]]		[[Category: Schele, A.]]
	[[Category: Abc-atpase]]		[[Category: Abc-atpase]]
		+	[[Category: Cell cycle]]
	[[Category: Cohesin]]		[[Category: Cohesin]]
	[[Category: Condensin]]		[[Category: Condensin]]
	[[Category: Smc]]		[[Category: Smc]]
	[[Category: Structural maintenance of chromosome]]		[[Category: Structural maintenance of chromosome]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:39:39 2009''

OCA at 13:39, 16 February 2009

OCA — Mon, 16 Feb 2009 13:39:40 GMT

←Older revision		Revision as of 13:39, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1XEW is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA].	+	1XEW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEW OCA].

	==Reference==		==Reference==
-	~~Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases., Lammens A, Schele A, Hopfner KP, Curr Biol. 2004 Oct 5;14(19):1778-82.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15458651 15458651]~~	+	<ref group="xtra">PMID:15458651</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
	[[Category: Hopfner, K P.]]		[[Category: Hopfner, K P.]]
Line 35:		Line 34:
	[[Category: Structural maintenance of chromosome]]		[[Category: Structural maintenance of chromosome]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 18~~:37:~~02 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:39:39 2009''