1xsc - Revision history

OCA at 07:57, 15 May 2024

OCA — Wed, 15 May 2024 07:57:43 GMT

←Older revision		Revision as of 07:57, 15 May 2024
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	==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==		==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==
-	<StructureSection load='1xsc' size='340' side='right'caption='[[1xsc~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>	+	<StructureSection load='1xsc' size='340' side='right'caption='[[1xsc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1xsa\|1xsa]], [[1xsb\|1xsb]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Bis(~~5'-~~nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5~~'~~-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [https://pdbe.org/1xsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [https://www.ebi.ac.uk/pdbsum/1xsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [https://pdbe.org/1xsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [https://www.ebi.ac.uk/pdbsum/1xsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AP4A_HUMAN AP4A_HUMAN]] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.	+	[https://www.uniprot.org/uniprot/AP4A_HUMAN AP4A_HUMAN] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Buyya, S]]	+	[[Category: Buyya S]]
-	[[Category: Gayler~~, K R~~]]	+	[[Category: Gayler KR]]
-	[[Category: Gooley~~, P R~~]]	+	[[Category: Gooley PR]]
-	[[Category: Gunawardana, D]]	+	[[Category: Gunawardana D]]
-	[[Category: McLennan~~, A G~~]]	+	[[Category: McLennan AG]]
-	[[Category: Swarbrick~~, J D]]~~	+	[[Category: Swarbrick JD]]
-	~~[[Category: Alpha-beta]]~~	+
-	~~[[Category: Human ap4a atp hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nudix enzyme~~]]	+

OCA at 16:18, 3 November 2021

OCA — Wed, 03 Nov 2021 16:18:46 GMT

←Older revision		Revision as of 16:18, 3 November 2021
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	<StructureSection load='1xsc' size='340' side='right'caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1xsc' size='340' side='right'caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XSC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xsa\|1xsa]], [[1xsb\|1xsb]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [~~http~~://pdbe.org/1xsc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xsc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [https://pdbe.org/1xsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [https://www.ebi.ac.uk/pdbsum/1xsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AP4A_HUMAN AP4A_HUMAN]] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.	+	[[https://www.uniprot.org/uniprot/AP4A_HUMAN AP4A_HUMAN]] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:47, 22 January 2020

OCA — Wed, 22 Jan 2020 17:47:49 GMT

←Older revision		Revision as of 17:47, 22 January 2020
Line 1:		Line 1:

	==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==		==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==
-	<StructureSection load='1xsc' size='340' side='right' caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>	+	<StructureSection load='1xsc' size='340' side='right'caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Buyya, S]]		[[Category: Buyya, S]]
	[[Category: Gayler, K R]]		[[Category: Gayler, K R]]

OCA at 07:26, 18 April 2018

OCA — Wed, 18 Apr 2018 07:26:54 GMT

←Older revision		Revision as of 07:26, 18 April 2018
Line 1:		Line 1:
		+
	==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==		==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==
	<StructureSection load='1xsc' size='340' side='right' caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1xsc' size='340' side='right' caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://pdbe.org/1xsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://pdbe.org/1xsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:21, 7 February 2016

OCA — Sun, 07 Feb 2016 05:21:34 GMT

←Older revision		Revision as of 05:21, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xsc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:15, 9 September 2015

OCA — Wed, 09 Sep 2015 22:15:01 GMT

←Older revision		Revision as of 22:15, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1xsc' size='340' side='right' caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1xsc' size='340' side='right' caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://pdbe.org/1xsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xsc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Buyya, S]]		[[Category: Buyya, S]]
	[[Category: Gayler, K R]]		[[Category: Gayler, K R]]

