1xkm - Revision history

OCA at 09:29, 6 December 2023

OCA — Wed, 06 Dec 2023 09:29:40 GMT

←Older revision		Revision as of 09:29, 6 December 2023
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	==NMR structure of antimicrobial peptide distinctin in water==		==NMR structure of antimicrobial peptide distinctin in water==
-	<StructureSection load='1xkm' size='340' side='right'caption='[[1xkm~~]], [[NMR_Ensembles_of_Models \| 24 NMR models~~]]' scene=''>	+	<StructureSection load='1xkm' size='340' side='right'caption='[[1xkm]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XKM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XKM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [https://pdbe.org/1xkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [https://www.ebi.ac.uk/pdbsum/1xkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xkm ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [https://pdbe.org/1xkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [https://www.ebi.ac.uk/pdbsum/1xkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xkm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amodeo, P]]	+	[[Category: Amodeo P]]
-	[[Category: Andreotti, G]]	+	[[Category: Andreotti G]]
-	[[Category: Motta, A]]	+	[[Category: Motta A]]
-	[[Category: Raimondo, D]]	+	[[Category: Raimondo D]]
-	[[Category: Scaloni, A]]	+	[[Category: Scaloni A]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Disulfide]]~~	+
-	~~[[Category: Four-helix bundle]]~~	+
-	~~[[Category: Heterodimer]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Pore-forming peptide~~]]	+

OCA at 16:39, 27 October 2021

OCA — Wed, 27 Oct 2021 16:39:16 GMT

←Older revision		Revision as of 16:39, 27 October 2021
Line 3:		Line 3:
	<StructureSection load='1xkm' size='340' side='right'caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='1xkm' size='340' side='right'caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XKM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XKM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [~~http~~://pdbe.org/1xkm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xkm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xkm ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [https://pdbe.org/1xkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [https://www.ebi.ac.uk/pdbsum/1xkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xkm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:39, 22 January 2020

OCA — Wed, 22 Jan 2020 17:39:45 GMT

←Older revision		Revision as of 17:39, 22 January 2020
Line 1:		Line 1:

	==NMR structure of antimicrobial peptide distinctin in water==		==NMR structure of antimicrobial peptide distinctin in water==
-	<StructureSection load='1xkm' size='340' side='right' caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>	+	<StructureSection load='1xkm' size='340' side='right'caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Amodeo, P]]		[[Category: Amodeo, P]]
	[[Category: Andreotti, G]]		[[Category: Andreotti, G]]

OCA at 07:21, 18 April 2018

OCA — Wed, 18 Apr 2018 07:21:10 GMT

←Older revision		Revision as of 07:21, 18 April 2018
Line 1:		Line 1:
		+
	==NMR structure of antimicrobial peptide distinctin in water==		==NMR structure of antimicrobial peptide distinctin in water==
	<StructureSection load='1xkm' size='340' side='right' caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='1xkm' size='340' side='right' caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [http://pdbe.org/1xkm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [http://www.ebi.ac.uk/pdbsum/1xkm PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [http://pdbe.org/1xkm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [http://www.ebi.ac.uk/pdbsum/1xkm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xkm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:19, 11 September 2015

OCA — Fri, 11 Sep 2015 09:19:57 GMT

←Older revision		Revision as of 09:19, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [http://www.ebi.ac.uk/pdbsum/1xkm PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [http://pdbe.org/1xkm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [http://www.ebi.ac.uk/pdbsum/1xkm PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xkm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:31, 25 January 2015

OCA — Sun, 25 Jan 2015 10:31:30 GMT

←Older revision		Revision as of 10:31, 25 January 2015
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amodeo, P.]]	+	[[Category: Amodeo, P]]
-	[[Category: Andreotti, G.]]	+	[[Category: Andreotti, G]]
-	[[Category: Motta, A.]]	+	[[Category: Motta, A]]
-	[[Category: Raimondo, D.]]	+	[[Category: Raimondo, D]]
-	[[Category: Scaloni, A.]]	+	[[Category: Scaloni, A]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Disulfide]]		[[Category: Disulfide]]

