1xu8 - Revision history

OCA at 08:09, 25 October 2023

OCA — Wed, 25 Oct 2023 08:09:10 GMT

←Older revision		Revision as of 08:09, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1xu8' size='340' side='right'caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1xu8' size='340' side='right'caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [~~http~~://pdbe.org/1xu8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xu8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xu8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [https://pdbe.org/1xu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [https://www.ebi.ac.uk/pdbsum/1xu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xu8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN]] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.	+	[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bashtannyk-Puhalovich~~, T A~~]]	+	[[Category: Bashtannyk-Puhalovich TA]]
-	[[Category: Irving~~, J A~~]]	+	[[Category: Irving JA]]
-	[[Category: Kim, N]]	+	[[Category: Kim N]]
-	[[Category: Law~~, R H~~]]	+	[[Category: Law RH]]
-	[[Category: Rossjohn, J]]	+	[[Category: Rossjohn J]]
-	[[Category: Ruzyla, K]]	+	[[Category: Ruzyla K]]
-	[[Category: Whisstock~~, J C~~]]	+	[[Category: Whisstock JC]]
-	[[Category: Worrall~~, D M]]~~	+	[[Category: Worrall DM]]
-	~~[[Category: Maspin]]~~	+
-	~~[[Category: Serpin]]~~	+
-	~~[[Category: Serpinb5]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Tumor suppressor~~]]	+

OCA at 10:21, 6 January 2021

OCA — Wed, 06 Jan 2021 10:21:10 GMT

←Older revision		Revision as of 10:21, 6 January 2021
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	==The 2.8 A structure of a tumour suppressing serpin==		==The 2.8 A structure of a tumour suppressing serpin==
-	<StructureSection load='1xu8' size='340' side='right' caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1xu8' size='340' side='right'caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://pdbe.org/1xu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xu8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://pdbe.org/1xu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xu8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Serpin\|Serpin]]	+	*[[Serpin 3D structures\|Serpin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bashtannyk-Puhalovich, T A]]		[[Category: Bashtannyk-Puhalovich, T A]]
	[[Category: Irving, J A]]		[[Category: Irving, J A]]

OCA at 07:26, 18 April 2018

OCA — Wed, 18 Apr 2018 07:26:55 GMT

←Older revision		Revision as of 07:26, 18 April 2018
Line 1:		Line 1:
		+
	==The 2.8 A structure of a tumour suppressing serpin==		==The 2.8 A structure of a tumour suppressing serpin==
	<StructureSection load='1xu8' size='340' side='right' caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1xu8' size='340' side='right' caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://pdbe.org/1xu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://pdbe.org/1xu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xu8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xu8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xu8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:16, 10 February 2016

OCA — Wed, 10 Feb 2016 00:16:21 GMT

←Older revision		Revision as of 00:16, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xu8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:27, 11 September 2015

OCA — Fri, 11 Sep 2015 03:27:56 GMT

←Older revision		Revision as of 03:27, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1xu8' size='340' side='right' caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1xu8' size='340' side='right' caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://pdbe.org/1xu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN]] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1xu8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bashtannyk-Puhalovich, T A]]		[[Category: Bashtannyk-Puhalovich, T A]]
	[[Category: Irving, J A]]		[[Category: Irving, J A]]

OCA at 09:35, 8 January 2015

OCA — Thu, 08 Jan 2015 09:35:30 GMT

←Older revision		Revision as of 09:35, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bashtannyk-Puhalovich, T A.]]	+	[[Category: Bashtannyk-Puhalovich, T A]]
-	[[Category: Irving, J A.]]	+	[[Category: Irving, J A]]
-	[[Category: Kim, N.]]	+	[[Category: Kim, N]]
-	[[Category: Law, R H.]]	+	[[Category: Law, R H]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
-	[[Category: Ruzyla, K.]]	+	[[Category: Ruzyla, K]]
-	[[Category: Whisstock, J C.]]	+	[[Category: Whisstock, J C]]
-	[[Category: Worrall, D M.]]	+	[[Category: Worrall, D M]]
	[[Category: Maspin]]		[[Category: Maspin]]
	[[Category: Serpin]]		[[Category: Serpin]]

