1xqj - Revision history

OCA at 06:48, 23 August 2023

OCA — Wed, 23 Aug 2023 06:48:44 GMT

←Older revision		Revision as of 06:48, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1xqg\|1xqg]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SERPINB5, PI5 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [https://pdbe.org/1xqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [https://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [https://pdbe.org/1xqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [https://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN]] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.	+	[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Al-Ayyoubi, M]]	+	[[Category: Al-Ayyoubi M]]
-	[[Category: Gettins~~, P G~~]]	+	[[Category: Gettins PG]]
-	[[Category: Volz, K]]	+	[[Category: Volz K]]
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Maspin]]~~	+
-	~~[[Category: Serpin]]~~	+
-	~~[[Category: Tumor suppression~~]]	+

OCA at 16:43, 20 October 2021

OCA — Wed, 20 Oct 2021 16:43:42 GMT

←Older revision		Revision as of 16:43, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xqg\|1xqg]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xqg\|1xqg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [~~http~~://pdbe.org/1xqj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [https://pdbe.org/1xqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [https://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN]] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.	+	[[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN]] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:14, 6 January 2021

OCA — Wed, 06 Jan 2021 10:14:44 GMT

←Older revision		Revision as of 10:14, 6 January 2021
Line 1:		Line 1:

	==3.10 A Crystal structure of maspin, space group I 4 2 2==		==3.10 A Crystal structure of maspin, space group I 4 2 2==
-	<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xqg\|1xqg]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Serpin\|Serpin]]	+	*[[Serpin 3D structures\|Serpin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Al-Ayyoubi, M]]		[[Category: Al-Ayyoubi, M]]
	[[Category: Gettins, P G]]		[[Category: Gettins, P G]]

OCA at 06:57, 9 January 2019

OCA — Wed, 09 Jan 2019 06:57:43 GMT

←Older revision		Revision as of 06:57, 9 January 2019
Line 3:		Line 3:
	<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xq/1xqj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xq/1xqj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Al-Ayyoubi, M]]		[[Category: Al-Ayyoubi, M]]
	[[Category: Gettins, P G]]		[[Category: Gettins, P G]]

OCA at 06:36, 5 April 2017

OCA — Wed, 05 Apr 2017 06:36:27 GMT

←Older revision		Revision as of 06:36, 5 April 2017
Line 1:		Line 1:
		+
	==3.10 A Crystal structure of maspin, space group I 4 2 2==		==3.10 A Crystal structure of maspin, space group I 4 2 2==
	<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Al-Ayyoubi, M]]		[[Category: Al-Ayyoubi, M]]
	[[Category: Gettins, P G]]		[[Category: Gettins, P G]]

OCA at 14:20, 9 February 2016

OCA — Tue, 09 Feb 2016 14:20:59 GMT

←Older revision		Revision as of 14:20, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xqj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:05, 10 September 2015

OCA — Thu, 10 Sep 2015 23:05:07 GMT

←Older revision		Revision as of 23:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://pdbe.org/1xqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN]] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xqj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Al-Ayyoubi, M]]		[[Category: Al-Ayyoubi, M]]
	[[Category: Gettins, P G]]		[[Category: Gettins, P G]]

OCA at 09:55, 8 January 2015

OCA — Thu, 08 Jan 2015 09:55:58 GMT

←Older revision		Revision as of 09:55, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Al-Ayyoubi, M.]]	+	[[Category: Al-Ayyoubi, M]]
-	[[Category: Gettins, P G.]]	+	[[Category: Gettins, P G]]
-	[[Category: Volz, K.]]	+	[[Category: Volz, K]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]
	[[Category: Maspin]]		[[Category: Maspin]]
	[[Category: Serpin]]		[[Category: Serpin]]
	[[Category: Tumor suppression]]		[[Category: Tumor suppression]]

OCA at 20:03, 28 September 2014

OCA — Sun, 28 Sep 2014 20:03:54 GMT

←Older revision		Revision as of 20:03, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xqj.~~png~~\|~~left~~\|200px]]	+	==3.10 A Crystal structure of maspin, space group I 4 2 2==
		+	<StructureSection load='1xqj' size='340' side='right' caption='[[1xqj]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xqg\|1xqg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5, PI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [http://www.ebi.ac.uk/pdbsum/1xqj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xq/1xqj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.

-	~~{{STRUCTURE_1xqj\| PDB=1xqj \| SCENE= }}~~	+	Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained.,Al-Ayyoubi M, Gettins PG, Volz K J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821<ref>PMID:15501821</ref>

-	~~===3.10 A Crystal structure of maspin~~, ~~space group I 4 2 2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15501821}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1xqj]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA].~~	+

	==See Also==		==See Also==
	*[[Serpin\|Serpin]]		*[[Serpin\|Serpin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015501821<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Al-Ayyoubi, M.]]		[[Category: Al-Ayyoubi, M.]]

OCA: Protected "1xqj" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 14:08:03 GMT

Protected "1xqj" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:08, 20 October 2012