OCA at 11:51, 29 October 2014

OCA — Wed, 29 Oct 2014 11:51:32 GMT

←Older revision		Revision as of 11:51, 29 October 2014
Line 1:		Line 1:
-	[[~~Image~~:1xkm.~~png\|left\|200px~~]]	+	==NMR structure of antimicrobial peptide distinctin in water==
		+	<StructureSection load='1xkm' size='340' side='right' caption='[[1xkm]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKM FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xkm RCSB], [http://www.ebi.ac.uk/pdbsum/1xkm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many bioactive peptides, presenting an unstructured conformation in aqueous solution, are made resistant to degradation by posttranslational modifications. Here, we describe how molecular oligomerization in aqueous solution can generate a still unknown transport form for amphipathic peptides, which is more compact and resistant to proteases than forms related to any possible monomer. This phenomenon emerged from 3D structure, function, and degradation properties of distinctin, a heterodimeric antimicrobial compound consisting of two peptide chains linked by a disulfide bond. After homodimerization in water, this peptide exhibited a fold consisting of a symmetrical full-parallel four-helix bundle, with a well secluded hydrophobic core and exposed basic residues. This fold significantly stabilizes distinctin against proteases compared with other linear amphipathic peptides, without affecting its antimicrobial, hemolytic, and ion-channel formation properties after membrane interaction. This full-parallel helical orientation represents a perfect compromise between formation of a stable structure in water and requirement of a drastic structural rearrangement in membranes to elicit antimicrobial potential. Thus, distinctin can be claimed as a prototype of a previously unrecognized class of antimicrobial derivatives. These results suggest a critical revision of the role of peptide oligomerization whenever solubility or resistance to proteases is known to affect biological properties.

-	~~{{STRUCTURE_1xkm\| PDB=1xkm \| SCENE= }}~~	+	A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin.,Raimondo D, Andreotti G, Saint N, Amodeo P, Renzone G, Sanseverino M, Zocchi I, Molle G, Motta A, Scaloni A Proc Natl Acad Sci U S A. 2005 May 3;102(18):6309-14. Epub 2005 Apr 19. PMID:15840728<ref>PMID:15840728</ref>

-	~~===NMR structure~~ of ~~antimicrobial peptide distinctin in water===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15840728}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xkm]] is a 4 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1XKM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015840728<~~/~~ref~~><~~ref group="xtra">PMID:011297740</ref><references group="xtra"~~/>	+
	[[Category: Amodeo, P.]]		[[Category: Amodeo, P.]]
	[[Category: Andreotti, G.]]		[[Category: Andreotti, G.]]

OCA at 12:14, 23 January 2013

OCA — Wed, 23 Jan 2013 12:14:34 GMT

←Older revision		Revision as of 12:14, 23 January 2013
Line 1:		Line 1:
	[[Image:1xkm.png\|left\|200px]]		[[Image:1xkm.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xkm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xkm\| PDB=1xkm \| SCENE= }}		{{STRUCTURE_1xkm\| PDB=1xkm \| SCENE= }}

	===NMR structure of antimicrobial peptide distinctin in water===		===NMR structure of antimicrobial peptide distinctin in water===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15840728}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15840728 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15840728}}		{{ABSTRACT_PUBMED_15840728}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15840728~~</ref><ref group="xtra">PMID:~~11297740~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015840728</ref><ref group="xtra">PMID:011297740</ref><references group="xtra"/>
	[[Category: Amodeo, P.]]		[[Category: Amodeo, P.]]
	[[Category: Andreotti, G.]]		[[Category: Andreotti, G.]]
Line 33:		Line 22:
	[[Category: Heterodimer]]		[[Category: Heterodimer]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
-	[[Category: Nmr structure]]
	[[Category: Pore-forming peptide]]		[[Category: Pore-forming peptide]]

OCA: Protected "1xkm" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 22:18:37 GMT

Protected "1xkm" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:18, 14 March 2011

OCA at 22:18, 14 March 2011

OCA — Mon, 14 Mar 2011 22:18:35 GMT

←Older revision		Revision as of 22:18, 14 March 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xkm.png\|left\|200px]]		[[Image:1xkm.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA].	+	[[1xkm]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKM OCA].

	==Reference==		==Reference==
-	A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin., Raimondo D, Andreotti G, Saint N, Amodeo P, Renzone G, Sanseverino M, Zocchi I, Molle G, Motta A, Scaloni A, Proc Natl Acad Sci U S A. 2005 May 3;102(18):6309-14. Epub 2005 Apr 19. PMID:~~[http:~~/~~/www.ncbi.nlm.nih.gov/pubmed/15840728 15840728]~~	+	<ref group="xtra">PMID:15840728</ref><ref group="xtra">PMID:11297740</ref><references group="xtra"/>
-		+
-	A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta., Batista CV, Scaloni A, Rigden DJ, Silva LR, Rodrigues Romero A, Dukor R, Sebben A, Talamo F, Bloch C, FEBS Lett. 2001 Apr 6;494(1-2):85-9. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11297740 11297740]~~	+
	[[Category: Amodeo, P.]]		[[Category: Amodeo, P.]]
	[[Category: Andreotti, G.]]		[[Category: Andreotti, G.]]
Line 31:		Line 28:
	[[Category: Raimondo, D.]]		[[Category: Raimondo, D.]]
	[[Category: Scaloni, A.]]		[[Category: Scaloni, A.]]
		+	[[Category: Antibiotic]]
	[[Category: Disulfide]]		[[Category: Disulfide]]
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
Line 37:		Line 35:
	[[Category: Nmr structure]]		[[Category: Nmr structure]]
	[[Category: Pore-forming peptide]]		[[Category: Pore-forming peptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:38:22 2008''