OCA at 08:09, 24 December 2014

OCA — Wed, 24 Dec 2014 08:09:32 GMT

←Older revision		Revision as of 08:09, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AP4A_HUMAN AP4A_HUMAN]] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Buyya, S.]]	+	[[Category: Buyya, S]]
-	[[Category: Gayler, K R.]]	+	[[Category: Gayler, K R]]
-	[[Category: Gooley, P R.]]	+	[[Category: Gooley, P R]]
-	[[Category: Gunawardana, D.]]	+	[[Category: Gunawardana, D]]
-	[[Category: McLennan, A G.]]	+	[[Category: McLennan, A G]]
-	[[Category: Swarbrick, J D.]]	+	[[Category: Swarbrick, J D]]
	[[Category: Alpha-beta]]		[[Category: Alpha-beta]]
	[[Category: Human ap4a atp hydrolase]]		[[Category: Human ap4a atp hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nudix enzyme]]		[[Category: Nudix enzyme]]

OCA at 19:10, 29 September 2014

OCA — Mon, 29 Sep 2014 19:10:57 GMT

←Older revision		Revision as of 19:10, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xsc.~~png~~\|~~left~~\|200px]]	+	==Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP==
		+	<StructureSection load='1xsc' size='340' side='right' caption='[[1xsc]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XSC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xsa\|1xsa]], [[1xsb\|1xsb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xsc RCSB], [http://www.ebi.ac.uk/pdbsum/1xsc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Asymmetric diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) hydrolases play a major role in maintaining homeostasis by cleaving the metabolite diadenosine tetraphosphate (Ap(4)A) back into ATP and AMP. The NMR solution structures of the 17-kDa human asymmetric Ap(4)A hydrolase have been solved in both the presence and absence of the product ATP. The adenine moiety of the nucleotide predominantly binds in a ring stacking arrangement equivalent to that observed in the x-ray structure of the homologue from Caenorhabditis elegans. The binding site is, however, markedly divergent to that observed in the plant/pathogenic bacteria class of enzymes, opening avenues for the exploration of specific therapeutics. Binding of ATP induces substantial conformational and dynamic changes that were not observed in the C. elegans structure. In contrast to the C. elegans homologue, important side chains that play a major role in substrate binding do not have to reorient to accommodate the ligand. This may have important implications in the mechanism of substrate recognition in this class of enzymes.

-	~~{{STRUCTURE_1xsc\| PDB=1xsc \| SCENE= }}~~	+	Structure and substrate-binding mechanism of human Ap4A hydrolase.,Swarbrick JD, Buyya S, Gunawardana D, Gayler KR, McLennan AG, Gooley PR J Biol Chem. 2005 Mar 4;280(9):8471-81. Epub 2004 Dec 13. PMID:15596429<ref>PMID:15596429</ref>

-	~~===Structure~~ of the ~~nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15596429}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1xsc]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015596429<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Buyya, S.]]		[[Category: Buyya, S.]]

OCA: Protected "1xsc" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 12:05:28 GMT

Protected "1xsc" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:05, 5 January 2013

OCA at 12:05, 5 January 2013

OCA — Sat, 05 Jan 2013 12:05:25 GMT

←Older revision		Revision as of 12:05, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xsc.png\|left\|200px]]		[[Image:1xsc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xsc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xsc\| PDB=1xsc \| SCENE= }}		{{STRUCTURE_1xsc\| PDB=1xsc \| SCENE= }}

	===Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP===		===Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15596429}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15596429 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15596429}}		{{ABSTRACT_PUBMED_15596429}}

	==About this Structure==		==About this Structure==
-	~~1XSC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA].	+	[[1xsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15596429~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015596429</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Buyya, S.]]		[[Category: Buyya, S.]]
Line 33:		Line 21:
	[[Category: Alpha-beta]]		[[Category: Alpha-beta]]
	[[Category: Human ap4a atp hydrolase]]		[[Category: Human ap4a atp hydrolase]]
-	[[Category: ~~Nmr~~]]	+	[[Category: Hydrolase]]
	[[Category: Nudix enzyme]]		[[Category: Nudix enzyme]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:35:56 2009''