OCA at 23:30, 28 September 2014

OCA — Sun, 28 Sep 2014 23:30:30 GMT

←Older revision		Revision as of 23:30, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1xu8.~~png~~\|~~left~~\|200px]]	+	==The 2.8 A structure of a tumour suppressing serpin==
		+	<StructureSection load='1xu8' size='340' side='right' caption='[[1xu8]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XU8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SERPINB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xu8 RCSB], [http://www.ebi.ac.uk/pdbsum/1xu8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xu8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Maspin is a serpin that acts as a tumor suppressor in a range of human cancers, including tumors of the breast and lung. Maspin is crucial for development, because homozygous loss of the gene is lethal; however, the precise physiological role of the molecule is unclear. To gain insight into the function of human maspin, we have determined its crystal structure in two similar, but non-isomorphous crystal forms, to 2.1- and 2.8-A resolution, respectively. The structure reveals that maspin adopts the native serpin fold in which the reactive center loop is expelled fully from the A beta-sheet, makes minimal contacts with the core of the molecule, and exhibits a high degree of flexibility. A buried salt bridge unique to maspin orthologues causes an unusual bulge in the region around the D and E alpha-helices, an area of the molecule demonstrated in other serpins to be important for cofactor recognition. Strikingly, the structural data reveal that maspin is able to undergo conformational change in and around the G alpha-helix, switching between an open and a closed form. This change dictates the electrostatic character of a putative cofactor binding surface and highlights this region as a likely determinant of maspin function. The high resolution crystal structure of maspin provides a detailed molecular framework to elucidate the mechanism of function of this important tumor suppressor.

-	~~{{STRUCTURE_1xu8\| PDB=1xu8 \| SCENE= }}~~	+	The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.,Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC J Biol Chem. 2005 Jun 10;280(23):22356-64. Epub 2005 Mar 10. PMID:15760906<ref>PMID:15760906</ref>

-	~~===The 2.8 A structure~~ of ~~a tumour suppressing serpin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15760906}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1xu8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA].~~	+

	==See Also==		==See Also==
	*[[Serpin\|Serpin]]		*[[Serpin\|Serpin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015760906<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bashtannyk-Puhalovich, T A.]]		[[Category: Bashtannyk-Puhalovich, T A.]]

OCA: Protected "1xu8" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 15:38:37 GMT

Protected "1xu8" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:38, 20 October 2012

OCA at 15:38, 20 October 2012

OCA — Sat, 20 Oct 2012 15:38:35 GMT

←Older revision		Revision as of 15:38, 20 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1xu8.png\|left\|200px]]		[[Image:1xu8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1xu8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1xu8\| PDB=1xu8 \| SCENE= }}		{{STRUCTURE_1xu8\| PDB=1xu8 \| SCENE= }}

	===The 2.8 A structure of a tumour suppressing serpin===		===The 2.8 A structure of a tumour suppressing serpin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15760906}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15760906 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15760906}}		{{ABSTRACT_PUBMED_15760906}}

	==About this Structure==		==About this Structure==
-	~~1XU8~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA].	+	[[1xu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA].
		+
		+	==See Also==
		+	*[[Serpin\|Serpin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15760906~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015760906</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bashtannyk-Puhalovich, T A.]]		[[Category: Bashtannyk-Puhalovich, T A.]]
Line 36:		Line 27:
	[[Category: Serpin]]		[[Category: Serpin]]
	[[Category: Serpinb5]]		[[Category: Serpinb5]]
		+	[[Category: Signaling protein]]
	[[Category: Tumor suppressor]]		[[Category: Tumor suppressor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:53:12 2009''

OCA at 11:53, 17 February 2009

OCA — Tue, 17 Feb 2009 11:53:16 GMT

←Older revision		Revision as of 11:53, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1XU8 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA].	+	1XU8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU8 OCA].

	==Reference==		==Reference==
-	The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix., Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC, J Biol Chem. 2005 Jun 10;280(23):22356-64. Epub 2005 Mar 10. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15760906 15760906]~~	+	<ref group="xtra">PMID:15760906</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Bashtannyk-Puhalovich, T A.]]		[[Category: Bashtannyk-Puhalovich, T A.]]
	[[Category: Irving, J A.]]		[[Category: Irving, J A.]]
Line 39:		Line 38:
	[[Category: Tumor suppressor]]		[[Category: Tumor suppressor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 19~~:10:~~25 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:53:12 2009''